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M. Mason, H. Resnik, A. Minot, J. Rainey, C. Pilcher, T. Harrison (1937)
MECHANISM OF EXPERIMENTAL UREMIAJAMA Internal Medicine, 60
P. Roen (1944)
The Chemical Basis of Uremia: Blood PhenolThe Journal of Urology, 51
M. F. Mason , H. Resnik, A. S. Minot, J. Rainey, C. Pilcher (1937)
Mechanism of Experimental UremiaArch. Int. Med., 60
S. Barker (1944)
THE DIRECT COLORIMETRIC DETERMINATION OF UREA IN BLOOD AND URINEJournal of Biological Chemistry, 152
A. Fishberg (1934)
Hypertension and nephritisThe American Journal of the Medical Sciences, 188
W. Raab (1944)
Cardiotoxic Substances in the Blood and Heart Muscle in UremiaJ. Lab. & Clin. Med., 29
Abstract FISHBERG1 has defined uremia as "A complex auto-intoxication, the variegated clinical picture being the summation of the effects of retention of various urinary constituents." He showed that virtually every known urinary constituent has at one time or another been indicted as an etiologic factor in the production of this syndrome. Of the various retained excretory products, certain ones seem to play a primary role while others are entirely of secondary importance. Some of the manifestations of the uremic syndrome are as yet unexplained, among them various types of cutaneous lesions, pericarditis and others. However, through extensive investigations in recent years, an approach to the more important manifestations has been gained. Raab2 has postulated that the presence of catechol and phenol compounds is a highly contributory if not the main cause of the electrocardiographic changes and the physical signs of cardiac failure in uremic patients. The gastrointestinal symptoms have References 1. Fishberg, A. M.: Hypertension and Nephritis , ed. 4, Philadelphia, Lea & Febiger, 1940. 2. Raab, W.: Cardiotoxic Substances in the Blood and Heart Muscle in Uremia , J. Lab. & Clin. Med. 29:715-734 ( (July) ) 1944. 3. Mason, M. F.; Resnik, H.; Minot, A. S.; Rainey, J.; Pilcher, C., and Harrison, T. R.: Mechanism of Experimental Uremia , Arch. Int. Med. 60: 312-336 ( (Aug.) ) 1937. 4. Roen, P. R.: The Chemical Basis of Uremia: Blood Phenol , J. Urol. 51:110-116 ( (Jan.) ) 1944. 5. Barker, S. B.: The Direct Colorimetric Determination of Urea in Blood and Urine , J. Biol. Chem. 152:453-463 ( (Feb.) ) 1944.
Archives of Surgery – American Medical Association
Published: Oct 1, 1946
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