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EFFECT OF PENICILLIN IN EXPERIMENTAL INTESTINAL OBSTRUCTION: Cure of Strangulated Ileal Obstructions Treated with Penicillin Prior to Late Resection

EFFECT OF PENICILLIN IN EXPERIMENTAL INTESTINAL OBSTRUCTION: Cure of Strangulated Ileal... Abstract EXPERIMENTAL evidence for the importance of the role played by bacteria in producing "toxemia" and death in intestinal obstruction is briefly as follows: Dogs having isolated obstructed jejunal loops will die from a rather characteristic train of symptoms within a few days, usually four or five.1 When penicillin is either placed in such loops or administered parenterally to dogs in which such loops have been constructed, these dogs will be protected from "toxemia" and death for a significant period, sometimes for over a month.2 Succinylsulfathiazole, which is absorbed more slowly from isolated loops, will also protect animals with isolated obstructed loops when placed in the loops at the time of operation.3 One such dog was allowed to survive for over a year.3b Prior to the advent of potent antibacterial drugs for experiments of this type, the importance of bacteria as the cause of death was strongly References 1. Stone, H. B.; Bernheim, B. M., and Whipple, G. H.: Intestinal Obstruction: A Study of the Toxic Factors , Bull. Johns Hopkins Hosp. 23:159-165 ( (June) ) 1912. 2. Harper, W. H., and Blain, A., III: The Effect of Penicillin in Experimental Intestinal Obstruction: Preliminary Report on Closed Loop Studies , Bull. Johns Hopkins Hosp. 76:221-244 ( (June) ) 1945. 3. (a) Poth, E. J., and Firor, W. M.: Unpublished data. 4. (b) Harper, W. H., and Blain, A., III: Unpublished data. 5. Davis, D. M., and Stone, H. B.: Studies on the Toxicity in Intestinal Secretion , J. Exper. Med. 26:687-691 ( (Nov.) ) 1917.Crossref 6. Murphy, F. T., and Brooks, B.: Intestinal Obstruction: An Experimental Study of the Causes of Symptoms and Death , Arch. Int. Med. 15:392-412 ( (March) ) 1915.Crossref 7. Dragstedt, L. R.; Moorehead, J. J., and Burcky, F. W.: Intestinal Obstruction: An Experimental Study of the Intoxication in Closed Intestinal Loops , J. Exper. Med. 25:421-439 ( (March) ) 1917.Crossref 8. Sarnoff, S. J., and Poth, E. J.: Intestinal Obstruction: I. The Protective Action of Succinylsulfathiazole Following Simple Venous Occlusion , Surgery 16:927-931 ( (Dec.) ) 1944. 9. Sarnoff, S. J., and Fine, J.: The Effect of Chemotherapy on the Ileum Subjected to Vascular Injury , Ann. Surg. 121:74-82 ( (Jan.) ) 1945.Crossref 10. Blain, A., III, and Kennedy, J. D.: The Effect of Penicillin in Experimental Intestinal Obstruction: Studies on Strangulated Low Ileal Obstructions , Bull. Johns Hopkins Hosp. 79:1-20 ( (July) ) 1946. 11. Miller, C. J.: Study of Three Hundred and Forty-Three Surgical Cases of Intestinal Obstruction , Ann. Surg. 89:91-107 ( (Jan.) ) 1929.Crossref 12. Calihan, R. J.; Kennedy, J. D., and Blain, A., III: Intestinal Obstruction: A Study of Two Hundred and Four Acute Cases with Reference to the Possible Efficacy of Anti-Bacterial Therapy , Bull. Johns Hopkins Hosp. 79:21-33 ( (July) ) 1946. 13. Moses, W. R.: Acute Obstruction of the Small Intestine: A Report of One Hundred and Eighteen Cases , New England J. Med. 234:78-81 ( (Jan. 17) ) 1946.Crossref 14. Abbott, W. O., and Johnston, C. J.: Intubation Studies of the Human Small Intestine , Surg., Gynec. & Obst. 66:691-697 ( (April) ) 1938. 15. Johnston, C. G.: Decompression in the Treatment of Intestinal Obstruction , Surg., Gynec. & Obst. 70:365-367 ( (Feb.) ) 1940. 16. Wangensteen, O. H.: Intestinal Obstructions . ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1942. 17. Hartwell, J. A., and Hoguet, J. P.: Experimental Intestinal Obstruction in Dogs with Especial Reference to the Cause of Death and the Treatment by Large Amounts of Normal Saline Solution , J. A. M. A. 59:82-87 ( (July 13) ) 1912. 18. McLean, A., and Andries, R. C.: Ileus Considered Experimentally , J. A. M. A. 59:1614-1617 ( (Nov. 2) ) 1912. 19. Haden, R. L., and Orr, T. G.: Effect of Sodium Chloride on the Chemical Changes in the Blood of the Dog After Pyloric and Intestinal Obstruction , J. Exper. Med. 38:55-71 ( (July) ) 1923. 20. MacCallum, W. G.; Lintz, J.; Vermilye, H. N.; Leggett, T. H., and Boas, E.: The Effect of Pyloric Obstruction in Relation to Gastric Tetany , Bull. Johns Hopkins Hosp. 31:1-7 ( (Jan.) ) 1920. 21. Coller, F. A.; Bartlett, R. M.; Bingham, D. L. C.; Maddock, W. G., and Pedersen, S.: Replacement of Sodium Chloride in Surgical Patients , Ann. Surg. 108:769-782 ( (Oct.) ) 1938. 22. McKittrick, L. S., and Sarris, S. P.: Acute Mechanical Obstruction of the Small Bowel: Its Diagnosis and Treatment , New England J. Med. 222:611-622 ( (April 11) ) 1940. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

EFFECT OF PENICILLIN IN EXPERIMENTAL INTESTINAL OBSTRUCTION: Cure of Strangulated Ileal Obstructions Treated with Penicillin Prior to Late Resection

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1946.01230060386002
Publisher site
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Abstract

Abstract EXPERIMENTAL evidence for the importance of the role played by bacteria in producing "toxemia" and death in intestinal obstruction is briefly as follows: Dogs having isolated obstructed jejunal loops will die from a rather characteristic train of symptoms within a few days, usually four or five.1 When penicillin is either placed in such loops or administered parenterally to dogs in which such loops have been constructed, these dogs will be protected from "toxemia" and death for a significant period, sometimes for over a month.2 Succinylsulfathiazole, which is absorbed more slowly from isolated loops, will also protect animals with isolated obstructed loops when placed in the loops at the time of operation.3 One such dog was allowed to survive for over a year.3b Prior to the advent of potent antibacterial drugs for experiments of this type, the importance of bacteria as the cause of death was strongly References 1. Stone, H. B.; Bernheim, B. M., and Whipple, G. H.: Intestinal Obstruction: A Study of the Toxic Factors , Bull. Johns Hopkins Hosp. 23:159-165 ( (June) ) 1912. 2. Harper, W. H., and Blain, A., III: The Effect of Penicillin in Experimental Intestinal Obstruction: Preliminary Report on Closed Loop Studies , Bull. Johns Hopkins Hosp. 76:221-244 ( (June) ) 1945. 3. (a) Poth, E. J., and Firor, W. M.: Unpublished data. 4. (b) Harper, W. H., and Blain, A., III: Unpublished data. 5. Davis, D. M., and Stone, H. B.: Studies on the Toxicity in Intestinal Secretion , J. Exper. Med. 26:687-691 ( (Nov.) ) 1917.Crossref 6. Murphy, F. T., and Brooks, B.: Intestinal Obstruction: An Experimental Study of the Causes of Symptoms and Death , Arch. Int. Med. 15:392-412 ( (March) ) 1915.Crossref 7. Dragstedt, L. R.; Moorehead, J. J., and Burcky, F. W.: Intestinal Obstruction: An Experimental Study of the Intoxication in Closed Intestinal Loops , J. Exper. Med. 25:421-439 ( (March) ) 1917.Crossref 8. Sarnoff, S. J., and Poth, E. J.: Intestinal Obstruction: I. The Protective Action of Succinylsulfathiazole Following Simple Venous Occlusion , Surgery 16:927-931 ( (Dec.) ) 1944. 9. Sarnoff, S. J., and Fine, J.: The Effect of Chemotherapy on the Ileum Subjected to Vascular Injury , Ann. Surg. 121:74-82 ( (Jan.) ) 1945.Crossref 10. Blain, A., III, and Kennedy, J. D.: The Effect of Penicillin in Experimental Intestinal Obstruction: Studies on Strangulated Low Ileal Obstructions , Bull. Johns Hopkins Hosp. 79:1-20 ( (July) ) 1946. 11. Miller, C. J.: Study of Three Hundred and Forty-Three Surgical Cases of Intestinal Obstruction , Ann. Surg. 89:91-107 ( (Jan.) ) 1929.Crossref 12. Calihan, R. J.; Kennedy, J. D., and Blain, A., III: Intestinal Obstruction: A Study of Two Hundred and Four Acute Cases with Reference to the Possible Efficacy of Anti-Bacterial Therapy , Bull. Johns Hopkins Hosp. 79:21-33 ( (July) ) 1946. 13. Moses, W. R.: Acute Obstruction of the Small Intestine: A Report of One Hundred and Eighteen Cases , New England J. Med. 234:78-81 ( (Jan. 17) ) 1946.Crossref 14. Abbott, W. O., and Johnston, C. J.: Intubation Studies of the Human Small Intestine , Surg., Gynec. & Obst. 66:691-697 ( (April) ) 1938. 15. Johnston, C. G.: Decompression in the Treatment of Intestinal Obstruction , Surg., Gynec. & Obst. 70:365-367 ( (Feb.) ) 1940. 16. Wangensteen, O. H.: Intestinal Obstructions . ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1942. 17. Hartwell, J. A., and Hoguet, J. P.: Experimental Intestinal Obstruction in Dogs with Especial Reference to the Cause of Death and the Treatment by Large Amounts of Normal Saline Solution , J. A. M. A. 59:82-87 ( (July 13) ) 1912. 18. McLean, A., and Andries, R. C.: Ileus Considered Experimentally , J. A. M. A. 59:1614-1617 ( (Nov. 2) ) 1912. 19. Haden, R. L., and Orr, T. G.: Effect of Sodium Chloride on the Chemical Changes in the Blood of the Dog After Pyloric and Intestinal Obstruction , J. Exper. Med. 38:55-71 ( (July) ) 1923. 20. MacCallum, W. G.; Lintz, J.; Vermilye, H. N.; Leggett, T. H., and Boas, E.: The Effect of Pyloric Obstruction in Relation to Gastric Tetany , Bull. Johns Hopkins Hosp. 31:1-7 ( (Jan.) ) 1920. 21. Coller, F. A.; Bartlett, R. M.; Bingham, D. L. C.; Maddock, W. G., and Pedersen, S.: Replacement of Sodium Chloride in Surgical Patients , Ann. Surg. 108:769-782 ( (Oct.) ) 1938. 22. McKittrick, L. S., and Sarris, S. P.: Acute Mechanical Obstruction of the Small Bowel: Its Diagnosis and Treatment , New England J. Med. 222:611-622 ( (April 11) ) 1940.

Journal

Archives of Surgery – American Medical Association

Published: Oct 1, 1946

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