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REGENERATION OF SERUM ALBUMIN WITH HYDROLYZED PROTEIN IN CHRONIC HYPOPROTEINEMIA PRODUCED BY DIET: AN EXPERIMENTAL STUDY

REGENERATION OF SERUM ALBUMIN WITH HYDROLYZED PROTEIN IN CHRONIC HYPOPROTEINEMIA PRODUCED BY... Abstract Search of the literature reveals no observations on the parenteral use of hydrolyzed protein in the regeneration of serum albumin in animals depleted of their plasma protein by diets deficient in protein. Such a diet has been used by many previous workers to produce hypoproteinemia. The most extensive studies were those of Weech and co-workers.1 In studies of regeneration, these observers utilized intact proteins, such as meat, serum and casein, but did not employ hydrolyzed protein. Using the Weech diet, Mueller, Kemmerer, Cox and Barnes2 showed regeneration values similar to those attained with casein when hydrolyzed protein was given by mouth. Increases in serum protein concentration were observed in operative patients with hypoproteinemia after the intravenous injection of the same hydrolyzed protein used in the experiments hereinafter described.3 The early experimental and clinical observations with hydrolyzed protein were summarized in a previous paper.4 EXPERIMENTAL PROCEDURE Thirteen References 1. (a) Weech, A. A.; Goettsch, E., and Reeves, E. B.: J. Exper. Med. 61:299, 1935.Crossref 2. (b) Weech, A. A., and Goettsch, E.: Bull. Johns Hopkins Hosp. 63:154 and 181, 1938 3. (c) 64:425, 1939. 4. Mueller, A. J.; Kemmerer, K. S.; Cox, W. M., Jr., and Barnes, S. T.: J. Biol. Chem. 134:573, 1940. 5. Elman, R.: Ann. Surg. 112:594, 1940.Crossref 6. Elman, R., and Weiner, D. O.: Intravenous Alimentation, with Special Reference to Protein (Amino Acid) Metabolism , J. A. M. A. 112:796 ( (March 4) ) 1939.Crossref 7. The vitamin B complex concentrate (Labco) used in three experiments obtained from the Borden Company, Bainbridge, N. Y. 8. The hydrolyzed protein (Amigen) used in these experiments was furnished by Mead Johnson & Co., Evansville, Ind. 9. Sobel, A.; Yuska, H., and Cohen, J.: J. Biol. Chem. 118:443, 1937. 10. Campbell, W. R., and Hanna, M. I.: J. Biol. Chem. 119:15, 1937. 11. Elman, R., and Heifetz, C.: J. Exper. Med. 73:417, 1941.Crossref 12. Weech and Goettsch.1b Mueller, Kemmerer, Cox and Barnes.2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

REGENERATION OF SERUM ALBUMIN WITH HYDROLYZED PROTEIN IN CHRONIC HYPOPROTEINEMIA PRODUCED BY DIET: AN EXPERIMENTAL STUDY

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1942.01210240103007
Publisher site
See Article on Publisher Site

Abstract

Abstract Search of the literature reveals no observations on the parenteral use of hydrolyzed protein in the regeneration of serum albumin in animals depleted of their plasma protein by diets deficient in protein. Such a diet has been used by many previous workers to produce hypoproteinemia. The most extensive studies were those of Weech and co-workers.1 In studies of regeneration, these observers utilized intact proteins, such as meat, serum and casein, but did not employ hydrolyzed protein. Using the Weech diet, Mueller, Kemmerer, Cox and Barnes2 showed regeneration values similar to those attained with casein when hydrolyzed protein was given by mouth. Increases in serum protein concentration were observed in operative patients with hypoproteinemia after the intravenous injection of the same hydrolyzed protein used in the experiments hereinafter described.3 The early experimental and clinical observations with hydrolyzed protein were summarized in a previous paper.4 EXPERIMENTAL PROCEDURE Thirteen References 1. (a) Weech, A. A.; Goettsch, E., and Reeves, E. B.: J. Exper. Med. 61:299, 1935.Crossref 2. (b) Weech, A. A., and Goettsch, E.: Bull. Johns Hopkins Hosp. 63:154 and 181, 1938 3. (c) 64:425, 1939. 4. Mueller, A. J.; Kemmerer, K. S.; Cox, W. M., Jr., and Barnes, S. T.: J. Biol. Chem. 134:573, 1940. 5. Elman, R.: Ann. Surg. 112:594, 1940.Crossref 6. Elman, R., and Weiner, D. O.: Intravenous Alimentation, with Special Reference to Protein (Amino Acid) Metabolism , J. A. M. A. 112:796 ( (March 4) ) 1939.Crossref 7. The vitamin B complex concentrate (Labco) used in three experiments obtained from the Borden Company, Bainbridge, N. Y. 8. The hydrolyzed protein (Amigen) used in these experiments was furnished by Mead Johnson & Co., Evansville, Ind. 9. Sobel, A.; Yuska, H., and Cohen, J.: J. Biol. Chem. 118:443, 1937. 10. Campbell, W. R., and Hanna, M. I.: J. Biol. Chem. 119:15, 1937. 11. Elman, R., and Heifetz, C.: J. Exper. Med. 73:417, 1941.Crossref 12. Weech and Goettsch.1b Mueller, Kemmerer, Cox and Barnes.2

Journal

Archives of SurgeryAmerican Medical Association

Published: Jun 1, 1942

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