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R. Elman, D. Weiner (1939)
INTRAVENOUS ALIMENTATION: WITH SPECIAL REFERENCE TO PROTEIN (AMINO ACID) METABOLISMJAMA, 112
R. Elman, C. Heifetz (1941)
EXPERIMENTAL HYPOALBUMINEMIA : ITS EFFECT ON THE MORPHOLOGY, FUNCTION, AND PROTEIN AND WATER CONTENT OF THE LIVER.Journal of Experimental Medicine, 73
A. Mueller, K. Kemmerer, W. Cox, S. Barnes (1940)
The effect of casein and a casein digest on growth and serum protein regeneration.Journal of Biological Chemistry, 134
A. Sobel, Henry Yuska, J. Cohen (1937)
A CONVENIENT METHOD OF DETERMINING SMALL AMOUNTS OF AMMONIA AND OTHER BASES BY THE USE OF BORIC ACIDJournal of Biological Chemistry, 118
R. Elman (1940)
PARENTERAL REPLACEMENT OF PROTEIN WITH THE AMINO-ACIDS OF HYDROLYZED CASEIN.Annals of surgery, 112 4
W. Campbell, M. Hanna (1937)
THE ALBUMIN, GLOBULINS, AND FIBRINOGEN OF SERUM AND PLASMAJournal of Biological Chemistry, 119
A. Weech, E. Goettsch, E. Reeves (1935)
NUTRITIONAL EDEMA IN THE DOG I. DEVELOPMENT OF HYPOPROTEINEMIA ON A DIET DEFICIENT IN PROTEINJournal of Experimental Medicine, 61
Abstract Search of the literature reveals no observations on the parenteral use of hydrolyzed protein in the regeneration of serum albumin in animals depleted of their plasma protein by diets deficient in protein. Such a diet has been used by many previous workers to produce hypoproteinemia. The most extensive studies were those of Weech and co-workers.1 In studies of regeneration, these observers utilized intact proteins, such as meat, serum and casein, but did not employ hydrolyzed protein. Using the Weech diet, Mueller, Kemmerer, Cox and Barnes2 showed regeneration values similar to those attained with casein when hydrolyzed protein was given by mouth. Increases in serum protein concentration were observed in operative patients with hypoproteinemia after the intravenous injection of the same hydrolyzed protein used in the experiments hereinafter described.3 The early experimental and clinical observations with hydrolyzed protein were summarized in a previous paper.4 EXPERIMENTAL PROCEDURE Thirteen References 1. (a) Weech, A. A.; Goettsch, E., and Reeves, E. B.: J. Exper. Med. 61:299, 1935.Crossref 2. (b) Weech, A. A., and Goettsch, E.: Bull. Johns Hopkins Hosp. 63:154 and 181, 1938 3. (c) 64:425, 1939. 4. Mueller, A. J.; Kemmerer, K. S.; Cox, W. M., Jr., and Barnes, S. T.: J. Biol. Chem. 134:573, 1940. 5. Elman, R.: Ann. Surg. 112:594, 1940.Crossref 6. Elman, R., and Weiner, D. O.: Intravenous Alimentation, with Special Reference to Protein (Amino Acid) Metabolism , J. A. M. A. 112:796 ( (March 4) ) 1939.Crossref 7. The vitamin B complex concentrate (Labco) used in three experiments obtained from the Borden Company, Bainbridge, N. Y. 8. The hydrolyzed protein (Amigen) used in these experiments was furnished by Mead Johnson & Co., Evansville, Ind. 9. Sobel, A.; Yuska, H., and Cohen, J.: J. Biol. Chem. 118:443, 1937. 10. Campbell, W. R., and Hanna, M. I.: J. Biol. Chem. 119:15, 1937. 11. Elman, R., and Heifetz, C.: J. Exper. Med. 73:417, 1941.Crossref 12. Weech and Goettsch.1b Mueller, Kemmerer, Cox and Barnes.2
Archives of Surgery – American Medical Association
Published: Jun 1, 1942
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