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S. Weinhouse (1940)
Atherosclerosis: Lipids of Serum and Tissues in Experimental Atherosclerosis of RabbitsArch. Path., 30
R. Schoenheimer, W. Sperry (1934)
A MICROMETHOD FOR THE DETERMINATION OF FREE AND COMBINED CHOLESTEROLJournal of Biological Chemistry, 106
T. Leary (1934)
Experimental atherosclerosis in the rabbit compared with human (coronary) atherosclerosis., 17
N. Anitschkow (1933)
Arteriosclerosis
L. Dragstedt, C. Vermeulen, W. Goodpasture, P. Donovan, W. Geer (1939)
LIPOCAIC AND FATTY INFILTRATION OF THE LIVER IN PANCREATIC DIABETESJAMA Internal Medicine, 64
L. Dragstedt (1940)
THE PRESENT STATUS OF LIPOCAICJAMA, 114
Abstract If rabbits are fed cholesterol in excessive amounts, a marked and sustained elevation of the blood cholesterol level occurs, and after a few months progressive intimal changes appear in the aorta.1 Cholesterol and other lipids2 are deposited in the inner layers of the aorta, and gradually lesions develop which assume most of the characteristics of human arteriosclerosis.3 These findings suggest that this disease may be the result of some metabolic defect and not a necessary accompaniment of the aging process. The abnormally high incidence of presenile arteriosclerosis in patients with diabetes mellitus supports this view. Here also there is evidence that some disturbance in fat metabolism resulting in sustained hypercholesteremia is involved. Rabinowitch,4 Joslin5 and others have demonstrated that high fat diets given to patients with diabetes favor, and that, conversely, low fat—high carbohydrate diets retard, the appearance of hypercholesteremia and arteriosclerosis. The discovery in References 1. Anitschkow, N., and Cowdry, E. V.: Arteriosclerosis , New York, The Macmillan Company, 1933. 2. Weinhouse, S., and Hirsch, E. F.: Atherosclerosis: Lipids of Serum and Tissues in Experimental Atherosclerosis of Rabbits , Arch. Path. 30:856-867 ( (Oct.) ) 1940. 3. Leary, T.: Experimental Atherosclerosis in Rabbit Compared with Human (Coronary) Atherosclerosis , Arch. Path. 17:453-492 ( (April) ) 1934. 4. Rabinowitch, I. M.: Ann. Int. Med. 8:1436, 1935.Crossref 5. Joslin, E. P.: Ann. Clin. Med. 5:1061, 1927. 6. Dragstedt, L. R.; Clark, D. E.; Julian, O. C.; Vermeulen, C., and Goodpasture, W. C.: Surgery 8:353, 1940. 7. Dragstedt, L. R.: Present Status of Lipocaic , J. A. M. A. 114:29 ( (Jan. 6) ) 1940. 8. Dragstedt, L. R.; Vermeulen, C.; Goodpasture, W. C.; Donovan, P. B., and Geer, W. A.: Lipocaic and Fatty Infiltration of the Liver in Pancreatic Diabetes , Arch. Int. Med. 64:1017 ( (Nov.) ) 1939.Crossref 9. Dragstedt, L. R.: Northwest Med. 37:33, 1938. 10. Dragstedt, L. R.; Van Prohaska, J.; Clark, D. E., and Julian, O. C.: Am. J. Physiol. 129:348, 1940. 11. Huber, M. J.; Broun, G. D., and Casey, A. E.: Proc. Soc. Exper. Biol. & Med. 37:441, 1937. 12. Steiner, A.: Proc. Soc. Exper. Biol. & Med. 38:231, 1938 13. 39:411, 1938. 14. Baumann, C. A., and Rusch, H. P.: Proc. Soc. Exper. Biol. & Med. 38:647, 1938. 15. Alpha Flakes Rabbit Feed. 16. Clark, D. E.; Vermeulen, C.; Donovan, P. B., and Dragstedt, L. R.: Am. J. Physiol. 126:P464, 1939. 17. Schonheimer, R., and Sperry, W. M.: J. Biol. Chem. 106:745, 1934.
Archives of Surgery – American Medical Association
Published: Feb 1, 1942
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