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EFFECT OF THE ADMINISTRATION OF LIPOCAIC AND CHOLESTEROL IN RABBITS

EFFECT OF THE ADMINISTRATION OF LIPOCAIC AND CHOLESTEROL IN RABBITS Abstract If rabbits are fed cholesterol in excessive amounts, a marked and sustained elevation of the blood cholesterol level occurs, and after a few months progressive intimal changes appear in the aorta.1 Cholesterol and other lipids2 are deposited in the inner layers of the aorta, and gradually lesions develop which assume most of the characteristics of human arteriosclerosis.3 These findings suggest that this disease may be the result of some metabolic defect and not a necessary accompaniment of the aging process. The abnormally high incidence of presenile arteriosclerosis in patients with diabetes mellitus supports this view. Here also there is evidence that some disturbance in fat metabolism resulting in sustained hypercholesteremia is involved. Rabinowitch,4 Joslin5 and others have demonstrated that high fat diets given to patients with diabetes favor, and that, conversely, low fat—high carbohydrate diets retard, the appearance of hypercholesteremia and arteriosclerosis. The discovery in References 1. Anitschkow, N., and Cowdry, E. V.: Arteriosclerosis , New York, The Macmillan Company, 1933. 2. Weinhouse, S., and Hirsch, E. F.: Atherosclerosis: Lipids of Serum and Tissues in Experimental Atherosclerosis of Rabbits , Arch. Path. 30:856-867 ( (Oct.) ) 1940. 3. Leary, T.: Experimental Atherosclerosis in Rabbit Compared with Human (Coronary) Atherosclerosis , Arch. Path. 17:453-492 ( (April) ) 1934. 4. Rabinowitch, I. M.: Ann. Int. Med. 8:1436, 1935.Crossref 5. Joslin, E. P.: Ann. Clin. Med. 5:1061, 1927. 6. Dragstedt, L. R.; Clark, D. E.; Julian, O. C.; Vermeulen, C., and Goodpasture, W. C.: Surgery 8:353, 1940. 7. Dragstedt, L. R.: Present Status of Lipocaic , J. A. M. A. 114:29 ( (Jan. 6) ) 1940. 8. Dragstedt, L. R.; Vermeulen, C.; Goodpasture, W. C.; Donovan, P. B., and Geer, W. A.: Lipocaic and Fatty Infiltration of the Liver in Pancreatic Diabetes , Arch. Int. Med. 64:1017 ( (Nov.) ) 1939.Crossref 9. Dragstedt, L. R.: Northwest Med. 37:33, 1938. 10. Dragstedt, L. R.; Van Prohaska, J.; Clark, D. E., and Julian, O. C.: Am. J. Physiol. 129:348, 1940. 11. Huber, M. J.; Broun, G. D., and Casey, A. E.: Proc. Soc. Exper. Biol. & Med. 37:441, 1937. 12. Steiner, A.: Proc. Soc. Exper. Biol. & Med. 38:231, 1938 13. 39:411, 1938. 14. Baumann, C. A., and Rusch, H. P.: Proc. Soc. Exper. Biol. & Med. 38:647, 1938. 15. Alpha Flakes Rabbit Feed. 16. Clark, D. E.; Vermeulen, C.; Donovan, P. B., and Dragstedt, L. R.: Am. J. Physiol. 126:P464, 1939. 17. Schonheimer, R., and Sperry, W. M.: J. Biol. Chem. 106:745, 1934. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

EFFECT OF THE ADMINISTRATION OF LIPOCAIC AND CHOLESTEROL IN RABBITS

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1942.01210200076006
Publisher site
See Article on Publisher Site

Abstract

Abstract If rabbits are fed cholesterol in excessive amounts, a marked and sustained elevation of the blood cholesterol level occurs, and after a few months progressive intimal changes appear in the aorta.1 Cholesterol and other lipids2 are deposited in the inner layers of the aorta, and gradually lesions develop which assume most of the characteristics of human arteriosclerosis.3 These findings suggest that this disease may be the result of some metabolic defect and not a necessary accompaniment of the aging process. The abnormally high incidence of presenile arteriosclerosis in patients with diabetes mellitus supports this view. Here also there is evidence that some disturbance in fat metabolism resulting in sustained hypercholesteremia is involved. Rabinowitch,4 Joslin5 and others have demonstrated that high fat diets given to patients with diabetes favor, and that, conversely, low fat—high carbohydrate diets retard, the appearance of hypercholesteremia and arteriosclerosis. The discovery in References 1. Anitschkow, N., and Cowdry, E. V.: Arteriosclerosis , New York, The Macmillan Company, 1933. 2. Weinhouse, S., and Hirsch, E. F.: Atherosclerosis: Lipids of Serum and Tissues in Experimental Atherosclerosis of Rabbits , Arch. Path. 30:856-867 ( (Oct.) ) 1940. 3. Leary, T.: Experimental Atherosclerosis in Rabbit Compared with Human (Coronary) Atherosclerosis , Arch. Path. 17:453-492 ( (April) ) 1934. 4. Rabinowitch, I. M.: Ann. Int. Med. 8:1436, 1935.Crossref 5. Joslin, E. P.: Ann. Clin. Med. 5:1061, 1927. 6. Dragstedt, L. R.; Clark, D. E.; Julian, O. C.; Vermeulen, C., and Goodpasture, W. C.: Surgery 8:353, 1940. 7. Dragstedt, L. R.: Present Status of Lipocaic , J. A. M. A. 114:29 ( (Jan. 6) ) 1940. 8. Dragstedt, L. R.; Vermeulen, C.; Goodpasture, W. C.; Donovan, P. B., and Geer, W. A.: Lipocaic and Fatty Infiltration of the Liver in Pancreatic Diabetes , Arch. Int. Med. 64:1017 ( (Nov.) ) 1939.Crossref 9. Dragstedt, L. R.: Northwest Med. 37:33, 1938. 10. Dragstedt, L. R.; Van Prohaska, J.; Clark, D. E., and Julian, O. C.: Am. J. Physiol. 129:348, 1940. 11. Huber, M. J.; Broun, G. D., and Casey, A. E.: Proc. Soc. Exper. Biol. & Med. 37:441, 1937. 12. Steiner, A.: Proc. Soc. Exper. Biol. & Med. 38:231, 1938 13. 39:411, 1938. 14. Baumann, C. A., and Rusch, H. P.: Proc. Soc. Exper. Biol. & Med. 38:647, 1938. 15. Alpha Flakes Rabbit Feed. 16. Clark, D. E.; Vermeulen, C.; Donovan, P. B., and Dragstedt, L. R.: Am. J. Physiol. 126:P464, 1939. 17. Schonheimer, R., and Sperry, W. M.: J. Biol. Chem. 106:745, 1934.

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1942

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