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HEPATIC DAMAGE IN BILIARY DISEASE: ITS RELATION TO THE CONCENTRATION OF BILE ACIDS IN THE BILE

HEPATIC DAMAGE IN BILIARY DISEASE: ITS RELATION TO THE CONCENTRATION OF BILE ACIDS IN THE BILE Abstract It seems plausible that the decrease in the capacity of the liver to concentrate bile acids (taurocholic and glycocholic acids and their salts) in the bile should be an index to the amount of hepatic damage present. Bollman and Mann1 have shown that bile acids are produced, destroyed and concentrated in and only by the liver. Smyth and Whipple,2 as well as Bollman and Mann, have shown that small doses of substances known to be hepatotoxins, that is, chloroform, carbon tetrachloride and tetrachlorethylene, inhibit the function of the liver of the dog in producing and concentrating bile acids. Walters, Greene, and Frederickson3 studied the constituents of the bile of a series of patients who had been operated on for biliary disease. They noticed that a decrease in the concentration of bile acids in the bile followed operations on the biliary system. Mann and two of us (McGowan References 1. Bollman, J. L., and Mann, F. C.: The Influence of the Liver in the Formation and Destruction of Bile Salts , Am. J. Physiol. 116:214-224 ( (June) ) 1936. 2. Smyth, F. S., and Whipple, G. H.: Bile Salt Metabolism: I. Influence of Chloroform and Phosphorus on Bile Fistula Dogs; II Proteose and X-Ray Intoxication: Thyroid and Thyroxin , J. Biol. Chem. 59:623-646 ( (April) ) 1924. 3. Walters, W.; Greene, C. H., and Frederickson, C. H.: The Composition of the Bile Following the Relief of Biliary Obstruction: Report of a Series of Illustrative Cases , Ann. Surg. 91:686-693 ( (May) ) 1930.Crossref 4. McGowan, J. M.; Bollman, J. L., and Mann, F. C.: The Bile Acids in Icterus Produced by Toluylenediamine , J. Pharmacol. & Exper. Therap. 58:305-311 ( (Nov.) ) 1936. 5. Ravdin, I. S.; Johnston, C. G.; Riegel, C., and Wright, S. L.: A Study of Human Liver Bile After Release of Common Duct Obstruction , J. Clin. Investigation 12:659-672 ( (July) ) 1933. 6. Walters, W., and Thiessen, N. W.: Visual Methods of Studying the Physiology of the Common Bile Duct: I. The Problem of Pancreatitis and Sphincteritis , Proc. Staff Meet., Mayo Clin. 9:772-775 ( (Dec. 19) ) 1934. 7. McGowan, J. M.; Butsch, W. L., and Walters, W.: Pressure in the Common Bile Duct of Man: Its Relation to Pain Following Cholecystectomy , J. A. M. A. 106:2227-2230 ( (June 27) ) 1936. 8. Gregory, R., and Pascoe, T. A.: The Quantitative Determination of Bile Acids by Means of a New Color Reaction and Monochromatic Light , J. Biol. Chem. 83:35-42 ( (July) ) 1929. 9. Snell, A. M.: The Effects of Calculous Biliary Obstruction on the Structure and Functions of the Liver , Surg., Gynec. & Obst. 63:596-602 ( (Nov.) ) 1936. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

HEPATIC DAMAGE IN BILIARY DISEASE: ITS RELATION TO THE CONCENTRATION OF BILE ACIDS IN THE BILE

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1938 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1938.01200050096007
Publisher site
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Abstract

Abstract It seems plausible that the decrease in the capacity of the liver to concentrate bile acids (taurocholic and glycocholic acids and their salts) in the bile should be an index to the amount of hepatic damage present. Bollman and Mann1 have shown that bile acids are produced, destroyed and concentrated in and only by the liver. Smyth and Whipple,2 as well as Bollman and Mann, have shown that small doses of substances known to be hepatotoxins, that is, chloroform, carbon tetrachloride and tetrachlorethylene, inhibit the function of the liver of the dog in producing and concentrating bile acids. Walters, Greene, and Frederickson3 studied the constituents of the bile of a series of patients who had been operated on for biliary disease. They noticed that a decrease in the concentration of bile acids in the bile followed operations on the biliary system. Mann and two of us (McGowan References 1. Bollman, J. L., and Mann, F. C.: The Influence of the Liver in the Formation and Destruction of Bile Salts , Am. J. Physiol. 116:214-224 ( (June) ) 1936. 2. Smyth, F. S., and Whipple, G. H.: Bile Salt Metabolism: I. Influence of Chloroform and Phosphorus on Bile Fistula Dogs; II Proteose and X-Ray Intoxication: Thyroid and Thyroxin , J. Biol. Chem. 59:623-646 ( (April) ) 1924. 3. Walters, W.; Greene, C. H., and Frederickson, C. H.: The Composition of the Bile Following the Relief of Biliary Obstruction: Report of a Series of Illustrative Cases , Ann. Surg. 91:686-693 ( (May) ) 1930.Crossref 4. McGowan, J. M.; Bollman, J. L., and Mann, F. C.: The Bile Acids in Icterus Produced by Toluylenediamine , J. Pharmacol. & Exper. Therap. 58:305-311 ( (Nov.) ) 1936. 5. Ravdin, I. S.; Johnston, C. G.; Riegel, C., and Wright, S. L.: A Study of Human Liver Bile After Release of Common Duct Obstruction , J. Clin. Investigation 12:659-672 ( (July) ) 1933. 6. Walters, W., and Thiessen, N. W.: Visual Methods of Studying the Physiology of the Common Bile Duct: I. The Problem of Pancreatitis and Sphincteritis , Proc. Staff Meet., Mayo Clin. 9:772-775 ( (Dec. 19) ) 1934. 7. McGowan, J. M.; Butsch, W. L., and Walters, W.: Pressure in the Common Bile Duct of Man: Its Relation to Pain Following Cholecystectomy , J. A. M. A. 106:2227-2230 ( (June 27) ) 1936. 8. Gregory, R., and Pascoe, T. A.: The Quantitative Determination of Bile Acids by Means of a New Color Reaction and Monochromatic Light , J. Biol. Chem. 83:35-42 ( (July) ) 1929. 9. Snell, A. M.: The Effects of Calculous Biliary Obstruction on the Structure and Functions of the Liver , Surg., Gynec. & Obst. 63:596-602 ( (Nov.) ) 1936.

Journal

Archives of Surgery – American Medical Association

Published: Nov 1, 1938

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