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EFFECT OF STARVATION ON THE HEALING OF FRACTURES IN RABBITS

EFFECT OF STARVATION ON THE HEALING OF FRACTURES IN RABBITS Abstract Prolonged abstinence from foods providing certain essentials to normal life processes results in various well known deficiency diseases which must be distinguished from changes arising in normal animals suddenly deprived of all food intake. For purposes of clarity the former may be regarded as changes arising from chronic starvation and the latter as those arising from acute starvation. It is with healing in diseases arising from acute starvation that this paper is concerned. A review of the literature reveals that investigators unanimously agree that acute starvation does not inhibit either growth or repair. McCollum and his co-workers1 demonstrated that fasting would cause active rickets in rats to heal from within twenty-four to forty-eight hours. Shipley and Holt2 reported studies in vitro and stated that solutions to which 51.3 millimols of sodium chloride had been added inhibited calcification in preparations of the bones of rats with rickets, while similar References 1. McCollum, E. V.; Simmonds, N.; Shipley, P. G., and Park, E. A.: The Effect of Starvation on the Healing of Rickets , Bull. Johns Hopkins Hosp. 33:31, 1922. 2. Shipley, P. G., and Holt, L. E., Jr.: Effect of Starvation on Healing of Rickets in Rats , Proc. Soc. Exper. Biol. & Med. 25:32, 1927. 3. Howes, E. L.; Briggs, H.; Shea, R., and Harvey, S. C.: Effect of Complete and Partial Starvation on the Rate of Fibroplasia in the Healing Wound , Arch. Surg. 27:846 ( (Nov.) ) 1933. 4. Roegholt, M. N.: Influence of Diet Free from Vitamin A on Myelopoiesis and the White Blood Picture and Its Effect on Wound Healing , Nederl. tijdschr. v. geneesk. 2:3744 ( (Aug. 10) ) 1929. 5. Morgan, Thomas H.: The Physiology of Regeneration , J. Exper. Zoöl. 3:457, 1906. 6. (a) Morgulis, S.; Howes, P. E., and Hawk, P. B.: Studies on Tissues of Fasting Animals , Biol. Bull. 28:397, 1915. 7. (b) Morgulis, S.: Fasting and Undernutrition: A Biological and Sociological Study of Inanition , New York, E. P. Dutton & Company, 1923. 8. Gaglio, G.: Sulle alterazioni istologiche e funzionali dei muscoli durante l'inanizione , Arch. per le sc. med. 7:301, 1884 9. Morpurgo, B.: Sull processo fisiologico di neoformazione callulare durante la inanizione acute dell' organismo , Arch. per le sc. med. 12:395, 1888 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

EFFECT OF STARVATION ON THE HEALING OF FRACTURES IN RABBITS

Archives of Surgery , Volume 35 (3) – Sep 1, 1937

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1937.01190150075007
Publisher site
See Article on Publisher Site

Abstract

Abstract Prolonged abstinence from foods providing certain essentials to normal life processes results in various well known deficiency diseases which must be distinguished from changes arising in normal animals suddenly deprived of all food intake. For purposes of clarity the former may be regarded as changes arising from chronic starvation and the latter as those arising from acute starvation. It is with healing in diseases arising from acute starvation that this paper is concerned. A review of the literature reveals that investigators unanimously agree that acute starvation does not inhibit either growth or repair. McCollum and his co-workers1 demonstrated that fasting would cause active rickets in rats to heal from within twenty-four to forty-eight hours. Shipley and Holt2 reported studies in vitro and stated that solutions to which 51.3 millimols of sodium chloride had been added inhibited calcification in preparations of the bones of rats with rickets, while similar References 1. McCollum, E. V.; Simmonds, N.; Shipley, P. G., and Park, E. A.: The Effect of Starvation on the Healing of Rickets , Bull. Johns Hopkins Hosp. 33:31, 1922. 2. Shipley, P. G., and Holt, L. E., Jr.: Effect of Starvation on Healing of Rickets in Rats , Proc. Soc. Exper. Biol. & Med. 25:32, 1927. 3. Howes, E. L.; Briggs, H.; Shea, R., and Harvey, S. C.: Effect of Complete and Partial Starvation on the Rate of Fibroplasia in the Healing Wound , Arch. Surg. 27:846 ( (Nov.) ) 1933. 4. Roegholt, M. N.: Influence of Diet Free from Vitamin A on Myelopoiesis and the White Blood Picture and Its Effect on Wound Healing , Nederl. tijdschr. v. geneesk. 2:3744 ( (Aug. 10) ) 1929. 5. Morgan, Thomas H.: The Physiology of Regeneration , J. Exper. Zoöl. 3:457, 1906. 6. (a) Morgulis, S.; Howes, P. E., and Hawk, P. B.: Studies on Tissues of Fasting Animals , Biol. Bull. 28:397, 1915. 7. (b) Morgulis, S.: Fasting and Undernutrition: A Biological and Sociological Study of Inanition , New York, E. P. Dutton & Company, 1923. 8. Gaglio, G.: Sulle alterazioni istologiche e funzionali dei muscoli durante l'inanizione , Arch. per le sc. med. 7:301, 1884 9. Morpurgo, B.: Sull processo fisiologico di neoformazione callulare durante la inanizione acute dell' organismo , Arch. per le sc. med. 12:395, 1888

Journal

Archives of SurgeryAmerican Medical Association

Published: Sep 1, 1937

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