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EXPERIMENTAL SHOCK: XI. A STUDY OF THE ALTERATIONS IN THE VOLUME OF BLOOD AND IN THE WATER CONTENT OF BLOOD AND OF MUSCLE THAT ARE PRODUCED BY HISTAMINE

EXPERIMENTAL SHOCK: XI. A STUDY OF THE ALTERATIONS IN THE VOLUME OF BLOOD AND IN THE WATER... Abstract The possibility that histamine is the cause of "shock" after trauma has been extensively speculated on in recent years. Keith1 and others have found that severe injuries are followed by a diminution of the volume of blood. Harris and one of us (Dr. Blalock)2 found that trauma to the muscles and to the intestines and burns are associated with a decrease in the water in the blood and in the muscles other than those at the sites of the injuries. The study indicated that the loss of fluid from the blood stream into and from the traumatized areas was responsible for the concentration of the blood. It is known that histamine causes an increase in the concentration of the blood. Since histamine causes a general dilatation of capillaries and possibly an increase in their permeability, it was believed that histamine would probably cause a general loss of fluid References 1. Keith, N. M.: Report of Shock Committee, London Medical Research Committee, 1919, no. 27. 2. Harris, P. N., and Blalock, A.: Experimental Shock: X. Observations on the Water Content of the Tissues of the Body After Trauma and After Hemorrhage , Arch. Surg. 22:638 ( (April) ) 1931.Crossref 3. Keith, N. M.; Rowntree, L. G., and Geraghty, J. T.: A Method for the Determination of Plasma and Blood Volume , Arch. Int. Med. 16:547 ( (Oct.) ) 1915.Crossref 4. Rowntree; Brown, and Roth: The Volume of the Blood and Plasma, Mayo Clinic Monographs , Philadelphia, W. B. Saunders Company, 1929. 5. Newcomer, H. S.: J. Biol. Chem. 37:465, 1919. 6. Whitehorn, J. C.: A System of Blood Analysis , J. Biol. Chem. 45:449, 1920. 7. Engels, W.: Arch. f. exper. Path. u. Pharmakol. 51:346, 1904.Crossref 8. Durig, A.: Wassergehalt und Organfunction , Arch. f. d. ges. Physiol. 85:401, 1901.Crossref 9. Tobler, L.: Zur Kenntnis des Chemismus akuter Gewichtstürze , Arch. f. exper. Path. u. Pharmakol. 62:431, 1910.Crossref 10. Marriott, W. McKim: Anhydremia , Physiol. Rev. 3:275, 1923. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

EXPERIMENTAL SHOCK: XI. A STUDY OF THE ALTERATIONS IN THE VOLUME OF BLOOD AND IN THE WATER CONTENT OF BLOOD AND OF MUSCLE THAT ARE PRODUCED BY HISTAMINE

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1931 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1931.01160110139007
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Abstract

Abstract The possibility that histamine is the cause of "shock" after trauma has been extensively speculated on in recent years. Keith1 and others have found that severe injuries are followed by a diminution of the volume of blood. Harris and one of us (Dr. Blalock)2 found that trauma to the muscles and to the intestines and burns are associated with a decrease in the water in the blood and in the muscles other than those at the sites of the injuries. The study indicated that the loss of fluid from the blood stream into and from the traumatized areas was responsible for the concentration of the blood. It is known that histamine causes an increase in the concentration of the blood. Since histamine causes a general dilatation of capillaries and possibly an increase in their permeability, it was believed that histamine would probably cause a general loss of fluid References 1. Keith, N. M.: Report of Shock Committee, London Medical Research Committee, 1919, no. 27. 2. Harris, P. N., and Blalock, A.: Experimental Shock: X. Observations on the Water Content of the Tissues of the Body After Trauma and After Hemorrhage , Arch. Surg. 22:638 ( (April) ) 1931.Crossref 3. Keith, N. M.; Rowntree, L. G., and Geraghty, J. T.: A Method for the Determination of Plasma and Blood Volume , Arch. Int. Med. 16:547 ( (Oct.) ) 1915.Crossref 4. Rowntree; Brown, and Roth: The Volume of the Blood and Plasma, Mayo Clinic Monographs , Philadelphia, W. B. Saunders Company, 1929. 5. Newcomer, H. S.: J. Biol. Chem. 37:465, 1919. 6. Whitehorn, J. C.: A System of Blood Analysis , J. Biol. Chem. 45:449, 1920. 7. Engels, W.: Arch. f. exper. Path. u. Pharmakol. 51:346, 1904.Crossref 8. Durig, A.: Wassergehalt und Organfunction , Arch. f. d. ges. Physiol. 85:401, 1901.Crossref 9. Tobler, L.: Zur Kenntnis des Chemismus akuter Gewichtstürze , Arch. f. exper. Path. u. Pharmakol. 62:431, 1910.Crossref 10. Marriott, W. McKim: Anhydremia , Physiol. Rev. 3:275, 1923.

Journal

Archives of Surgery – American Medical Association

Published: Nov 1, 1931

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