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PROBABLE INFLUENCE OF PANCREATIC JUICE IN THE REGULATION OF GASTRIC ACIDITY

PROBABLE INFLUENCE OF PANCREATIC JUICE IN THE REGULATION OF GASTRIC ACIDITY Abstract Drainage of the total external secretion of the pancreas, as already reported in a previous communication,1 leads to increasingly severe vomiting in a few days, and, in about a week, to a fatal outcome. In the attempt to explain these symptoms of gastric irritability, a number of observations were made. The contents of the stomach were examined in most of the animals, and the behavior of gastric acidity was studied in a special way. The results will be presented in detail. They have suggested among other things that a reciprocal relationship exists between the alkaline pancreatic juice and the acid secretion of the stomach. One aspect of this relationship has long been known, and the data herein contained adds further proof, that is, that the acid gastric juice, passed into the duodenum, is the normal stimulus of pancreatic secretion. Its discovery by Dolinsky2 in Pavlov's laboratory has been References 1. Elman, R., and McCaughan, J. M.: J. Exper. Med. 45:561, 1927.Crossref 2. Dolinsky, J. L.: Diss., St. Petersburg, 1894. 3. Boldyreff, W.: Ergebn. d. Physiol. 11:121, 1911.Crossref 4. Boldyreff, W.: Quart. J. Exper. Physiol. 8:1, 1914. 5. Apperly, F. L., and Cameron, G.: Med. J. Australia 1:521, 1923. 6. Migay, F., quoted by Babkin, B. P.: Diss., St. Petersburg, 1909 7. Die äussere Sekretion der Verdaungstruse, 1914, p. 382. 8. Pavlov, J. P.: The work of the Digestive Glands , London, C. Griffin & Company, 1910, p. 32. 9. Carlson, A. J.: Am. J. Physiol. 33:248, 1915. 10. Rehfuss, M. E., and Hawk, P. B.: Gastro-Intestinal Studies , J. A. M. A. 63:2088 ( (Dec. 12) ) 1914.Crossref 11. Hollander, F.: Proc. Am. Soc. Biol. Chem., J. Biol. Chem. 74:23, 1927. 12. Kahn, J., and Yaure, G.: Arch. f. d. ges. Physiol. 206:119, 1924.Crossref 13. Ortner, A.: Arch. f. d. ges. Physiol. 186:124, 1917.Crossref 14. Drury, D. R.; McMaster, P. D., and Rous, P.: J. Exper. Med. 39: 403, 1924.Crossref 15. Eisen, P.: Radiol. 4:388, 1923. 16. Bolton, C., and Salmond, R. W. A.: Lancet 1:1230. 1927.Crossref 17. McMaster, P. D., and Elman, R.: J. Exper. Med. 44:173, 1926.Crossref 18. Copher, G. H.., and Kodama, S.: Regulation of Flow of Bile and Pancreatic Juice in Duodenum , Arch. Int. Med. 38:647 ( (Nov.) ) 1926.Crossref 19. Alvarez, W. C.: The Mechanics of the Digestive Tract , New York, Paul B. Hoeber, 1922. 20. Boas, J.: Ztschr. f. klin. Med. 17:155, 1890. 21. Mahlenbrey, J.: Zentralbl. f. d. ges. Physiol. u. Path. d. Stoffwechs. 4: 643, 1909. 22. Rehfuss, M. E., and Hawk, P. B.: Gastric Analysis: Interdigestive Phase or Principle Governing the Resting Stomach , J. A. M. A. 76: 564 ( (Feb. 26) ) 1921. 23. Spencer, W. H.; Meyer, G. P.; Rehfuss, M. E., and Hawk, P. B.: Am. J. Physiol. 39:459, 1916. 24. Iwanow, W.: Arch. f. Verdauungskr. 38:223, 1926.Crossref 25. Kuda, T.: Biochem. Ztschr. 15:473, 1909. 26. Deutsch, G., and Rurup, H.: Deutsches Arch. f. klin. Med. 138:165, 1922. 27. Kern, R. A.; Rose, E., and Austin, J. H.: J. Clin. Investigation 11: 545, 1926.Crossref 28. Wright, C. B., and Medes, G.: Proc. Soc. Exper. Biol. & Med. 24: 904, 1927. 29. Olch, I. Y.: Arch. Surg., to be published. 30. Lewisohn, R., and Guinzburg, L.: Surg. Gynec. Obst. 44:344, 1927. 31. Lorenz, H., and Schur, H.: Arch. f. klin. Chir. 119:239, 1922. 32. Wilcox, W. H.: Quart. J. Med. 3:73, 1909. 33. Bohmansson, G.: Acta chir. Scandinav. 60: 137, 1920, (suppl. 7) . 34. Lewisohn and Guinzburg (footnote 26, first reference). Heinbecker, Peter: Unpublished data from the Presbyterian Hospital, New York, 1926. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

PROBABLE INFLUENCE OF PANCREATIC JUICE IN THE REGULATION OF GASTRIC ACIDITY

Archives of Surgery , Volume 16 (6) – Jun 1, 1928

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1928.01140060131009
Publisher site
See Article on Publisher Site

Abstract

Abstract Drainage of the total external secretion of the pancreas, as already reported in a previous communication,1 leads to increasingly severe vomiting in a few days, and, in about a week, to a fatal outcome. In the attempt to explain these symptoms of gastric irritability, a number of observations were made. The contents of the stomach were examined in most of the animals, and the behavior of gastric acidity was studied in a special way. The results will be presented in detail. They have suggested among other things that a reciprocal relationship exists between the alkaline pancreatic juice and the acid secretion of the stomach. One aspect of this relationship has long been known, and the data herein contained adds further proof, that is, that the acid gastric juice, passed into the duodenum, is the normal stimulus of pancreatic secretion. Its discovery by Dolinsky2 in Pavlov's laboratory has been References 1. Elman, R., and McCaughan, J. M.: J. Exper. Med. 45:561, 1927.Crossref 2. Dolinsky, J. L.: Diss., St. Petersburg, 1894. 3. Boldyreff, W.: Ergebn. d. Physiol. 11:121, 1911.Crossref 4. Boldyreff, W.: Quart. J. Exper. Physiol. 8:1, 1914. 5. Apperly, F. L., and Cameron, G.: Med. J. Australia 1:521, 1923. 6. Migay, F., quoted by Babkin, B. P.: Diss., St. Petersburg, 1909 7. Die äussere Sekretion der Verdaungstruse, 1914, p. 382. 8. Pavlov, J. P.: The work of the Digestive Glands , London, C. Griffin & Company, 1910, p. 32. 9. Carlson, A. J.: Am. J. Physiol. 33:248, 1915. 10. Rehfuss, M. E., and Hawk, P. B.: Gastro-Intestinal Studies , J. A. M. A. 63:2088 ( (Dec. 12) ) 1914.Crossref 11. Hollander, F.: Proc. Am. Soc. Biol. Chem., J. Biol. Chem. 74:23, 1927. 12. Kahn, J., and Yaure, G.: Arch. f. d. ges. Physiol. 206:119, 1924.Crossref 13. Ortner, A.: Arch. f. d. ges. Physiol. 186:124, 1917.Crossref 14. Drury, D. R.; McMaster, P. D., and Rous, P.: J. Exper. Med. 39: 403, 1924.Crossref 15. Eisen, P.: Radiol. 4:388, 1923. 16. Bolton, C., and Salmond, R. W. A.: Lancet 1:1230. 1927.Crossref 17. McMaster, P. D., and Elman, R.: J. Exper. Med. 44:173, 1926.Crossref 18. Copher, G. H.., and Kodama, S.: Regulation of Flow of Bile and Pancreatic Juice in Duodenum , Arch. Int. Med. 38:647 ( (Nov.) ) 1926.Crossref 19. Alvarez, W. C.: The Mechanics of the Digestive Tract , New York, Paul B. Hoeber, 1922. 20. Boas, J.: Ztschr. f. klin. Med. 17:155, 1890. 21. Mahlenbrey, J.: Zentralbl. f. d. ges. Physiol. u. Path. d. Stoffwechs. 4: 643, 1909. 22. Rehfuss, M. E., and Hawk, P. B.: Gastric Analysis: Interdigestive Phase or Principle Governing the Resting Stomach , J. A. M. A. 76: 564 ( (Feb. 26) ) 1921. 23. Spencer, W. H.; Meyer, G. P.; Rehfuss, M. E., and Hawk, P. B.: Am. J. Physiol. 39:459, 1916. 24. Iwanow, W.: Arch. f. Verdauungskr. 38:223, 1926.Crossref 25. Kuda, T.: Biochem. Ztschr. 15:473, 1909. 26. Deutsch, G., and Rurup, H.: Deutsches Arch. f. klin. Med. 138:165, 1922. 27. Kern, R. A.; Rose, E., and Austin, J. H.: J. Clin. Investigation 11: 545, 1926.Crossref 28. Wright, C. B., and Medes, G.: Proc. Soc. Exper. Biol. & Med. 24: 904, 1927. 29. Olch, I. Y.: Arch. Surg., to be published. 30. Lewisohn, R., and Guinzburg, L.: Surg. Gynec. Obst. 44:344, 1927. 31. Lorenz, H., and Schur, H.: Arch. f. klin. Chir. 119:239, 1922. 32. Wilcox, W. H.: Quart. J. Med. 3:73, 1909. 33. Bohmansson, G.: Acta chir. Scandinav. 60: 137, 1920, (suppl. 7) . 34. Lewisohn and Guinzburg (footnote 26, first reference). Heinbecker, Peter: Unpublished data from the Presbyterian Hospital, New York, 1926.

Journal

Archives of SurgeryAmerican Medical Association

Published: Jun 1, 1928

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