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PRELIMINARY MEDICATION IN GENERAL ANESTHESIA: WITH SPECIAL REFERENCE TO THE MARGIN OF SAFETY AND POSTOPERATIVE LESIONS OF THE LUNG

PRELIMINARY MEDICATION IN GENERAL ANESTHESIA: WITH SPECIAL REFERENCE TO THE MARGIN OF SAFETY AND... Abstract The reasons for giving preliminary medication are: to prevent psychic shock, to increase the margin of safety, to modify or abolish any and all untoward symptoms during induction and maintenance of anesthesia and after operation, and, most important of all, to prevent possible pathologic lesions in the lungs. Preliminary medication should be given regardless of whether the anesthesia is local, spinal, regional or general. In the search for a suitable agent for preliminary medication, magnesium sulphate should be considered. It synergizes with morphine by prolonging its effect, and if ether is used, the magnesium sulphate deepens the anesthesia. Table 1 is a summary of cases from more than 200 similar cases selected in sequence at the Presbyterian Hospital of New York City in which 400 cc. of a sterile 4 per cent chemically pure magnesium sulphate solution (4 drachms [15.5 Gm.] of the salt) was given by hypodermoclysis one and References 1. Gwathmey, J. T., and Greenough, James: Synergistic Analgesia with Nitrous Oxide—Oxygen and Magnesium Sulphate , M. Rec. 100:583 ( (Oct. 1) ) 1921. 2. Smythe, F. D.: Further Experiences with Synergistic Analgesia , J. Tennessee M. A. 15:97 ( (June) ) 1922 3. Synergistic Analgesia , Am. J. Surg., anesthesia supp. 37:85 ( (July) ) 1923. 4. Coburn, R. C.: Blood Pressure in Operative Surgery and General Anesthesia , J. A. M. A. 82:1748 ( (May 31) ) 1924.Crossref 5. Gwathmey, J. T., and Hooper, C. W.: Synergistic Analgesia and Anesthesia with Special Reference to Magnesium Sulphate, Ether, Morphine and Novocaine , J. Lab. & Clin. Med. 10:641 ( (May) ) 1925. 6. Davis, A. B.: Amelioration of Labor Pains by Morphine-Magnesium Sulphate Injections and Colonic Instillations , Surg. Gynec. Obst. 40:868 ( (June) ) 1925. 7. Harrar, J. A.: Rectal Ether Analgesia in Labor , Am. J. Obst. & Gynec. 13:486 ( (April) ) 1927. 8. Gwathmey, J. T.: Ethylene and Preliminary Medication , Arch. Surg. 10:568 ( (Jan.) ) 1925. 9. Gwathmey, J. T.: Anesthesia Reviewed , New York M. J. 104:825 ( (Oct. 28) ) 1916 10. 104:895 (Nov. 4) 1916. 11. Gwathmey, J. T., and Hooper, C. W.: Newer Methods of Preliminary Medication , Proc. Inter-State Post Graduate Medical Assembly of North America 88:94 ( (Oct. 12) ) 1925. 12. Nelson's Loose Leaf Surgery, vol. 9, opposite p. 514. 13. Wilson, S. R.: Ether Convulsions , Lancet 1:1117 ( (May 28) ) 1927. 14. Gwathmey, J. T.: Ether Convulsions , Lancet 1:1369 ( (June 25) ) 1927. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

PRELIMINARY MEDICATION IN GENERAL ANESTHESIA: WITH SPECIAL REFERENCE TO THE MARGIN OF SAFETY AND POSTOPERATIVE LESIONS OF THE LUNG

GWATHMEY, JAMES T.; HOOPER, CHARLES W.
Archives of Surgery , Volume 16 (1) – Jan 1, 1928
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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1928.01140010420027
Publisher site
See Article on Publisher Site

Abstract

Abstract The reasons for giving preliminary medication are: to prevent psychic shock, to increase the margin of safety, to modify or abolish any and all untoward symptoms during induction and maintenance of anesthesia and after operation, and, most important of all, to prevent possible pathologic lesions in the lungs. Preliminary medication should be given regardless of whether the anesthesia is local, spinal, regional or general. In the search for a suitable agent for preliminary medication, magnesium sulphate should be considered. It synergizes with morphine by prolonging its effect, and if ether is used, the magnesium sulphate deepens the anesthesia. Table 1 is a summary of cases from more than 200 similar cases selected in sequence at the Presbyterian Hospital of New York City in which 400 cc. of a sterile 4 per cent chemically pure magnesium sulphate solution (4 drachms [15.5 Gm.] of the salt) was given by hypodermoclysis one and References 1. Gwathmey, J. T., and Greenough, James: Synergistic Analgesia with Nitrous Oxide—Oxygen and Magnesium Sulphate , M. Rec. 100:583 ( (Oct. 1) ) 1921. 2. Smythe, F. D.: Further Experiences with Synergistic Analgesia , J. Tennessee M. A. 15:97 ( (June) ) 1922 3. Synergistic Analgesia , Am. J. Surg., anesthesia supp. 37:85 ( (July) ) 1923. 4. Coburn, R. C.: Blood Pressure in Operative Surgery and General Anesthesia , J. A. M. A. 82:1748 ( (May 31) ) 1924.Crossref 5. Gwathmey, J. T., and Hooper, C. W.: Synergistic Analgesia and Anesthesia with Special Reference to Magnesium Sulphate, Ether, Morphine and Novocaine , J. Lab. & Clin. Med. 10:641 ( (May) ) 1925. 6. Davis, A. B.: Amelioration of Labor Pains by Morphine-Magnesium Sulphate Injections and Colonic Instillations , Surg. Gynec. Obst. 40:868 ( (June) ) 1925. 7. Harrar, J. A.: Rectal Ether Analgesia in Labor , Am. J. Obst. & Gynec. 13:486 ( (April) ) 1927. 8. Gwathmey, J. T.: Ethylene and Preliminary Medication , Arch. Surg. 10:568 ( (Jan.) ) 1925. 9. Gwathmey, J. T.: Anesthesia Reviewed , New York M. J. 104:825 ( (Oct. 28) ) 1916 10. 104:895 (Nov. 4) 1916. 11. Gwathmey, J. T., and Hooper, C. W.: Newer Methods of Preliminary Medication , Proc. Inter-State Post Graduate Medical Assembly of North America 88:94 ( (Oct. 12) ) 1925. 12. Nelson's Loose Leaf Surgery, vol. 9, opposite p. 514. 13. Wilson, S. R.: Ether Convulsions , Lancet 1:1117 ( (May 28) ) 1927. 14. Gwathmey, J. T.: Ether Convulsions , Lancet 1:1369 ( (June 25) ) 1927.

Journal

Archives of Surgery – American Medical Association

Published: Jan 1, 1928

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