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INFLUENCE OF THE LIVER ON TOXICITY OF BILE

INFLUENCE OF THE LIVER ON TOXICITY OF BILE Abstract The fact that bile peritonitis is highly fatal has long been recognized by surgeons. It has been demonstrated repeatedly that bile injected intravenously or intraperitoneally into animals is toxic. The first extensive study of this subject was made by von Dusch1 in 1854. Since that time many valuable contributions have been made, but a great deal of the pathology remains unexplained. Bunting and Brown2 either cut the gallbladder of rabbits and allowed the bile to escape into the peritoneal cavity or injected intraperitoneally from 0.25 to 0.5 cc. of bile per kilogram of body weight. Death occurred in less than twenty-four hours and was attributed to direct action on the myocardium, which revealed degenerative changes. The local pathologic effects which were observed may be summarized in the statement that bile produced necrosis of every type of tissue with which it came in contact. This work was repeated by References 1. Von Dusch, T.: Habilitationschrift, Leipzig, 1854. 2. Bunting, C. H., and Brown, W. H.: The Pathology of Intraperitoneal Bile Injections in the Rabbit , J. Exper. Med. 14:445, 1911.Crossref 3. Frothingham, C., and Minot, G. R.: The Effect of Injection of Bovine Bile into Rabbits , J. M. Research 27:79, 1912. 4. Meltzer, S. J., and Salant, W.: Studies on the Toxicity of Bile , J. Exper. Med. 7:280, 1905.Crossref 5. King, J. H., and Stewart, H. A.: Effect of the Injection of Bile on the Circulation , J. Exper. Med. 11:673, 1909.Crossref 6. King, J. H.; Bigelow, J. E., and Pearce, L.: Experimental Obstructive Jaundice , J. Exper. Med. 14:59, 1911.Crossref 7. Mann, F. C.: Sheard, C.: Bollman, J. L., and Baldes, J.: The Site of the Formation of Bilirubin , Am. J. Physiol. 74:497 ( (Nov.) ) 1925. 8. Rich, A. R.: On the Extrahepatic Formation of Bile Pigment , Bull. Johns Hopkins Hosp. 36:233 ( (April) ) 1925. 9. Buys, E.: Contribution à l'étude de l'action déstructive exercée par le foie sur certains alcaloides , Ann. Soc. Roy. d. sc. méd. et nat. de Bruxelles 4:73, 1895. 10. Cloelta, M.: Ueber das Verhalten des Atropins bei verschieden empfindlichen Tierarten , Arch. f. Exper. Path. u. Pharmkol. supp. vol. 119, 1908. 11. Dixon, W. E., and Lee, W. E.: Tolerance to Nicotine , Quart. J. Exper. Physiol. 5:373, 1912. 12. Edmunds, C. W., and Smith, M. I.: Further Studies in Nicotine Tolerance , J. Lab. & Clin. Med. 1:315, 1915. 13. Weiss, S., and Hatcher, R. A.: Studies on Strychnin , J. Pharmacol. & Exper. Therap. 19:419, 1922. 14. Falls, F. H.: Allergic Phenomena Following Intraportal Injections , J. Infect. Dis. 22:83, 1918. 15. Manwaring, W. H., and Crowe, H. E.: Rôle of Hepatic Tissues in the Acute Anaphylactic Reaction , J. Immunol. 2:517, 1917. 16. McNee, J. W.: Jaundice, a Review of Recent Work , Quart. J. Med. 16:390, 1923. 17. Clark, E. P., and Collip, J. B.: Tisdall Method for Determination of Blood Serum Calcium with a Suggested Modification , J. Biol. Chem. 63:461 ( (March) ) 1925. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

INFLUENCE OF THE LIVER ON TOXICITY OF BILE

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1927 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1927.01130190060004
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Abstract

Abstract The fact that bile peritonitis is highly fatal has long been recognized by surgeons. It has been demonstrated repeatedly that bile injected intravenously or intraperitoneally into animals is toxic. The first extensive study of this subject was made by von Dusch1 in 1854. Since that time many valuable contributions have been made, but a great deal of the pathology remains unexplained. Bunting and Brown2 either cut the gallbladder of rabbits and allowed the bile to escape into the peritoneal cavity or injected intraperitoneally from 0.25 to 0.5 cc. of bile per kilogram of body weight. Death occurred in less than twenty-four hours and was attributed to direct action on the myocardium, which revealed degenerative changes. The local pathologic effects which were observed may be summarized in the statement that bile produced necrosis of every type of tissue with which it came in contact. This work was repeated by References 1. Von Dusch, T.: Habilitationschrift, Leipzig, 1854. 2. Bunting, C. H., and Brown, W. H.: The Pathology of Intraperitoneal Bile Injections in the Rabbit , J. Exper. Med. 14:445, 1911.Crossref 3. Frothingham, C., and Minot, G. R.: The Effect of Injection of Bovine Bile into Rabbits , J. M. Research 27:79, 1912. 4. Meltzer, S. J., and Salant, W.: Studies on the Toxicity of Bile , J. Exper. Med. 7:280, 1905.Crossref 5. King, J. H., and Stewart, H. A.: Effect of the Injection of Bile on the Circulation , J. Exper. Med. 11:673, 1909.Crossref 6. King, J. H.; Bigelow, J. E., and Pearce, L.: Experimental Obstructive Jaundice , J. Exper. Med. 14:59, 1911.Crossref 7. Mann, F. C.: Sheard, C.: Bollman, J. L., and Baldes, J.: The Site of the Formation of Bilirubin , Am. J. Physiol. 74:497 ( (Nov.) ) 1925. 8. Rich, A. R.: On the Extrahepatic Formation of Bile Pigment , Bull. Johns Hopkins Hosp. 36:233 ( (April) ) 1925. 9. Buys, E.: Contribution à l'étude de l'action déstructive exercée par le foie sur certains alcaloides , Ann. Soc. Roy. d. sc. méd. et nat. de Bruxelles 4:73, 1895. 10. Cloelta, M.: Ueber das Verhalten des Atropins bei verschieden empfindlichen Tierarten , Arch. f. Exper. Path. u. Pharmkol. supp. vol. 119, 1908. 11. Dixon, W. E., and Lee, W. E.: Tolerance to Nicotine , Quart. J. Exper. Physiol. 5:373, 1912. 12. Edmunds, C. W., and Smith, M. I.: Further Studies in Nicotine Tolerance , J. Lab. & Clin. Med. 1:315, 1915. 13. Weiss, S., and Hatcher, R. A.: Studies on Strychnin , J. Pharmacol. & Exper. Therap. 19:419, 1922. 14. Falls, F. H.: Allergic Phenomena Following Intraportal Injections , J. Infect. Dis. 22:83, 1918. 15. Manwaring, W. H., and Crowe, H. E.: Rôle of Hepatic Tissues in the Acute Anaphylactic Reaction , J. Immunol. 2:517, 1917. 16. McNee, J. W.: Jaundice, a Review of Recent Work , Quart. J. Med. 16:390, 1923. 17. Clark, E. P., and Collip, J. B.: Tisdall Method for Determination of Blood Serum Calcium with a Suggested Modification , J. Biol. Chem. 63:461 ( (March) ) 1925.

Journal

Archives of Surgery – American Medical Association

Published: Jul 1, 1927

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