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Eszopiclone Coadministered With Escitalopram in Patients With Insomnia and Comorbid Generalized Anxiety Disorder

Eszopiclone Coadministered With Escitalopram in Patients With Insomnia and Comorbid Generalized... ORIGINAL ARTICLE Eszopiclone Coadministered With Escitalopram in Patients With Insomnia and Comorbid Generalized Anxiety Disorder Mark Pollack, MD; Gustavo Kinrys, MD; Andrew Krystal, MD; W. Vaughn McCall, MD, MS; Thomas Roth, PhD; Kendyl Schaefer, MS; Robert Rubens, MD, MBA; James Roach, MD; Holly Huang, MS; Ranga Krishnan, MD Context: Insomnia and generalized anxiety disorder ments in total Hamilton Anxiety Scale (HAM-A) scores at (GAD) are prevalent disorders that may coexist. each week (P .05) and at weeks 4 through 10 with the insomnia item removed. Clinical Global Impressions (CGI) Objective: To determine the efficacy of eszopiclone com- of Improvement scores were improved with eszopiclone bined with escitalopram oxalate in treating insomnia co- and escitalopram at every point (P .02), while CGI of Se- morbid with GAD. verity of Illness scores were not significantly different af- ter week 1. The HAM-A response (63% vs 49%, respec- Design: Double-blind, randomized, placebo-controlled, tively, P = .001) and remission (42% vs 36%, respectively, parallel-group, add-on therapy 10-week study. P = .09) rates at week 8 were higher in patients treated with eszopiclone and escitalopram than those treated with pla- Setting: Multicenter outpatient study from July 2005 cebo and escitalopram, and median time to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Eszopiclone Coadministered With Escitalopram in Patients With Insomnia and Comorbid Generalized Anxiety Disorder

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References (53)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archpsyc.65.5.551
pmid
18458207
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Eszopiclone Coadministered With Escitalopram in Patients With Insomnia and Comorbid Generalized Anxiety Disorder Mark Pollack, MD; Gustavo Kinrys, MD; Andrew Krystal, MD; W. Vaughn McCall, MD, MS; Thomas Roth, PhD; Kendyl Schaefer, MS; Robert Rubens, MD, MBA; James Roach, MD; Holly Huang, MS; Ranga Krishnan, MD Context: Insomnia and generalized anxiety disorder ments in total Hamilton Anxiety Scale (HAM-A) scores at (GAD) are prevalent disorders that may coexist. each week (P .05) and at weeks 4 through 10 with the insomnia item removed. Clinical Global Impressions (CGI) Objective: To determine the efficacy of eszopiclone com- of Improvement scores were improved with eszopiclone bined with escitalopram oxalate in treating insomnia co- and escitalopram at every point (P .02), while CGI of Se- morbid with GAD. verity of Illness scores were not significantly different af- ter week 1. The HAM-A response (63% vs 49%, respec- Design: Double-blind, randomized, placebo-controlled, tively, P = .001) and remission (42% vs 36%, respectively, parallel-group, add-on therapy 10-week study. P = .09) rates at week 8 were higher in patients treated with eszopiclone and escitalopram than those treated with pla- Setting: Multicenter outpatient study from July 2005 cebo and escitalopram, and median time to

Journal

JAMA Psychiatry – American Medical Association

Published: May 1, 2008

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