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Neuropsychological Performance in the Unaffected Twin-Reply

Neuropsychological Performance in the Unaffected Twin-Reply Abstract In Reply.— As Dr Green implies, the interpretation of the comparison of unaffected and normal monozygotic twins is complex and open to a number of interpretations. We have examined the issue in more detail in an unpublished manuscript. To summarize our conclusion, it appears that the emotional burden of having an ill cotwin, differences in cooperation and anxiety level, and small differences in parental socioeconomic status might have contributed to the effect sizes that we observed. How- ever, as Dr Green correctly notes, differences were consistently in the predicted direction (unaffected twins performed worse than normal twins). Moreover, they were most marked for those key variables that yielded prominent differences in the contrast between the unaffected and affected groups. This pattern is not inconsistent with the notion that there are cognitive markers for the genetic component of schizophrenia.1-3 In fact, the socioemotional and the cognitive marker viewpoints are not mutually References 1. Neuchterlein KH. Converging evidence for a vigilance deficit as a vulnerability indicator for schizophrenic disorders . In: Alpert M, ed. Controversies in Schizophrenia . New York, NY: Guilford Press; 1986:175-198. 2. Grove WM, Lebow BS, Clementz BA, Cerri A, Medus C, Iacono WG. Family prevalence and coaggregation of schizotypy indicators: a multitrait family study . J Abnorm Psychol . 1991;100:115-121.Crossref 3. Pogue-Geile MF, Garrett AH, Brunke JJ, Hall JK. Neuropsychological impairments are increased in the siblings of schizophrenic patients . Schizophr Res . 1991;4:390.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Neuropsychological Performance in the Unaffected Twin-Reply

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Neuropsychological Performance in the Unaffected Twin-Reply

Abstract

Abstract In Reply.— As Dr Green implies, the interpretation of the comparison of unaffected and normal monozygotic twins is complex and open to a number of interpretations. We have examined the issue in more detail in an unpublished manuscript. To summarize our conclusion, it appears that the emotional burden of having an ill cotwin, differences in cooperation and anxiety level, and small differences in parental socioeconomic status might have contributed to the effect sizes that we...
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1992.01820030079013
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply.— As Dr Green implies, the interpretation of the comparison of unaffected and normal monozygotic twins is complex and open to a number of interpretations. We have examined the issue in more detail in an unpublished manuscript. To summarize our conclusion, it appears that the emotional burden of having an ill cotwin, differences in cooperation and anxiety level, and small differences in parental socioeconomic status might have contributed to the effect sizes that we observed. How- ever, as Dr Green correctly notes, differences were consistently in the predicted direction (unaffected twins performed worse than normal twins). Moreover, they were most marked for those key variables that yielded prominent differences in the contrast between the unaffected and affected groups. This pattern is not inconsistent with the notion that there are cognitive markers for the genetic component of schizophrenia.1-3 In fact, the socioemotional and the cognitive marker viewpoints are not mutually References 1. Neuchterlein KH. Converging evidence for a vigilance deficit as a vulnerability indicator for schizophrenic disorders . In: Alpert M, ed. Controversies in Schizophrenia . New York, NY: Guilford Press; 1986:175-198. 2. Grove WM, Lebow BS, Clementz BA, Cerri A, Medus C, Iacono WG. Family prevalence and coaggregation of schizotypy indicators: a multitrait family study . J Abnorm Psychol . 1991;100:115-121.Crossref 3. Pogue-Geile MF, Garrett AH, Brunke JJ, Hall JK. Neuropsychological impairments are increased in the siblings of schizophrenic patients . Schizophr Res . 1991;4:390.Crossref

Journal

Archives of General Psychiatry – American Medical Association

Published: Mar 1, 1992

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