Effect of Buspirone on Prolactin Secretion Is Not Mediated by 5-HT-1a Receptor Stimulation
Abstract
Abstract To the Editor.— Cocarro et al1 recently reported that pindolol, a serotonin (5-HT-la) antagonist, as well as metergoline, a mixed 5-HT antagonist that also has dopamine agonist properties, inhibited the prolactin (PRL) response to buspirone (0.5 mg/kg administered orally) in two subjects. The inhibitory effect of pindolol was observed at doses of 10 mg and 20 mg in one subject, and at 5 mg and 10 mg in the second subject. In the latter subject, 20 mg of pindolol was reported to...