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Effect of Buspirone on Prolactin Secretion Is Not Mediated by 5-HT-1a Receptor Stimulation

Effect of Buspirone on Prolactin Secretion Is Not Mediated by 5-HT-1a Receptor Stimulation Abstract To the Editor.— Cocarro et al1 recently reported that pindolol, a serotonin (5-HT-la) antagonist, as well as metergoline, a mixed 5-HT antagonist that also has dopamine agonist properties, inhibited the prolactin (PRL) response to buspirone (0.5 mg/kg administered orally) in two subjects. The inhibitory effect of pindolol was observed at doses of 10 mg and 20 mg in one subject, and at 5 mg and 10 mg in the second subject. In the latter subject, 20 mg of pindolol was reported to increase the PRL response to buspirone. Neither pretreatment had any effect on the ability of buspirone to stimulate the growth hormone, corticotropin, or cortisol. On the basis of this, the authors concluded that the buspirone-induced PRL response is likely to be mediated by a 5-HT-l-like receptor.We were the first to report that buspirone increased PRL secretion in man References 1. Coccaro EF, Gabriel S, Mahon T, Macaluso J, Siever LJ. Preliminary evidence of a serotonin (5-HT-1-like) component to the prolactin response to buspirone challenge in humans . Arch Cen Psychiatry . 1990;47:594-595.Crossref 2. Meltzer rÍY, Flemming R, Robertson A. The effect of buspirone on prolactin and growth hormone secretion in man . Arch Cen Psychiatry . 1983;40:1099-1102.Crossref 3. Peroutka SJ. Selective interaction of novel anxiolytics with 5-hydroxytryptamine-1A receptors . Biol Psychiatry . 1985;20:971-979.Crossref 4. 4. Lesch KP, Rupprecht R, Poten B, Müller U, Söhnle K, Fritze J, Schulte HM. Endocrine responses to 5-hydroxytryptamine-1A receptor activation by ipsapirone in humans . Biol Psychiatry . 1989;26:203-205.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Effect of Buspirone on Prolactin Secretion Is Not Mediated by 5-HT-1a Receptor Stimulation

Effect of Buspirone on Prolactin Secretion Is Not Mediated by 5-HT-1a Receptor Stimulation

Abstract

Abstract To the Editor.— Cocarro et al1 recently reported that pindolol, a serotonin (5-HT-la) antagonist, as well as metergoline, a mixed 5-HT antagonist that also has dopamine agonist properties, inhibited the prolactin (PRL) response to buspirone (0.5 mg/kg administered orally) in two subjects. The inhibitory effect of pindolol was observed at doses of 10 mg and 20 mg in one subject, and at 5 mg and 10 mg in the second subject. In the latter subject, 20 mg of pindolol was reported to...
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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1992.01820020083011
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Cocarro et al1 recently reported that pindolol, a serotonin (5-HT-la) antagonist, as well as metergoline, a mixed 5-HT antagonist that also has dopamine agonist properties, inhibited the prolactin (PRL) response to buspirone (0.5 mg/kg administered orally) in two subjects. The inhibitory effect of pindolol was observed at doses of 10 mg and 20 mg in one subject, and at 5 mg and 10 mg in the second subject. In the latter subject, 20 mg of pindolol was reported to increase the PRL response to buspirone. Neither pretreatment had any effect on the ability of buspirone to stimulate the growth hormone, corticotropin, or cortisol. On the basis of this, the authors concluded that the buspirone-induced PRL response is likely to be mediated by a 5-HT-l-like receptor.We were the first to report that buspirone increased PRL secretion in man References 1. Coccaro EF, Gabriel S, Mahon T, Macaluso J, Siever LJ. Preliminary evidence of a serotonin (5-HT-1-like) component to the prolactin response to buspirone challenge in humans . Arch Cen Psychiatry . 1990;47:594-595.Crossref 2. Meltzer rÍY, Flemming R, Robertson A. The effect of buspirone on prolactin and growth hormone secretion in man . Arch Cen Psychiatry . 1983;40:1099-1102.Crossref 3. Peroutka SJ. Selective interaction of novel anxiolytics with 5-hydroxytryptamine-1A receptors . Biol Psychiatry . 1985;20:971-979.Crossref 4. 4. Lesch KP, Rupprecht R, Poten B, Müller U, Söhnle K, Fritze J, Schulte HM. Endocrine responses to 5-hydroxytryptamine-1A receptor activation by ipsapirone in humans . Biol Psychiatry . 1989;26:203-205.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Feb 1, 1992

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