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Nicotine Use as a Possible Risk Factor for Subcortical Abnormalities

Nicotine Use as a Possible Risk Factor for Subcortical Abnormalities Abstract To the Editor.— The findings of Dupont et al1 contribute to the efforts to understand the structural and neuropsy-chological correlates of affective disorder.The authors note that the subcortical signal hyperintensities in the magnetic resonance imaging scans of a subgroup of bipolar patients might also be found in patients with multiple sclerosis or Binswanger's disease. They did not feel that this was relevant in their study because the magnetic resonance imaging abnormalities were not found in similarly screened agematched controls. While these patients were screened for alcohol and drug abuse, no mention was made of nicotine use. Roman2 reviewed the white matter lesions in dementia of the Binswanger type and noted that smoking may be one of the risk factors leading to diminished blood flow in susceptible subcortical regions. If there was a differential use of nicotine between subjects with positive or negative scans in the References 1. Dupont RM, Jernigan TL, Butters N, Delis D, Hesselink JR, Heindel W, Gillin JC. Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging: clinical and neuropsychological significance . Arch Gen Psychiatry . 1990;47:55-59.Crossref 2. Roman GC. Senile dementia of the Binswanger type: a vascular form of dementia in the elderly . JAMA . 1987;257:1782-1788.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Nicotine Use as a Possible Risk Factor for Subcortical Abnormalities

Archives of General Psychiatry , Volume 47 (12) – Dec 1, 1990

Nicotine Use as a Possible Risk Factor for Subcortical Abnormalities

Abstract

Abstract To the Editor.— The findings of Dupont et al1 contribute to the efforts to understand the structural and neuropsy-chological correlates of affective disorder.The authors note that the subcortical signal hyperintensities in the magnetic resonance imaging scans of a subgroup of bipolar patients might also be found in patients with multiple sclerosis or Binswanger's disease. They did not feel that this was relevant in their study because the magnetic resonance imaging...
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1990.01810240092015
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The findings of Dupont et al1 contribute to the efforts to understand the structural and neuropsy-chological correlates of affective disorder.The authors note that the subcortical signal hyperintensities in the magnetic resonance imaging scans of a subgroup of bipolar patients might also be found in patients with multiple sclerosis or Binswanger's disease. They did not feel that this was relevant in their study because the magnetic resonance imaging abnormalities were not found in similarly screened agematched controls. While these patients were screened for alcohol and drug abuse, no mention was made of nicotine use. Roman2 reviewed the white matter lesions in dementia of the Binswanger type and noted that smoking may be one of the risk factors leading to diminished blood flow in susceptible subcortical regions. If there was a differential use of nicotine between subjects with positive or negative scans in the References 1. Dupont RM, Jernigan TL, Butters N, Delis D, Hesselink JR, Heindel W, Gillin JC. Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging: clinical and neuropsychological significance . Arch Gen Psychiatry . 1990;47:55-59.Crossref 2. Roman GC. Senile dementia of the Binswanger type: a vascular form of dementia in the elderly . JAMA . 1987;257:1782-1788.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Dec 1, 1990

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