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Efficacy of Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders Questioned

Efficacy of Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders Questioned Abstract To the Editor.— I would like to comment on two articles in the Archives.1,2 These two articles from some of the world's most famous and reputable universities must be received by European psychiatrists with the utmost attention.The article by Lipman et al1 deals with a sample of primarily depressed outpatients (recruited by advertisement), who are not very ill but considered to be at least moderately depressed. The mean score on the Hamilton Depression Scale (on 21-item modification) was 22.1±6, telling us that a part of the sample hardly meets Hamilton's criteria for clinical depression (>15 on a 17-item scale). This is unjust to the outcome of treatment, probably more so to treatment with imipramine hydrochloride than to the other treatments, and might explain why patients at week 8 did not rate appreciable improvement very often; only 31% rated "very much better" or "quite a bit better." That References 1. Lipman RS, Covi L, Rickels K, McNair DM, Downing R, Kahn RJ, Lasseter VK, Faden V: Imipramine and chlordiazepoxide in depressive and anxiety disorders: I. Efficacy in depressed outpatients . Arch Gen Psychiatry 1986;43:68-77.Crossref 2. Kahn RJ, McNair DM, Lipman RS, Covi L, Rickels K, Downing R, Fisher S, Frankenthaler LM: Imipramine and chlordiazepoxide in depressive and anxiety disorders: II. Efficacy in anxious outpatients . Arch Gen Psychiatry 1986;43:79-85.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Efficacy of Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders Questioned

Archives of General Psychiatry , Volume 44 (1) – Jan 1, 1987

Efficacy of Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders Questioned

Abstract

Abstract To the Editor.— I would like to comment on two articles in the Archives.1,2 These two articles from some of the world's most famous and reputable universities must be received by European psychiatrists with the utmost attention.The article by Lipman et al1 deals with a sample of primarily depressed outpatients (recruited by advertisement), who are not very ill but considered to be at least moderately depressed. The mean score on the Hamilton Depression Scale (on 21-item...
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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1987.01800130109021
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— I would like to comment on two articles in the Archives.1,2 These two articles from some of the world's most famous and reputable universities must be received by European psychiatrists with the utmost attention.The article by Lipman et al1 deals with a sample of primarily depressed outpatients (recruited by advertisement), who are not very ill but considered to be at least moderately depressed. The mean score on the Hamilton Depression Scale (on 21-item modification) was 22.1±6, telling us that a part of the sample hardly meets Hamilton's criteria for clinical depression (>15 on a 17-item scale). This is unjust to the outcome of treatment, probably more so to treatment with imipramine hydrochloride than to the other treatments, and might explain why patients at week 8 did not rate appreciable improvement very often; only 31% rated "very much better" or "quite a bit better." That References 1. Lipman RS, Covi L, Rickels K, McNair DM, Downing R, Kahn RJ, Lasseter VK, Faden V: Imipramine and chlordiazepoxide in depressive and anxiety disorders: I. Efficacy in depressed outpatients . Arch Gen Psychiatry 1986;43:68-77.Crossref 2. Kahn RJ, McNair DM, Lipman RS, Covi L, Rickels K, Downing R, Fisher S, Frankenthaler LM: Imipramine and chlordiazepoxide in depressive and anxiety disorders: II. Efficacy in anxious outpatients . Arch Gen Psychiatry 1986;43:79-85.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Jan 1, 1987

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