Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Immunological Distubances in Psychiatric Patients

Immunological Distubances in Psychiatric Patients Abstract To the Editor.— In their article on immunological disturbances in psychiatric patients, Roos et al1 found no changes in immunoglobulin levels in schizophrenics and depressed patients, which suggested to them that viral and autoimmune factors were not of etiological significance in these conditions.Eighty-two percent of the sample population in this study was composed of schizophrenic patients who had been exposed to neuroleptics for prolonged periods of time. Gowdy2 has shown that neuroleptics affect immunoglobulin levels. Furthermore, although these patients had been drug-free for two weeks before specimens were obtained, active metabolites of these drugs can still be present in the tissues for up to 60 days or longer.3,4 What effect this would have on immunological criteria is uncertain.To avoid this problematic effect, the sample population should ideally be composed only of patients who have never taken neuroleptics. References 1. Roos RP, Davis K, Meltzer HY: Immunoglobulin studies in patients with psychiatric diseases . Arch Gen Psychiatry 1985;42:124-128.Crossref 2. Gowdy JM: Immunoglobulin levels in psychotic patients . Psychosomatics 1980;21:751-756.Crossref 3. Baldessarini RJ: Antipsychotic Agents in Chemotherapy in Psychiatry . Cambridge, Mass, Harvard University Press, 1977. 4. Curry SH: Metabolism and kinetics of chlorpromazine in relation to effect , in Sedvall G, Uvnes B, Zotterman V (eds): Antipsychotic Drugs: Pharmacodynamics and Pharmacokinetics . Oxford, England, Pergamon Press, 1976, pp 343-352. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Immunological Distubances in Psychiatric Patients

Download PDF
1 page

Immunological Distubances in Psychiatric Patients

Abstract

Abstract To the Editor.— In their article on immunological disturbances in psychiatric patients, Roos et al1 found no changes in immunoglobulin levels in schizophrenics and depressed patients, which suggested to them that viral and autoimmune factors were not of etiological significance in these conditions.Eighty-two percent of the sample population in this study was composed of schizophrenic patients who had been exposed to neuroleptics for prolonged periods of time. Gowdy2 has shown...
Loading next page...
 
/lp/american-medical-association/immunological-distubances-in-psychiatric-patients-aQ2szNYRQd

References (4)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1986.01800020100016
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— In their article on immunological disturbances in psychiatric patients, Roos et al1 found no changes in immunoglobulin levels in schizophrenics and depressed patients, which suggested to them that viral and autoimmune factors were not of etiological significance in these conditions.Eighty-two percent of the sample population in this study was composed of schizophrenic patients who had been exposed to neuroleptics for prolonged periods of time. Gowdy2 has shown that neuroleptics affect immunoglobulin levels. Furthermore, although these patients had been drug-free for two weeks before specimens were obtained, active metabolites of these drugs can still be present in the tissues for up to 60 days or longer.3,4 What effect this would have on immunological criteria is uncertain.To avoid this problematic effect, the sample population should ideally be composed only of patients who have never taken neuroleptics. References 1. Roos RP, Davis K, Meltzer HY: Immunoglobulin studies in patients with psychiatric diseases . Arch Gen Psychiatry 1985;42:124-128.Crossref 2. Gowdy JM: Immunoglobulin levels in psychotic patients . Psychosomatics 1980;21:751-756.Crossref 3. Baldessarini RJ: Antipsychotic Agents in Chemotherapy in Psychiatry . Cambridge, Mass, Harvard University Press, 1977. 4. Curry SH: Metabolism and kinetics of chlorpromazine in relation to effect , in Sedvall G, Uvnes B, Zotterman V (eds): Antipsychotic Drugs: Pharmacodynamics and Pharmacokinetics . Oxford, England, Pergamon Press, 1976, pp 343-352.

Journal

Archives of General Psychiatry – American Medical Association

Published: Feb 1, 1986

There are no references for this article.