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Cerebral Ventricular Enlargement in Schizophrenia: A Preliminary Follow-up Study

Cerebral Ventricular Enlargement in Schizophrenia: A Preliminary Follow-up Study Abstract • Lateral cerebral ventricular enlargement is now known to occur in some schizophrenic patients. To determine whether ventriculomegaly in schizophrenia is a static vs progressive process, we conducted a follow-up computed tomographic brain scan study on 11 young male patients, three years after initial scans were obtained. No significant change was found in the mean ventricles-brain ratio of this small schizophrenic sample after three years. Four of 11 patients showed noticeable increases (>50%) in individual ratio. Methodologic problems are discussed and the need for follow-up studies as a research strategy is emphasized. References 1. Weinberger DR, Wagner RL, Wyatt RJ: Neuropathological studies of schizophrenia: A selective review . Schizophr Bull 1983;9:193-212.Crossref 2. Nasrallah HA, Coffman JA: Computerized tomography in psychiatry: An overview . Psychiatr Ann 1985;15:239-249.Crossref 3. Weinberger DR, Wyatt RJ: Brain morphology in schizophrenia: In vivo studies , in Henn FA, Nasrallah HA (eds): Schizophrenia as a Brain Disease . New York, Oxford University Press, 1982, pp 148-175. 4. Pearlson GD, Veroff AE: Computerized tomographic scan changes in manic depressive illness . Lancet 1981;2:470.Crossref 5. Nasrallah HA, McCalley-Whitters M, Jacoby CG: Cerebral ventricular enlargement in young manic males: A controlled CT study . J Affective Dis 1982;4:15-19.Crossref 6. Jernigan TL, Zatz LM, Moses JA, Berger PA: Computed tomography in schizophrenics and normal volunteers . Arch Gen Psychiatry 1982;39:765-770.Crossref 7. Weinberger DR, Torrey EF, Wyatt RJ: Cerebellar atrophy in chronic schizophrenia . Lancet 1979;1:718-719.Crossref 8. Lempke R: Untersuchungen über die soziale Prognose der schizophrenic unter besonderer Berucksichtigung des encephalographischen Befundes . Arch Psychiatry Nervenkr 1935;104:89-136.Crossref 9. Jacobi W, Winkler H: Encephalographische studien au chronisch schizophrenen . Arch Psychiatry Nervenkr 1927;81:299-332.Crossref 10. Haug JO: Pneumoencephalographic studies in mental disease . Acta Psychiatr Scand 1962;38( (suppl 165) ):1-114.Crossref 11. LeMay M: Changes in ventricular size during and after pneumoencephalography . Radiology 1967;88:57-63.Crossref 12. Nasrallah HA, Kuperman S, Hamra BJ, McCalley-Whitters M: Clinical differences between schizophrenic patients with and without large cerebral ventricles . J Clin Psychiatry 1983;44:407-409. 13. Zatz LM, Jernigan TL, Ahumada AJ: Changes on computed cranial tomography with aging: Intracranial fluid volume . AJNR 1982;3:1-11. 14. Nasrallah HA, Jacoby CG, McCalley-Whitters M, Kuperman S: Cerebral ventricular enlargement in subtypes of chronic schizophrenia . Arch Gen Psychiatry 1982;39:774-777.Crossref 15. Synek V, Reuben JR: The ventricular-brain ratio using planimetric measurement of EMI scans . Br J Radiol 1976;49:233-237.Crossref 16. Weinberger DR, DeLisi LE, Perman S, Targum S, Wyatt RJ: Computed tomography in schizophreniform disorder and other acute psychiatric disorders . Arch Gen Psychiatry 1982;39:778-783.Crossref 17. Woods BT, Wolf J: A reconsideration of the relation of ventricular enlargement to duration of illness in schizophrenia . Am J Psychiatry 1983;140:1564-1570. 18. Cala LA, Mastaglia FL: Computerized tomography in chronic alcoholics . Alcohol Clin Exp Res 1981;5:283-294.Crossref 19. Deonna T, Voumard C: Reversible cerebral atrophy and corticotrophin . Lancet 1979;2:207.Crossref 20. Smith RC, Calderon M, Ravichandran GK, Largen J, Vroulis G, Shvartsburd A, Gordon J, Schoolar JC: Nuclear magnetic resonance in schizophrenia: A preliminary study . Psychiatry Res 1984;12:137-147.Crossref 21. Nasrallah HA, Andreasen NC, Olson SC: Magnetic resonance brain imaging studies in schizophrenia. Read before the annual meeting of the Society for Magnetic Resonance Imaging, San Diego, March 23, 1985. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Cerebral Ventricular Enlargement in Schizophrenia: A Preliminary Follow-up Study

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1986.01800020067008
Publisher site
See Article on Publisher Site

Abstract

Abstract • Lateral cerebral ventricular enlargement is now known to occur in some schizophrenic patients. To determine whether ventriculomegaly in schizophrenia is a static vs progressive process, we conducted a follow-up computed tomographic brain scan study on 11 young male patients, three years after initial scans were obtained. No significant change was found in the mean ventricles-brain ratio of this small schizophrenic sample after three years. Four of 11 patients showed noticeable increases (>50%) in individual ratio. Methodologic problems are discussed and the need for follow-up studies as a research strategy is emphasized. References 1. Weinberger DR, Wagner RL, Wyatt RJ: Neuropathological studies of schizophrenia: A selective review . Schizophr Bull 1983;9:193-212.Crossref 2. Nasrallah HA, Coffman JA: Computerized tomography in psychiatry: An overview . Psychiatr Ann 1985;15:239-249.Crossref 3. Weinberger DR, Wyatt RJ: Brain morphology in schizophrenia: In vivo studies , in Henn FA, Nasrallah HA (eds): Schizophrenia as a Brain Disease . New York, Oxford University Press, 1982, pp 148-175. 4. Pearlson GD, Veroff AE: Computerized tomographic scan changes in manic depressive illness . Lancet 1981;2:470.Crossref 5. Nasrallah HA, McCalley-Whitters M, Jacoby CG: Cerebral ventricular enlargement in young manic males: A controlled CT study . J Affective Dis 1982;4:15-19.Crossref 6. Jernigan TL, Zatz LM, Moses JA, Berger PA: Computed tomography in schizophrenics and normal volunteers . Arch Gen Psychiatry 1982;39:765-770.Crossref 7. Weinberger DR, Torrey EF, Wyatt RJ: Cerebellar atrophy in chronic schizophrenia . Lancet 1979;1:718-719.Crossref 8. Lempke R: Untersuchungen über die soziale Prognose der schizophrenic unter besonderer Berucksichtigung des encephalographischen Befundes . Arch Psychiatry Nervenkr 1935;104:89-136.Crossref 9. Jacobi W, Winkler H: Encephalographische studien au chronisch schizophrenen . Arch Psychiatry Nervenkr 1927;81:299-332.Crossref 10. Haug JO: Pneumoencephalographic studies in mental disease . Acta Psychiatr Scand 1962;38( (suppl 165) ):1-114.Crossref 11. LeMay M: Changes in ventricular size during and after pneumoencephalography . Radiology 1967;88:57-63.Crossref 12. Nasrallah HA, Kuperman S, Hamra BJ, McCalley-Whitters M: Clinical differences between schizophrenic patients with and without large cerebral ventricles . J Clin Psychiatry 1983;44:407-409. 13. Zatz LM, Jernigan TL, Ahumada AJ: Changes on computed cranial tomography with aging: Intracranial fluid volume . AJNR 1982;3:1-11. 14. Nasrallah HA, Jacoby CG, McCalley-Whitters M, Kuperman S: Cerebral ventricular enlargement in subtypes of chronic schizophrenia . Arch Gen Psychiatry 1982;39:774-777.Crossref 15. Synek V, Reuben JR: The ventricular-brain ratio using planimetric measurement of EMI scans . Br J Radiol 1976;49:233-237.Crossref 16. Weinberger DR, DeLisi LE, Perman S, Targum S, Wyatt RJ: Computed tomography in schizophreniform disorder and other acute psychiatric disorders . Arch Gen Psychiatry 1982;39:778-783.Crossref 17. Woods BT, Wolf J: A reconsideration of the relation of ventricular enlargement to duration of illness in schizophrenia . Am J Psychiatry 1983;140:1564-1570. 18. Cala LA, Mastaglia FL: Computerized tomography in chronic alcoholics . Alcohol Clin Exp Res 1981;5:283-294.Crossref 19. Deonna T, Voumard C: Reversible cerebral atrophy and corticotrophin . Lancet 1979;2:207.Crossref 20. Smith RC, Calderon M, Ravichandran GK, Largen J, Vroulis G, Shvartsburd A, Gordon J, Schoolar JC: Nuclear magnetic resonance in schizophrenia: A preliminary study . Psychiatry Res 1984;12:137-147.Crossref 21. Nasrallah HA, Andreasen NC, Olson SC: Magnetic resonance brain imaging studies in schizophrenia. Read before the annual meeting of the Society for Magnetic Resonance Imaging, San Diego, March 23, 1985.

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Feb 1, 1986

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