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Depressive Disease: Evidence Favoring Polygenic Inheritance Based on an Analysis of Ancestral Cases

Depressive Disease: Evidence Favoring Polygenic Inheritance Based on an Analysis of Ancestral Cases Abstract The possible mode of genetic transmission of depressive disease (primary unipolar affective disorder) was studied using a computationa model for the analysis of inheritance patterns devised by Slater. Detailed analyses of the occurrence of certain psychiatric disorders (depressive disease, alcoholism, and sociopathy) among secondary relatives of rigorously defined depressive probands were conducted for the probands as a group, as well as for subgroups based on age of onset, sex, and the types of psychiatric illnesses found in their families. Independent observations have suggested that genetic factors may be involved in the etiology of depressive disease. If genetic factors are involved, these data suggest that polygenic, rather than dominant gene, transmission, is the most likely possibility for both the entire proband group and for the various subdivisions. References 1. Leonhard K: Aufteilung der endogenen Psychosen , ed 2. Berlin, Akademie Verlag, 1959. 2. Angst J: Zur Ätiologie und Nosologie endogener depressiver Psychosen . Monogr Neurol Psychiat 112:1-118, 1966. 3. Perris C (ed): A study of bipolar (manic depressive) and unipolar recurrent depressive psychoses . Acta Psychiat Scand 42( (suppl 194) ):1-189, 1966.Crossref 4. Zerbin-Rüdin E: Zur Genetik der depressiven Erkrankungen. Vortrag auf der Intern . Arbeitstagung über das depressive Syndrom , Berlin, 1968. 5. Winokur G, Clayton P: Family history studies: I. Two types of affective disorders separated according to genetic and clinical factors . Recent Advances Biol Psychiat 9:35-50, 1967. 6. Cadoret R, Winokur G, Clayton P: Family history studies: VII. Manic depressive disease versus depressive disease . Brit J Psychiat 116:625-635, 1970.Crossref 7. Perris C: Abnormality on paternal and maternal sides: Observations in bipolar (manic depressive) and unipolar depressive psychoses . Brit J Psychiat 118:207-210, 1971.Crossref 8. Perris C: Genetic transmission of depressive psychoses . Acta Psychiat Scand 44( (suppl 203) ):45-52, 1968.Crossref 9. Baker M, Dorzab J, Winokur G, et al: Depressive disease: The effect of the postpartum state . Biol Psychiat 3:357-365, 1971. 10. Beigel A, Murphy DL: Unipolar and bipolar affective illness: Differences in clinical characteristics accompanying depression . Arch Gen Psychiat 24:215-220, 1971.Crossref 11. Rowe C, Daggett D: Prepsychotic personality traits in manic-depressive disease . J Nerv Ment Dis 119:412-420, 1954.Crossref 12. Leonhard K: Die präpsychotischen Temperamente bei der monopolaren und bipolaren phasischen Psychosen . Psychiat Neurol 46:105-115, 1963.Crossref 13. Murphy DL, Brodie HKH, Goodwin FK, et al: Regular induction of hypomania by L-DOPA in "bipolar" manic-depressive patients . Nature 229:135-136, 1971.Crossref 14. Goodwin FK, Murphy DL, Bunney WE Jr: Behavioral-biochemical studies of lithium treatment . Sci Proc Amer Psychiat Assoc 124:233, 1968. 15. Goodwin FK, Murphy DL, Dunner DL, et al: Lithium response in unipolar vs bipolar depression . Amer J Psychiat , to be published. 16. Buchsbaum M, Goodwin F, Murphy D, et al: AER in affective disorders . Amer J Psychiat 128:19-25, 1971. 17. Dunner DL, Cohn CK, Gershon ES, et al: Differential catechol-O-methyl transferase activity in unipolar and bipolar affective illness . Arch Gen Psychiat 25:348-353, 1971.Crossref 18. Dunner DL, Goodwin FK, Gershon ES, et al: Excretion of 17-OHCS in unipolar and bipolar depressed patients . Arch Gen Psychiat 26:360-363, 1972.Crossref 19. Murphy DL, Weiss R: Monoamine oxidase: Reduced activity in blood platelets from bipolar depressed patients. To be published. 20. Winokur G, Cadoret R, Dorzab J, et al: Depressive disease: A genetic study . Arch Gen Psychiat 24:135-144, 1971.Crossref 21. Robins E, Guze SB: Classification of affective disorders: The primary-secondary, the endogenous-reactive, and the neurotic-psychotic concepts, in Recent Advances in the Psychobiology of the Depressive Illnesses: Proceedings of a workshop sponsored by NIMH. Government Printing Office, to be published. 22. Baker M, Dorzab J, Winokur G, et al: Depressive disease: Classification and clinical characteristics . Compr Psychiat 12:354-365, 1971.Crossref 23. Dorzab J, Baker M, Winokur G, et al: Depressive disease: Clinical course . Dis Nerv Syst 32:269-274, 1971. 24. Cadoret RJ, Baker M, Dorzab J, et al: Depressive disease: Personality factors in patients and their relatives . Biol Psychiat 3:85-93, 1971. 25. Cadoret RJ, Winokur G, Dorzab J, et al: Depressive disease: Life events and onset of illness . Arch Gen Psychiat 26:133-136, 1972.Crossref 26. Slater E: Expectation of abnormality on paternal and maternal sides: A computational model . J Med Genet 3:159-161, 1966.Crossref 27. Guze SB, Goodwin DW, Crane JB: Criminality and psychiatric disorders . Arch Gen Psychiat 20:583-591, 1969.Crossref 28. Robins L: Deviant Children Grown-Up . Baltimore, Williams & Wilkins Co, 1966. 29. Rimmer J, Chambers DS: Alcoholism: Methodological considerations in the study of family illness . Amer J Orthopsychiat 39:760-768, 1969.Crossref 30. Dorzab J, Baker M, Cadoret R, et al: Depressive disease: Familial psychiatric illness . Amer J Psychiat 127:1128-1133, 1971. 31. Slater E, Maxwell J, Price JS: Distributions of ancestral secondary cases in bipolar affective disorders . Brit J Psychiat 118:215-218, 1971.Crossref 32. Woodruff RA Jr, Guze SB, Clayton PB: Unipolar and bipolar affective disorder . Brit J Psychiat 119:33-38, 1971.Crossref 33. Winokur G, Clayton PJ, Reich T: Manic-Depressive Illness . St. Louis, CV Mosby Co, 1969. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Depressive Disease: Evidence Favoring Polygenic Inheritance Based on an Analysis of Ancestral Cases

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References (34)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1972.01750270030004
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Abstract

Abstract The possible mode of genetic transmission of depressive disease (primary unipolar affective disorder) was studied using a computationa model for the analysis of inheritance patterns devised by Slater. Detailed analyses of the occurrence of certain psychiatric disorders (depressive disease, alcoholism, and sociopathy) among secondary relatives of rigorously defined depressive probands were conducted for the probands as a group, as well as for subgroups based on age of onset, sex, and the types of psychiatric illnesses found in their families. Independent observations have suggested that genetic factors may be involved in the etiology of depressive disease. If genetic factors are involved, these data suggest that polygenic, rather than dominant gene, transmission, is the most likely possibility for both the entire proband group and for the various subdivisions. References 1. Leonhard K: Aufteilung der endogenen Psychosen , ed 2. Berlin, Akademie Verlag, 1959. 2. Angst J: Zur Ätiologie und Nosologie endogener depressiver Psychosen . Monogr Neurol Psychiat 112:1-118, 1966. 3. Perris C (ed): A study of bipolar (manic depressive) and unipolar recurrent depressive psychoses . Acta Psychiat Scand 42( (suppl 194) ):1-189, 1966.Crossref 4. Zerbin-Rüdin E: Zur Genetik der depressiven Erkrankungen. Vortrag auf der Intern . Arbeitstagung über das depressive Syndrom , Berlin, 1968. 5. Winokur G, Clayton P: Family history studies: I. Two types of affective disorders separated according to genetic and clinical factors . Recent Advances Biol Psychiat 9:35-50, 1967. 6. Cadoret R, Winokur G, Clayton P: Family history studies: VII. Manic depressive disease versus depressive disease . Brit J Psychiat 116:625-635, 1970.Crossref 7. Perris C: Abnormality on paternal and maternal sides: Observations in bipolar (manic depressive) and unipolar depressive psychoses . Brit J Psychiat 118:207-210, 1971.Crossref 8. Perris C: Genetic transmission of depressive psychoses . Acta Psychiat Scand 44( (suppl 203) ):45-52, 1968.Crossref 9. Baker M, Dorzab J, Winokur G, et al: Depressive disease: The effect of the postpartum state . Biol Psychiat 3:357-365, 1971. 10. Beigel A, Murphy DL: Unipolar and bipolar affective illness: Differences in clinical characteristics accompanying depression . Arch Gen Psychiat 24:215-220, 1971.Crossref 11. Rowe C, Daggett D: Prepsychotic personality traits in manic-depressive disease . J Nerv Ment Dis 119:412-420, 1954.Crossref 12. Leonhard K: Die präpsychotischen Temperamente bei der monopolaren und bipolaren phasischen Psychosen . Psychiat Neurol 46:105-115, 1963.Crossref 13. Murphy DL, Brodie HKH, Goodwin FK, et al: Regular induction of hypomania by L-DOPA in "bipolar" manic-depressive patients . Nature 229:135-136, 1971.Crossref 14. Goodwin FK, Murphy DL, Bunney WE Jr: Behavioral-biochemical studies of lithium treatment . Sci Proc Amer Psychiat Assoc 124:233, 1968. 15. Goodwin FK, Murphy DL, Dunner DL, et al: Lithium response in unipolar vs bipolar depression . Amer J Psychiat , to be published. 16. Buchsbaum M, Goodwin F, Murphy D, et al: AER in affective disorders . Amer J Psychiat 128:19-25, 1971. 17. Dunner DL, Cohn CK, Gershon ES, et al: Differential catechol-O-methyl transferase activity in unipolar and bipolar affective illness . Arch Gen Psychiat 25:348-353, 1971.Crossref 18. Dunner DL, Goodwin FK, Gershon ES, et al: Excretion of 17-OHCS in unipolar and bipolar depressed patients . Arch Gen Psychiat 26:360-363, 1972.Crossref 19. Murphy DL, Weiss R: Monoamine oxidase: Reduced activity in blood platelets from bipolar depressed patients. To be published. 20. Winokur G, Cadoret R, Dorzab J, et al: Depressive disease: A genetic study . Arch Gen Psychiat 24:135-144, 1971.Crossref 21. Robins E, Guze SB: Classification of affective disorders: The primary-secondary, the endogenous-reactive, and the neurotic-psychotic concepts, in Recent Advances in the Psychobiology of the Depressive Illnesses: Proceedings of a workshop sponsored by NIMH. Government Printing Office, to be published. 22. Baker M, Dorzab J, Winokur G, et al: Depressive disease: Classification and clinical characteristics . Compr Psychiat 12:354-365, 1971.Crossref 23. Dorzab J, Baker M, Winokur G, et al: Depressive disease: Clinical course . Dis Nerv Syst 32:269-274, 1971. 24. Cadoret RJ, Baker M, Dorzab J, et al: Depressive disease: Personality factors in patients and their relatives . Biol Psychiat 3:85-93, 1971. 25. Cadoret RJ, Winokur G, Dorzab J, et al: Depressive disease: Life events and onset of illness . Arch Gen Psychiat 26:133-136, 1972.Crossref 26. Slater E: Expectation of abnormality on paternal and maternal sides: A computational model . J Med Genet 3:159-161, 1966.Crossref 27. Guze SB, Goodwin DW, Crane JB: Criminality and psychiatric disorders . Arch Gen Psychiat 20:583-591, 1969.Crossref 28. Robins L: Deviant Children Grown-Up . Baltimore, Williams & Wilkins Co, 1966. 29. Rimmer J, Chambers DS: Alcoholism: Methodological considerations in the study of family illness . Amer J Orthopsychiat 39:760-768, 1969.Crossref 30. Dorzab J, Baker M, Cadoret R, et al: Depressive disease: Familial psychiatric illness . Amer J Psychiat 127:1128-1133, 1971. 31. Slater E, Maxwell J, Price JS: Distributions of ancestral secondary cases in bipolar affective disorders . Brit J Psychiat 118:215-218, 1971.Crossref 32. Woodruff RA Jr, Guze SB, Clayton PB: Unipolar and bipolar affective disorder . Brit J Psychiat 119:33-38, 1971.Crossref 33. Winokur G, Clayton PJ, Reich T: Manic-Depressive Illness . St. Louis, CV Mosby Co, 1969.

Journal

Archives of General Psychiatry – American Medical Association

Published: Sep 1, 1972

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