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Intranasal Midazolam vs Rectal Diazepam for the Home Treatment of Acute Seizures in Pediatric Patients With Epilepsy

Intranasal Midazolam vs Rectal Diazepam for the Home Treatment of Acute Seizures in Pediatric... ARTICLE JOURNAL CLUB Intranasal Midazolam vs Rectal Diazepam for the Home Treatment of Acute Seizures in Pediatric Patients With Epilepsy Maija Holsti, MD, MPH; Nanette Dudley, MD; Jeff Schunk, MD; Kathleen Adelgais, MD, MPH; Richard Greenberg, MD; Cody Olsen, MS; Aaron Healy, BS; Sean Firth, PhD, MPH; Francis Filloux, MD Objective: To compare intranasal midazolam, using a department visits, hospitalizations, and caretakers’ ease Mucosal Atomization Device (IN-MMAD), with rectal di- of administration and satisfaction with the medication. azepam (RD) for the home treatment of seizures in chil- dren with epilepsy. Results: A total of 92 caretakers gave the study medi- cation during a child’s seizure (50 IN-MMAD, 42 RD). Design: Prospective randomized study. The median time from medication administration to sei- zure cessation for IN-MMAD was 1.3 minutes less than Setting: Patients’ homes and a freestanding children’s for RD (95% confidence interval, 0.0-3.5 minutes; P = .09). hospital that serves as a referral center for 5 states. The median time to medication administration was 5.0 minutes for each group. No differences in complica- Patients: A total of 358 pediatric patients who visited a tions were found between treatment groups. Caretakers pediatric neurology clinic from July 2006 through Sep- were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Intranasal Midazolam vs Rectal Diazepam for the Home Treatment of Acute Seizures in Pediatric Patients With Epilepsy

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References (49)

Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2010.130
pmid
20679166
Publisher site
See Article on Publisher Site

Abstract

ARTICLE JOURNAL CLUB Intranasal Midazolam vs Rectal Diazepam for the Home Treatment of Acute Seizures in Pediatric Patients With Epilepsy Maija Holsti, MD, MPH; Nanette Dudley, MD; Jeff Schunk, MD; Kathleen Adelgais, MD, MPH; Richard Greenberg, MD; Cody Olsen, MS; Aaron Healy, BS; Sean Firth, PhD, MPH; Francis Filloux, MD Objective: To compare intranasal midazolam, using a department visits, hospitalizations, and caretakers’ ease Mucosal Atomization Device (IN-MMAD), with rectal di- of administration and satisfaction with the medication. azepam (RD) for the home treatment of seizures in chil- dren with epilepsy. Results: A total of 92 caretakers gave the study medi- cation during a child’s seizure (50 IN-MMAD, 42 RD). Design: Prospective randomized study. The median time from medication administration to sei- zure cessation for IN-MMAD was 1.3 minutes less than Setting: Patients’ homes and a freestanding children’s for RD (95% confidence interval, 0.0-3.5 minutes; P = .09). hospital that serves as a referral center for 5 states. The median time to medication administration was 5.0 minutes for each group. No differences in complica- Patients: A total of 358 pediatric patients who visited a tions were found between treatment groups. Caretakers pediatric neurology clinic from July 2006 through Sep- were

Journal

JAMA PediatricsAmerican Medical Association

Published: Aug 1, 2010

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