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ARTICLE JOURNAL CLUB Intranasal Midazolam vs Rectal Diazepam for the Home Treatment of Acute Seizures in Pediatric Patients With Epilepsy Maija Holsti, MD, MPH; Nanette Dudley, MD; Jeff Schunk, MD; Kathleen Adelgais, MD, MPH; Richard Greenberg, MD; Cody Olsen, MS; Aaron Healy, BS; Sean Firth, PhD, MPH; Francis Filloux, MD Objective: To compare intranasal midazolam, using a department visits, hospitalizations, and caretakers’ ease Mucosal Atomization Device (IN-MMAD), with rectal di- of administration and satisfaction with the medication. azepam (RD) for the home treatment of seizures in chil- dren with epilepsy. Results: A total of 92 caretakers gave the study medi- cation during a child’s seizure (50 IN-MMAD, 42 RD). Design: Prospective randomized study. The median time from medication administration to sei- zure cessation for IN-MMAD was 1.3 minutes less than Setting: Patients’ homes and a freestanding children’s for RD (95% confidence interval, 0.0-3.5 minutes; P = .09). hospital that serves as a referral center for 5 states. The median time to medication administration was 5.0 minutes for each group. No differences in complica- Patients: A total of 358 pediatric patients who visited a tions were found between treatment groups. Caretakers pediatric neurology clinic from July 2006 through Sep- were
JAMA Pediatrics – American Medical Association
Published: Aug 1, 2010
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