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Effects of Unilateral Clefts on Brain Structure

Effects of Unilateral Clefts on Brain Structure ARTICLE Ellen van der Plas, MPhil; Amy Conrad, PhD; John Canady, MD; Lynn Richman, PhD; Peg Nopoulos, MD Objective: To evaluate potential abnormalities in brain Results: Total white matter was significantly lower in structure of children and adolescents with unilateral clefts. boys with right clefts compared with boys with left clefts and healthy boys. Gross regional analyses demon- Design: Case-control study. strated that reductions in white matter were evident in both the cerebellum and the cerebrum in boys with right Setting: Tertiary care center. clefts. Furthermore, within the cerebrum, white matter volumes were particularly low in the frontal lobes and Participants: Boys aged 7 to 17 years with right (n=14) the occipital lobes. and left (n=19) clefts were compared with healthy age- matched boys (n=57). Conclusions: These preliminary results suggest that right clefts may be associated with more abnormalities Main Exposures: Structural brain measures were ob- in brain structure. More generally, laterality of a birth tained using magnetic resonance imaging. defect may have a significant effect on a developing organism. Outcome Measure: It was explored whether lateral- ity of clefts had a significant effect on brain structure. To this end, volumes of tissue types and various brain re- gions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Effects of Unilateral Clefts on Brain Structure

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References (43)

Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2010.123
pmid
20679168
Publisher site
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Abstract

ARTICLE Ellen van der Plas, MPhil; Amy Conrad, PhD; John Canady, MD; Lynn Richman, PhD; Peg Nopoulos, MD Objective: To evaluate potential abnormalities in brain Results: Total white matter was significantly lower in structure of children and adolescents with unilateral clefts. boys with right clefts compared with boys with left clefts and healthy boys. Gross regional analyses demon- Design: Case-control study. strated that reductions in white matter were evident in both the cerebellum and the cerebrum in boys with right Setting: Tertiary care center. clefts. Furthermore, within the cerebrum, white matter volumes were particularly low in the frontal lobes and Participants: Boys aged 7 to 17 years with right (n=14) the occipital lobes. and left (n=19) clefts were compared with healthy age- matched boys (n=57). Conclusions: These preliminary results suggest that right clefts may be associated with more abnormalities Main Exposures: Structural brain measures were ob- in brain structure. More generally, laterality of a birth tained using magnetic resonance imaging. defect may have a significant effect on a developing organism. Outcome Measure: It was explored whether lateral- ity of clefts had a significant effect on brain structure. To this end, volumes of tissue types and various brain re- gions

Journal

JAMA Pediatrics – American Medical Association

Published: Aug 1, 2010

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