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Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents

Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human... ARTICLE Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project Helen Ding, MD, MSPH; Craig M. Wilson, MD; Kayvon Modjarrad, MD, PhD; Gerald McGwin Jr, PhD; Jianming Tang, DVM, PhD; Sten H. Vermund, MD, PhD Objective: To examine the prevalence and biopsycho- equate adherence (50%)—reported by 70.8% of re- social predictors of suboptimal virologic response to highly spondents—was associated with 60% reduced odds of sub- active antiretroviral therapy (HAART) among human im- optimal virologic suppression in a multivariable logistic munodeficiency virus–infected adolescents. regression model (adjusted odds ratio = 0.4; 95% confi- dence interval, 0.2-1.0). Exposure to suboptimal anti- Design: Population-based cohort study. retroviral therapy prior to HAART, on the other hand, was associated with more than 2-fold increased odds of Setting: Sixteen academic medical centers across 13 cit- suboptimal virologic response (adjusted odds ra- ies in the United States. tio = 2.6; 95% confidence interval, 1.1-5.7). Participants: One hundred fifty-four human immuno- Conclusions: Fully two-thirds of human immunodefi- deficiency virus–infected adolescents who presented for ciency virus–infected adolescents in the current study at least 2 consecutive visits after initiation of HAART. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents

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References (49)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2009.204
pmid
19996046
Publisher site
See Article on Publisher Site

Abstract

ARTICLE Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project Helen Ding, MD, MSPH; Craig M. Wilson, MD; Kayvon Modjarrad, MD, PhD; Gerald McGwin Jr, PhD; Jianming Tang, DVM, PhD; Sten H. Vermund, MD, PhD Objective: To examine the prevalence and biopsycho- equate adherence (50%)—reported by 70.8% of re- social predictors of suboptimal virologic response to highly spondents—was associated with 60% reduced odds of sub- active antiretroviral therapy (HAART) among human im- optimal virologic suppression in a multivariable logistic munodeficiency virus–infected adolescents. regression model (adjusted odds ratio = 0.4; 95% confi- dence interval, 0.2-1.0). Exposure to suboptimal anti- Design: Population-based cohort study. retroviral therapy prior to HAART, on the other hand, was associated with more than 2-fold increased odds of Setting: Sixteen academic medical centers across 13 cit- suboptimal virologic response (adjusted odds ra- ies in the United States. tio = 2.6; 95% confidence interval, 1.1-5.7). Participants: One hundred fifty-four human immuno- Conclusions: Fully two-thirds of human immunodefi- deficiency virus–infected adolescents who presented for ciency virus–infected adolescents in the current study at least 2 consecutive visits after initiation of HAART.

Journal

JAMA Pediatrics – American Medical Association

Published: Dec 1, 2009

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