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Therapy for Acute Otitis Media: Preference of Parents for Oral or Parenteral Antibiotic

Therapy for Acute Otitis Media: Preference of Parents for Oral or Parenteral Antibiotic Abstract Objective: To determine if parents prefer single-dose intramuscular (IM) therapy or standard 10-day oral therapy for treatment of acute otitis media (AOM). Design: Parents were asked their preference at the time their child was enrolled in a randomized controlled trial comparing the clinical efficacy of single-dose IM ceftriaxone sodium with 10 days of oral amoxicillin and clavulanate potassium for AOM. Additional information was collected at days 3 to 5 and 14 to 16 after the initiation of the therapy. Setting: Primarily private practices; 15 sites. Patients: For this study, 648 children aged 3 months to 6 years were randomly assigned to receive IM (n=327) or oral (n=321) therapy. Results: The groups were equivalent in all measured sociodemographic factors. At the time of enrollment, 85% of parents expressed a preference for single-dose IM therapy. At days 3 to 5, no differences were reported in days children were absent from school or day care, parental absence from work, or loss of sleep by children. However, more parents with children in the IM therapy group than in the oral therapy group reported loss of sleep by the parent (35% vs 26%, P=.02, χ2). At days 14 to 16, more parents with children in the IM group reported being "very satisfied" with the antibiotic (65%) compared with parents whose children were assigned to the oral therapy group (38%, P<.001). In comparing current therapy to past oral therapy for AOM, 71% of the parents with children in the IM therapy group reported more satisfaction with current therapy, in contrast to 21% of parents with children in the oral therapy group (P<.001). Of the parents, 83% indicated they would prefer singledose IM therapy for AOM in the future. Conclusion: All of the parents prefer single-dose IM therapy for AOM over standard 10-day oral therapy.(Arch Pediatr Adolesc Med. 1996;150:396-399) References 1. Williams RL, Maiman LA, Broadbent DN, et al. Educational strategies to improve compliance with an antibiotic regimen . AJDC . 1986;140:214-220. 2. Demers DM, Chan DS, Bass JW. Antimicrobial drug suspensions: a blinded comparison of taste of twelve common pediatric drugs including cefixime, cefpodoxime, cefprozil and loracarbef . Pediatr Infect Dis J . 1994;13:87-89.Crossref 3. Lieu TA, Cochi SL, Black SB, et al. Cost-effectiveness of a routine varicella vaccination program for US children . JAMA . 1994;271:375-381.Crossref 4. Barnett EB, Klein JO, Cabral H, Kharasch S, Teele DW. Comparison of ceftriaxone and trimethoprim sulfamethoxazole for acute otitis media. Pediatrica. In press. 5. Green SM, Rothrock SG. Single-dose intramuscular ceftriaxone for acute otitis media in children . Pediatrics . 1993;91:23-30. 6. Chamberlain JM, Ochsenschlager DW, Boenning DA, Klein BL. Single-dose ceftriaxone for the treatment of acute otitis media with effusion . AJDC . 1992;146: 470. Abstract. 7. Fletcher RH, Fletcher SW, Wagner EH. Clinical Epidemiology . 2nd ed. Baltimore, Md: Williams & Wilkins; 1988. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pediatrics & Adolescent Medicine American Medical Association

Therapy for Acute Otitis Media: Preference of Parents for Oral or Parenteral Antibiotic

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
1072-4710
eISSN
1538-3628
DOI
10.1001/archpedi.1996.02170290062010
Publisher site
See Article on Publisher Site

Abstract

Abstract Objective: To determine if parents prefer single-dose intramuscular (IM) therapy or standard 10-day oral therapy for treatment of acute otitis media (AOM). Design: Parents were asked their preference at the time their child was enrolled in a randomized controlled trial comparing the clinical efficacy of single-dose IM ceftriaxone sodium with 10 days of oral amoxicillin and clavulanate potassium for AOM. Additional information was collected at days 3 to 5 and 14 to 16 after the initiation of the therapy. Setting: Primarily private practices; 15 sites. Patients: For this study, 648 children aged 3 months to 6 years were randomly assigned to receive IM (n=327) or oral (n=321) therapy. Results: The groups were equivalent in all measured sociodemographic factors. At the time of enrollment, 85% of parents expressed a preference for single-dose IM therapy. At days 3 to 5, no differences were reported in days children were absent from school or day care, parental absence from work, or loss of sleep by children. However, more parents with children in the IM therapy group than in the oral therapy group reported loss of sleep by the parent (35% vs 26%, P=.02, χ2). At days 14 to 16, more parents with children in the IM group reported being "very satisfied" with the antibiotic (65%) compared with parents whose children were assigned to the oral therapy group (38%, P<.001). In comparing current therapy to past oral therapy for AOM, 71% of the parents with children in the IM therapy group reported more satisfaction with current therapy, in contrast to 21% of parents with children in the oral therapy group (P<.001). Of the parents, 83% indicated they would prefer singledose IM therapy for AOM in the future. Conclusion: All of the parents prefer single-dose IM therapy for AOM over standard 10-day oral therapy.(Arch Pediatr Adolesc Med. 1996;150:396-399) References 1. Williams RL, Maiman LA, Broadbent DN, et al. Educational strategies to improve compliance with an antibiotic regimen . AJDC . 1986;140:214-220. 2. Demers DM, Chan DS, Bass JW. Antimicrobial drug suspensions: a blinded comparison of taste of twelve common pediatric drugs including cefixime, cefpodoxime, cefprozil and loracarbef . Pediatr Infect Dis J . 1994;13:87-89.Crossref 3. Lieu TA, Cochi SL, Black SB, et al. Cost-effectiveness of a routine varicella vaccination program for US children . JAMA . 1994;271:375-381.Crossref 4. Barnett EB, Klein JO, Cabral H, Kharasch S, Teele DW. Comparison of ceftriaxone and trimethoprim sulfamethoxazole for acute otitis media. Pediatrica. In press. 5. Green SM, Rothrock SG. Single-dose intramuscular ceftriaxone for acute otitis media in children . Pediatrics . 1993;91:23-30. 6. Chamberlain JM, Ochsenschlager DW, Boenning DA, Klein BL. Single-dose ceftriaxone for the treatment of acute otitis media with effusion . AJDC . 1992;146: 470. Abstract. 7. Fletcher RH, Fletcher SW, Wagner EH. Clinical Epidemiology . 2nd ed. Baltimore, Md: Williams & Wilkins; 1988.

Journal

Archives of Pediatrics & Adolescent Medicine – American Medical Association

Published: Apr 1, 1996

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