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The Pediatrician and Cancer Prevention: Accepting the Present, Changing the Future

The Pediatrician and Cancer Prevention: Accepting the Present, Changing the Future Abstract DEVELOPMENT OF curative therapies for many childhood cancers is a true success story of pediatrics. For example, acute lymphoblastic leukemia in children was practically incurable in 1950; now, 70% to 80% of the cases of childhood acute lymphoblastic leukemia are cured. Similar or even better cure rates are seen with Hodgkin's disease, non-Hodgkin's lymphoma, and Wilms' tumor. Encouraging increases in relapse-free survival rates also are observed in children with neuroblastoma and rhabdomyosarcoma. These remarkable statistics are a testimonial to the thoughtful, innovative, and sequential treatment protocols developed by large single institutions and by multi-institutional national cooperative clinical research groups such as the Children's Cancer Group and the Pediatric Oncology Group. Within the last decade, elegant studies have elucidated the molecular biological bases for the development of several pediatric neoplastic diseases and the putative mechanisms for predisposition to cancer in children with certain immunologic, hematologic, or genetic syndromes such as References 1. Knudson A, VandeWoude GF, Friend SH, Cavenee WK, Brodeur GM. Developmental genetics and childhood cancer . Cancer Res . 1991;51:5435-5439. 2. Li FP, Fraumeni JF. Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome . J Natl Cancer Inst . 1969;43:1365-1373. 3. Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms . Science . 1990:250: 1233-1238.Crossref 4. Li FP, Fraumeni JF. Predictive testing for inherited mutations in cancer-susceptibility genes . J Clin Oncol . 1992;10:1203-1204. 5. Miller AB, Chamberlain J, Day NE, Hakam M, Prorok PC. Report on a workshop of the UICC project on evaluation of screening for cancer . Int J Cancer . 1990;46:761-769.Crossref 6. Murphy SB, Cohn SL, Craft AW, et al. Do children benefit from mass screening for neuroblastoma? Lancet . 1991;337:344-346.Crossref 7. Hammond GD. Opportunities for cancer prevention and early detection among children . Cancer . 1988;62:1829-1832.Crossref 8. Feychting M, Ahlbom A. Magnetic fields and cancer in children residing near Swedish high-voltage power lines . Am J Epidemiol . 1993;138:467-481. 9. Schwartzbaum JA, George SL, Pratt CB, Davis B. An exploratory study of environmental and medical factors potentially related to childhood cancer . Med Pediatr Oncol . 1991;19:115-121.Crossref 10. Mettlin C. Dietary cancer prevention in children . Cancer . 1993;71( (suppl) ):3367-3369.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pediatrics & Adolescent Medicine American Medical Association

The Pediatrician and Cancer Prevention: Accepting the Present, Changing the Future

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
1072-4710
eISSN
1538-3628
DOI
10.1001/archpedi.1995.02170140015002
Publisher site
See Article on Publisher Site

Abstract

Abstract DEVELOPMENT OF curative therapies for many childhood cancers is a true success story of pediatrics. For example, acute lymphoblastic leukemia in children was practically incurable in 1950; now, 70% to 80% of the cases of childhood acute lymphoblastic leukemia are cured. Similar or even better cure rates are seen with Hodgkin's disease, non-Hodgkin's lymphoma, and Wilms' tumor. Encouraging increases in relapse-free survival rates also are observed in children with neuroblastoma and rhabdomyosarcoma. These remarkable statistics are a testimonial to the thoughtful, innovative, and sequential treatment protocols developed by large single institutions and by multi-institutional national cooperative clinical research groups such as the Children's Cancer Group and the Pediatric Oncology Group. Within the last decade, elegant studies have elucidated the molecular biological bases for the development of several pediatric neoplastic diseases and the putative mechanisms for predisposition to cancer in children with certain immunologic, hematologic, or genetic syndromes such as References 1. Knudson A, VandeWoude GF, Friend SH, Cavenee WK, Brodeur GM. Developmental genetics and childhood cancer . Cancer Res . 1991;51:5435-5439. 2. Li FP, Fraumeni JF. Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome . J Natl Cancer Inst . 1969;43:1365-1373. 3. Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms . Science . 1990:250: 1233-1238.Crossref 4. Li FP, Fraumeni JF. Predictive testing for inherited mutations in cancer-susceptibility genes . J Clin Oncol . 1992;10:1203-1204. 5. Miller AB, Chamberlain J, Day NE, Hakam M, Prorok PC. Report on a workshop of the UICC project on evaluation of screening for cancer . Int J Cancer . 1990;46:761-769.Crossref 6. Murphy SB, Cohn SL, Craft AW, et al. Do children benefit from mass screening for neuroblastoma? Lancet . 1991;337:344-346.Crossref 7. Hammond GD. Opportunities for cancer prevention and early detection among children . Cancer . 1988;62:1829-1832.Crossref 8. Feychting M, Ahlbom A. Magnetic fields and cancer in children residing near Swedish high-voltage power lines . Am J Epidemiol . 1993;138:467-481. 9. Schwartzbaum JA, George SL, Pratt CB, Davis B. An exploratory study of environmental and medical factors potentially related to childhood cancer . Med Pediatr Oncol . 1991;19:115-121.Crossref 10. Mettlin C. Dietary cancer prevention in children . Cancer . 1993;71( (suppl) ):3367-3369.Crossref

Journal

Archives of Pediatrics & Adolescent Medicine – American Medical Association

Published: Feb 1, 1995

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