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SPECIAL FEATURE

SPECIAL FEATURE Abstract A 14-year-old previously healthy boy presented with a 2-month history of a painless "rash" on his left flank and right thigh. He also complained of intermittent headache, and his parents believed that his personality had changed recently. He had no history of fever, anorexia, weight loss, or trauma. On physical examination, he was an alert and cooperative boy. There was no evidence of papilledema, and results of his neurologic examination were entirely normal. His abdomen was soft, nontender, and without masses or organomegaly. An indurated violaceous lesion measuring 3×8 cm was noted on his right thigh (Fig 1). A similar 5×4-cm lesion was also noted on his left flank. Laboratory findings were as follows: leukocyte count, 8.6×109/L with 0.50 segmented neutrophilis, 0.45 lymphocytes, and 0.04 monocytes; hematocrit, 0.41; erythrocyte sedimentation rate, 2 mm/h; and prothrombin time and activated partial thromboplastin time, normal. Cerebral spinal fluid had a white blood cell count of 23×106/L with 0.90 polymorphonuclear cells, 0.05 monocytes, and References 1. Liebow AA, Carrington CRB, Friedman PJ. Lymphomatoid granulomatosis . Hum Pathol . 1972;3:457-558.Crossref 2. Katzenstein AL, Carrington CRB, Liebow AA. Lymphomatoid granulomatosis: a clinicopathologic study of 152 cases . Cancer . 1979;43:360-373.Crossref 3. Carlson KC, Gibson LE. Cutaneous signs of lymphomatoid granulomatosis . Arch Dermatol . 1991;127:1693-1698.Crossref 4. Bekassy AN, Camerson R. Garwicz S, Laurin S, Wiebe T. Lymphomatoid granulomatosis during treatment of acute lymphoblastic leukemia in a 6-year-old girl . Am J Pediatr Hematol Oncol . (Winter) 1985:377-380. 5. Shen SC, Heuser ET, Landing BH, Siegel S, Cohen S. Lymphomatoid granulomatosislike lesions in a child with leukemia in remission . Hum Pathol . 1981;12:276-280.Crossref 6. Lehman TJA, Church JA, Isaacs H. Lymphomatoid granulomatosis in a 13-month-old infant . J Rheumatol . 1989;16:235-238. 7. Fauci AS, Haynes BF, Costa J, Katz P, Wolff S. Lymphomatoid granulomatosis: prospective clinical and therapeutic experience over 10 years . N Engl J Med . 1983;306:68-74.Crossref 8. Lipford EH, Margolic JB, Longo DL, Fauci AS, Jaffe ES. Angiocentric immunoproliferative lesions: a clinicopathologic spectrum of post-thymic T-cell proliferations . Blood . 1988;72:1674-1681. 9. Bernstein ML, Reece ER, de Chadarevian JP, Koch PA. Bone marrow transplantation in lymphomatoid granulomatosis . Cancer . 1986;58:969-972.Crossref 10. Weiss JW, Winter MW, Phyliky RL, Banks PM. Peripheral T-cell lymphomas: histologic, immunohistologic, and clinical characterization . Mayo Clin Proc . 1986;61:411-426.Crossref 11. Gaulard PG, Henni T, Marolleau JP, et al. Lethal midline granuloma (polymorphic reticulosis) and lymphomatoid granulomatosis . Cancer . 1988; 62:705-710.Crossref 12. Katzenstein AL, Peiper SC. Detection of Epstein-Barr virus genomes in lymphomatoid granulomatosis: analysis of 29 cases by polymerase chain reaction technique . Mod Pathol . 1990;4:435-441. 13. Mittal K, Neri A, Feiner H, Schinell R, Alfonso F. Lymphomatoid granulomatosis in the acquired immunodeficiency syndrome: evidence of Epstein-Barr virus infection and B-cell clonal selection without myc rearrangement . Cancer . 1990;65:1345-1349.Crossref 14. Troussard X, Galateau F, Gaulard P, et al. Lymphomatoid granulomatosis in a patient with acute myeloblastic leukemia in remission . Cancer . 1990;65:107-111.Crossref 15. Pearon ADJ, Kirpalani H, Ashcroft T, Bain H, Craft AW. Lymphomatoid granulomatosis in a 10-year-old boy . BMJ . 1983;286:1313-1314.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

SPECIAL FEATURE

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1993.02160300099035
Publisher site
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Abstract

Abstract A 14-year-old previously healthy boy presented with a 2-month history of a painless "rash" on his left flank and right thigh. He also complained of intermittent headache, and his parents believed that his personality had changed recently. He had no history of fever, anorexia, weight loss, or trauma. On physical examination, he was an alert and cooperative boy. There was no evidence of papilledema, and results of his neurologic examination were entirely normal. His abdomen was soft, nontender, and without masses or organomegaly. An indurated violaceous lesion measuring 3×8 cm was noted on his right thigh (Fig 1). A similar 5×4-cm lesion was also noted on his left flank. Laboratory findings were as follows: leukocyte count, 8.6×109/L with 0.50 segmented neutrophilis, 0.45 lymphocytes, and 0.04 monocytes; hematocrit, 0.41; erythrocyte sedimentation rate, 2 mm/h; and prothrombin time and activated partial thromboplastin time, normal. Cerebral spinal fluid had a white blood cell count of 23×106/L with 0.90 polymorphonuclear cells, 0.05 monocytes, and References 1. Liebow AA, Carrington CRB, Friedman PJ. Lymphomatoid granulomatosis . Hum Pathol . 1972;3:457-558.Crossref 2. Katzenstein AL, Carrington CRB, Liebow AA. Lymphomatoid granulomatosis: a clinicopathologic study of 152 cases . Cancer . 1979;43:360-373.Crossref 3. Carlson KC, Gibson LE. Cutaneous signs of lymphomatoid granulomatosis . Arch Dermatol . 1991;127:1693-1698.Crossref 4. Bekassy AN, Camerson R. Garwicz S, Laurin S, Wiebe T. Lymphomatoid granulomatosis during treatment of acute lymphoblastic leukemia in a 6-year-old girl . Am J Pediatr Hematol Oncol . (Winter) 1985:377-380. 5. Shen SC, Heuser ET, Landing BH, Siegel S, Cohen S. Lymphomatoid granulomatosislike lesions in a child with leukemia in remission . Hum Pathol . 1981;12:276-280.Crossref 6. Lehman TJA, Church JA, Isaacs H. Lymphomatoid granulomatosis in a 13-month-old infant . J Rheumatol . 1989;16:235-238. 7. Fauci AS, Haynes BF, Costa J, Katz P, Wolff S. Lymphomatoid granulomatosis: prospective clinical and therapeutic experience over 10 years . N Engl J Med . 1983;306:68-74.Crossref 8. Lipford EH, Margolic JB, Longo DL, Fauci AS, Jaffe ES. Angiocentric immunoproliferative lesions: a clinicopathologic spectrum of post-thymic T-cell proliferations . Blood . 1988;72:1674-1681. 9. Bernstein ML, Reece ER, de Chadarevian JP, Koch PA. Bone marrow transplantation in lymphomatoid granulomatosis . Cancer . 1986;58:969-972.Crossref 10. Weiss JW, Winter MW, Phyliky RL, Banks PM. Peripheral T-cell lymphomas: histologic, immunohistologic, and clinical characterization . Mayo Clin Proc . 1986;61:411-426.Crossref 11. Gaulard PG, Henni T, Marolleau JP, et al. Lethal midline granuloma (polymorphic reticulosis) and lymphomatoid granulomatosis . Cancer . 1988; 62:705-710.Crossref 12. Katzenstein AL, Peiper SC. Detection of Epstein-Barr virus genomes in lymphomatoid granulomatosis: analysis of 29 cases by polymerase chain reaction technique . Mod Pathol . 1990;4:435-441. 13. Mittal K, Neri A, Feiner H, Schinell R, Alfonso F. Lymphomatoid granulomatosis in the acquired immunodeficiency syndrome: evidence of Epstein-Barr virus infection and B-cell clonal selection without myc rearrangement . Cancer . 1990;65:1345-1349.Crossref 14. Troussard X, Galateau F, Gaulard P, et al. Lymphomatoid granulomatosis in a patient with acute myeloblastic leukemia in remission . Cancer . 1990;65:107-111.Crossref 15. Pearon ADJ, Kirpalani H, Ashcroft T, Bain H, Craft AW. Lymphomatoid granulomatosis in a 10-year-old boy . BMJ . 1983;286:1313-1314.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1993

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