Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Mesenchymal Hamartoma of Liver: A Regional Ischemic Lesion of a Sequestered Lobe

Mesenchymal Hamartoma of Liver: A Regional Ischemic Lesion of a Sequestered Lobe Abstract • Objective. —To evaluate histologic and gross features of mesenchymal hamartoma of liver and similar lesions in relation to determining likely pathogenesis. Design. —Case series of patients presenting to a tertiary care hospital over 16 years. Patients. —Three children with mesenchymal hamartoma ranging from newborn to 11 months of age and one 12-year-old girl with torsion of an accessory lobe of liver. Main Outcome Measures. —Similarity of gross vascular and segmented anomalies as well as apparent consequent histologic features of mesenchymal hamartoma to those of torsion of an accessory lobe of liver indicate that they are pathogenetically related. Results. —Dissecting microscopic examination revealed a single vascular supply in one case and remote thrombi in two cases of mesenchymal hamartoma evaluated. The histologic features of mesenchymal hamartoma (hypocellular central zone and hypercellular periphery) were duplicated in the lobe of liver with torsion. Conclusions. —Mesenchymal hamartoma represents a lesion with an anomalous solitary vascular supply that may evolve into its specific pattern with stromal cysts as a result of early ischemic changes.(AJDC. 1993;147:193-196) References 1. Edmondson HA. Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood . AJDC . 1956;91:168-186. 2. Keeling JW. Liver tumors in infancy and childhood . J Pathol. 1971;103: 69-85.Crossref 3. Okeda R. Mesenchymal hamartoma of the liver: an autopsy case with serial sections and some comments on this pathogenesis . Acta Pathol Jpn . 1976;26:229-236. 4. Dehner LP, Ewing SL, Sumner HW. Infantile mesenchymal hamartoma of the liver: histologic and ultrastructural observations . Arch Pathol Lab Med. 1975;99:379-382. 5. Stocker JT, Ishak KG. Mesenchymal hamartoma . Pediatr Pathol. 1983; 1:245-267.Crossref 6. Sutton CA, Eller JL. Mesenchymal hamartoma of the liver . Cancer . 1968;22:29-34.Crossref 7. Dehner LP. Liver, gallbladder, and extrahepatic biliary tract . In: Dehner LP, ed. Pediatric Surgical Pathology . Baltimore, Md: Williams & Wilkins; 1987:482. 8. Rosenbaum DM, Mindell HJ. Ultrasonographic findings in mesenchymal hamartoma of the liver . Radiology . 1981;138:425. 9. Weinberg AG, Feingold MJ. Primary hepatic tumors in childhood . In: Feingold MJ, ed. Pathology of Neoplasia in Children and Adolescents . Philadelphia, Pa: WB Saunders Co; 1986:333-372. 10. MacSween RNM, Anthony PP, Scheuer PJ. Pathophysiology of the liver . In: MacSween RNM, ed. Pathology of the Liver . New York, NY: Churchill Livingstone Inc; 1987:52-53. 11. Ishak KG, Rabin L. Benign tumors of the liver . Med Clin North Am . 1975;59:995-1013. 12. Stocker JT, Ishak KG. Focal nodular hyperplasia of the liver . Cancer . 1981;48:336-345.Crossref 13. Wanless IR, Mawdsley C, Adams R. On the pathogenesis of focal nodular hyperplasia of the liver . Hepatology . 1985;5:1194-1200.Crossref 14. Masson P. Human Tumors . Detroit, Mich: Wayne State University Press; 1970. 15. Dooley JS, Li AKC, Scheuer PJ. A giant cystic mesenchymal hamartoma of the liver: diagnosis, management and study of cyst fluid . Gastroenterology . 1983;85:958-966. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Mesenchymal Hamartoma of Liver: A Regional Ischemic Lesion of a Sequestered Lobe

Loading next page...
 
/lp/american-medical-association/mesenchymal-hamartoma-of-liver-a-regional-ischemic-lesion-of-a-2L64Vz3gt2

References (21)

Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1993.02160260083027
Publisher site
See Article on Publisher Site

Abstract

Abstract • Objective. —To evaluate histologic and gross features of mesenchymal hamartoma of liver and similar lesions in relation to determining likely pathogenesis. Design. —Case series of patients presenting to a tertiary care hospital over 16 years. Patients. —Three children with mesenchymal hamartoma ranging from newborn to 11 months of age and one 12-year-old girl with torsion of an accessory lobe of liver. Main Outcome Measures. —Similarity of gross vascular and segmented anomalies as well as apparent consequent histologic features of mesenchymal hamartoma to those of torsion of an accessory lobe of liver indicate that they are pathogenetically related. Results. —Dissecting microscopic examination revealed a single vascular supply in one case and remote thrombi in two cases of mesenchymal hamartoma evaluated. The histologic features of mesenchymal hamartoma (hypocellular central zone and hypercellular periphery) were duplicated in the lobe of liver with torsion. Conclusions. —Mesenchymal hamartoma represents a lesion with an anomalous solitary vascular supply that may evolve into its specific pattern with stromal cysts as a result of early ischemic changes.(AJDC. 1993;147:193-196) References 1. Edmondson HA. Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood . AJDC . 1956;91:168-186. 2. Keeling JW. Liver tumors in infancy and childhood . J Pathol. 1971;103: 69-85.Crossref 3. Okeda R. Mesenchymal hamartoma of the liver: an autopsy case with serial sections and some comments on this pathogenesis . Acta Pathol Jpn . 1976;26:229-236. 4. Dehner LP, Ewing SL, Sumner HW. Infantile mesenchymal hamartoma of the liver: histologic and ultrastructural observations . Arch Pathol Lab Med. 1975;99:379-382. 5. Stocker JT, Ishak KG. Mesenchymal hamartoma . Pediatr Pathol. 1983; 1:245-267.Crossref 6. Sutton CA, Eller JL. Mesenchymal hamartoma of the liver . Cancer . 1968;22:29-34.Crossref 7. Dehner LP. Liver, gallbladder, and extrahepatic biliary tract . In: Dehner LP, ed. Pediatric Surgical Pathology . Baltimore, Md: Williams & Wilkins; 1987:482. 8. Rosenbaum DM, Mindell HJ. Ultrasonographic findings in mesenchymal hamartoma of the liver . Radiology . 1981;138:425. 9. Weinberg AG, Feingold MJ. Primary hepatic tumors in childhood . In: Feingold MJ, ed. Pathology of Neoplasia in Children and Adolescents . Philadelphia, Pa: WB Saunders Co; 1986:333-372. 10. MacSween RNM, Anthony PP, Scheuer PJ. Pathophysiology of the liver . In: MacSween RNM, ed. Pathology of the Liver . New York, NY: Churchill Livingstone Inc; 1987:52-53. 11. Ishak KG, Rabin L. Benign tumors of the liver . Med Clin North Am . 1975;59:995-1013. 12. Stocker JT, Ishak KG. Focal nodular hyperplasia of the liver . Cancer . 1981;48:336-345.Crossref 13. Wanless IR, Mawdsley C, Adams R. On the pathogenesis of focal nodular hyperplasia of the liver . Hepatology . 1985;5:1194-1200.Crossref 14. Masson P. Human Tumors . Detroit, Mich: Wayne State University Press; 1970. 15. Dooley JS, Li AKC, Scheuer PJ. A giant cystic mesenchymal hamartoma of the liver: diagnosis, management and study of cyst fluid . Gastroenterology . 1983;85:958-966.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1993

There are no references for this article.