Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Meconium Aspiration

Meconium Aspiration Abstract The role of aspiration of meconium in producing respiratory disease in newborns, and its treatment, remain controversial. These issues have been reviewed in 19891 and 19922 in detail. In regard to causing respiratory disease, about 35% of infants born in the presence of thick meconium have meconium present below their vocal cords. However, only about 10% of these infants have significant respiratory dysfunction.1,2 Even the severity of their roentgenographic findings does not correlate well with their degree of respiratory distress, and fewer than half of those with abnormal chest roentgenograms have respiratory problems.3,4 Hence, a wide spectrum of respiratory symptoms may be associated with the presence of meconium in the trachea and the roentgenographic findings of patchy infiltrates. Applying the diagnostic term meconium aspiration syndrome (MAS) to this triad suggests a cause-and-effect relationship between the meconium and the respiratory symptoms in all of these infants. This References 1. Holtzman RB, Banzhaf WC, Silver RK, Hageman JR. Perinatal management of meconium staining of the amniotic fluid . Clin Perinatol . 1989;16:825-838. 2. Katz VL, Bowes WA. Meconium aspiration syndrome: reflections on a murky subject . Am J Obstet Gynecol . 1992;166:171-183.Crossref 3. Gregory GA, Gooding CA, Phibbs RH, Tooley WH. Meconium aspiration in infants: a prospective study . J Pediatr . 1974;85:848-852.Crossref 4. Fox WW, Gewitz MH, Dinwiddie R, Drummond WH, Peckham GJ. Pulmonary hypertension in the perinatal aspiration syndromes . Pediatrics . 1977;59:205-211. 5. Davis RO, Philips JB, Harris BA, Wilson ER, Huddleston JF. Fatal meconium aspiration syndrome occurring despite airway management considered appropriate . Am J Obstet Gynecol . 1985;151:731-736.Crossref 6. Falciglia HS. Failure to prevent meconium aspiration syndrome . Obstet Gynecol . 1988;71: 349-353. 7. Rossi EM, Philipson EH, Williams TG, Kalhan SC. Meconium aspiration syndrome: intrapartum and neonatal attributes . Am J Obstet Gynecol . 1989;161:1106-1110.Crossref 8. Murphy JD, Vawter GF, Reid LM. Pulmonary vascular disease in fatal meconium aspiration . J Pediatr . 1984;104:758-762.Crossref 9. Mammel MC, Gordon MJ, Connett JE, Boros SJ. Comparison of high-frequency jet ventilation and conventional mechanical ventilation in a meconium aspiration model . J Pediatr . 1983;103: 630-637.Crossref 10. Trindade O, Goldberg RN, Bancalari E, Dickstein P, Ellison J, Gerhardt T. Conventional vs high-frequency jet ventilation in a piglet model of meconium aspiration: comparison of pulmonary and hemodynamic effects . J Pediatr . 1985;107:115-120.Crossref 11. Tyler DC, Murphy J, Cheney FW. Mechanical and chemical damage to lung tissue caused by meconium aspiration . Pediatrics. 1978;62: 454-459. 12. Jovanovic R, Nguyen H. Experimental meconium aspiration in guinea pigs . Obstet Gynecol . 1989;73:652. 13. Wiswell TE, Foster NH, Slayter MV. Management of a piglet model of the meconium aspiration syndrome with high frequency or conventional ventilation . AJDC . 1992;146: 1287-1293. 14. Moses D, Holm BA, Spitale P, Liu M, Enhorning G. Inhibition of pulmonary surfactant function by meconium . Am J Obstet Gynecol . 1991;164:477-481.Crossref 15. Paranka MS, Walsh WF, Stancombe BB. Surfactant lavage in a piglet model of meconium aspiration syndrome . Pediatr Res . 1992;31:625-628.Crossref 16. Carter MJM, Gerstmann DR, Clark MRH, et al. High-frequency oscillatory ventilation and extracorporeal membrane oxygenation for the treatment of acute neonatal respiratory failure . Pediatrics . 1990;85:159-164. 17. Auten RL, Notter RH, Kendig JW, Davis JM, Shapiro DL. Surfactant treatment of full-term newborns with respiratory failure . Pediatrics . 1991;87:101-107. 18. Wiswell TE, Tuggle JM, Turner BS. Meconium aspiration syndrome: have we made a difference? Pediatrics . 1990;85:715-721. 19. Linder N, Aranda JV, Tsur M. Need for endotracheal intubation and suction in meconium-stained neonates . J Pediatr . 1988;112:613-615.Crossref 20. Wenstrom KD, Parsons MT. The prevention of meconium aspiration in labor using amnioinfusion . Obstet Gynecol . 1989;73:647-651. 21. Strong TH, Hetzler G, Sarno AP. Prophylactic intrapartum amnioinfusion: a randomized clinical trial . Am J Obstet Gynecol . 1990;162: 1370-1375.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Meconium Aspiration

Download PDF
2 pages

Loading next page...
 
/lp/american-medical-association/meconium-aspiration-dj9C7705UK

References (21)

Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1992.02160230040012
Publisher site
See Article on Publisher Site

Abstract

Abstract The role of aspiration of meconium in producing respiratory disease in newborns, and its treatment, remain controversial. These issues have been reviewed in 19891 and 19922 in detail. In regard to causing respiratory disease, about 35% of infants born in the presence of thick meconium have meconium present below their vocal cords. However, only about 10% of these infants have significant respiratory dysfunction.1,2 Even the severity of their roentgenographic findings does not correlate well with their degree of respiratory distress, and fewer than half of those with abnormal chest roentgenograms have respiratory problems.3,4 Hence, a wide spectrum of respiratory symptoms may be associated with the presence of meconium in the trachea and the roentgenographic findings of patchy infiltrates. Applying the diagnostic term meconium aspiration syndrome (MAS) to this triad suggests a cause-and-effect relationship between the meconium and the respiratory symptoms in all of these infants. This References 1. Holtzman RB, Banzhaf WC, Silver RK, Hageman JR. Perinatal management of meconium staining of the amniotic fluid . Clin Perinatol . 1989;16:825-838. 2. Katz VL, Bowes WA. Meconium aspiration syndrome: reflections on a murky subject . Am J Obstet Gynecol . 1992;166:171-183.Crossref 3. Gregory GA, Gooding CA, Phibbs RH, Tooley WH. Meconium aspiration in infants: a prospective study . J Pediatr . 1974;85:848-852.Crossref 4. Fox WW, Gewitz MH, Dinwiddie R, Drummond WH, Peckham GJ. Pulmonary hypertension in the perinatal aspiration syndromes . Pediatrics . 1977;59:205-211. 5. Davis RO, Philips JB, Harris BA, Wilson ER, Huddleston JF. Fatal meconium aspiration syndrome occurring despite airway management considered appropriate . Am J Obstet Gynecol . 1985;151:731-736.Crossref 6. Falciglia HS. Failure to prevent meconium aspiration syndrome . Obstet Gynecol . 1988;71: 349-353. 7. Rossi EM, Philipson EH, Williams TG, Kalhan SC. Meconium aspiration syndrome: intrapartum and neonatal attributes . Am J Obstet Gynecol . 1989;161:1106-1110.Crossref 8. Murphy JD, Vawter GF, Reid LM. Pulmonary vascular disease in fatal meconium aspiration . J Pediatr . 1984;104:758-762.Crossref 9. Mammel MC, Gordon MJ, Connett JE, Boros SJ. Comparison of high-frequency jet ventilation and conventional mechanical ventilation in a meconium aspiration model . J Pediatr . 1983;103: 630-637.Crossref 10. Trindade O, Goldberg RN, Bancalari E, Dickstein P, Ellison J, Gerhardt T. Conventional vs high-frequency jet ventilation in a piglet model of meconium aspiration: comparison of pulmonary and hemodynamic effects . J Pediatr . 1985;107:115-120.Crossref 11. Tyler DC, Murphy J, Cheney FW. Mechanical and chemical damage to lung tissue caused by meconium aspiration . Pediatrics. 1978;62: 454-459. 12. Jovanovic R, Nguyen H. Experimental meconium aspiration in guinea pigs . Obstet Gynecol . 1989;73:652. 13. Wiswell TE, Foster NH, Slayter MV. Management of a piglet model of the meconium aspiration syndrome with high frequency or conventional ventilation . AJDC . 1992;146: 1287-1293. 14. Moses D, Holm BA, Spitale P, Liu M, Enhorning G. Inhibition of pulmonary surfactant function by meconium . Am J Obstet Gynecol . 1991;164:477-481.Crossref 15. Paranka MS, Walsh WF, Stancombe BB. Surfactant lavage in a piglet model of meconium aspiration syndrome . Pediatr Res . 1992;31:625-628.Crossref 16. Carter MJM, Gerstmann DR, Clark MRH, et al. High-frequency oscillatory ventilation and extracorporeal membrane oxygenation for the treatment of acute neonatal respiratory failure . Pediatrics . 1990;85:159-164. 17. Auten RL, Notter RH, Kendig JW, Davis JM, Shapiro DL. Surfactant treatment of full-term newborns with respiratory failure . Pediatrics . 1991;87:101-107. 18. Wiswell TE, Tuggle JM, Turner BS. Meconium aspiration syndrome: have we made a difference? Pediatrics . 1990;85:715-721. 19. Linder N, Aranda JV, Tsur M. Need for endotracheal intubation and suction in meconium-stained neonates . J Pediatr . 1988;112:613-615.Crossref 20. Wenstrom KD, Parsons MT. The prevention of meconium aspiration in labor using amnioinfusion . Obstet Gynecol . 1989;73:647-651. 21. Strong TH, Hetzler G, Sarno AP. Prophylactic intrapartum amnioinfusion: a randomized clinical trial . Am J Obstet Gynecol . 1990;162: 1370-1375.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Nov 1, 1992

There are no references for this article.