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Exacerbation of Tinea Corporis During Treatment With 1% Clotrimazole/0.05% Betamethasone Diproprionate (Lotrisone)

Exacerbation of Tinea Corporis During Treatment With 1% Clotrimazole/0.05% Betamethasone... Abstract Sir.—An 8-year-old girl with tinea corporis of the knee was treated with a combination product of 1% clotrimazole and 0.05% betamethasone diproprionate cream (Lotrisone). She had a prolonged course, with persistent pustules and inflammation that permanently scarred her knee. The histologic appearance was that of a Majocchi's granuloma, a fungal dermal abscess similar to a kerion. We postulate that the cause was local immunosuppression by the fluorinated steroid in this cream. Patient Report.—Eleven weeks before presentation, an 8-year-old girl had played in a barn in which many cats made their home. Nine weeks before presentation, she developed an erythematous, ring-shaped, scaly lesion on her right knee, diagnosed by her family physician as "ringworm." A combination cream containing 1% clotrimazole and 0.05% betamethasone diproprionate was prescribed to be applied twice daily until the lesion resolved. The cream was faithfully applied without occlusion for 9 weeks, but instead of References 1. Jacobs PH. Majocchi's granuloma (due to therapy with steroid and occlusion) . Cutis . 1986;38:23. 2. Ive FA, Marks R. Tinea incognito . Br Med J . 1968;3:149-152.Crossref 3. Barkey WF. Striae and persistent tinea corporis related to prolonged use of betamethasone diproprionate 0.05% cream/clotrimazole 1% cream (Lotrisone cream) . J Am Acad Dermatol . 1987; 17:518-519.Crossref 4. Cornell RC, Stoughton RB. The use of topical steroids in psoriasis . Dermatol Clin N Am . 1984;2:397-409. 5. Feldmann RJ, Maibach HI. Regional variation in percutaneous penetration of 14C cortisol in man . J Invest Dermatol . 1967;48:181-183. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Exacerbation of Tinea Corporis During Treatment With 1% Clotrimazole/0.05% Betamethasone Diproprionate (Lotrisone)

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1991.02160110014007
Publisher site
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Abstract

Abstract Sir.—An 8-year-old girl with tinea corporis of the knee was treated with a combination product of 1% clotrimazole and 0.05% betamethasone diproprionate cream (Lotrisone). She had a prolonged course, with persistent pustules and inflammation that permanently scarred her knee. The histologic appearance was that of a Majocchi's granuloma, a fungal dermal abscess similar to a kerion. We postulate that the cause was local immunosuppression by the fluorinated steroid in this cream. Patient Report.—Eleven weeks before presentation, an 8-year-old girl had played in a barn in which many cats made their home. Nine weeks before presentation, she developed an erythematous, ring-shaped, scaly lesion on her right knee, diagnosed by her family physician as "ringworm." A combination cream containing 1% clotrimazole and 0.05% betamethasone diproprionate was prescribed to be applied twice daily until the lesion resolved. The cream was faithfully applied without occlusion for 9 weeks, but instead of References 1. Jacobs PH. Majocchi's granuloma (due to therapy with steroid and occlusion) . Cutis . 1986;38:23. 2. Ive FA, Marks R. Tinea incognito . Br Med J . 1968;3:149-152.Crossref 3. Barkey WF. Striae and persistent tinea corporis related to prolonged use of betamethasone diproprionate 0.05% cream/clotrimazole 1% cream (Lotrisone cream) . J Am Acad Dermatol . 1987; 17:518-519.Crossref 4. Cornell RC, Stoughton RB. The use of topical steroids in psoriasis . Dermatol Clin N Am . 1984;2:397-409. 5. Feldmann RJ, Maibach HI. Regional variation in percutaneous penetration of 14C cortisol in man . J Invest Dermatol . 1967;48:181-183.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Nov 1, 1991

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