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Decreasing Severity of Chronic Uveitis in Children With Pauciarticular Arthritis

Decreasing Severity of Chronic Uveitis in Children With Pauciarticular Arthritis Abstract • We compared the current prevalence and severity of chronic uveitis in children with pauciarticular juvenile rheumatoid arthritis in Seattle, Wash, with that of children with the same condition in the same area in 1975. The prevalence of eye disease decreased from 45% in 1975 to 13% in 1989, and the proportion of patients with severe visual loss decreased from 21% in 1975 to none in 1989. We could not attribute these findings to differences in known risk factors for iritis, such as age, sex, or presence of antinuclear antibodies. There was no difference in the duration of follow-up between the two groups. It is possible that the decline in prevalence of uveitis reflects a referral bias for eye disease in the 1975 population. However, the decrease in disease severity remains unexplained and may represent more effective treatment, earlier surveillance for ocular disease, or a change in the frequency of ocular manifestations of this disease in the 1989 group. (AJDC. 1991;145:1026-1028) References 1. Petty RE, Cassidy JT, Sullivan DB. Clinical correlates of antinuclear antibodies in juvenile rheumatoid arthritis . J Pediatr . 1973;83:386-389.Crossref 2. Schaller JG, Johnson GD, Hulborow EJ, Ansell BM, Smiley WK. The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease) . Arthritis Rheum . 1974;17:409-416.Crossref 3. Rosenberg AM. Uveitis associated with juvenile rheumatoid arthritis . Semin Arthritis Rheum . 1987;16:158-173.Crossref 4. Chylack LT Jr. The ocular manifestations of juvenile rheumatoid arthritis . Arthritis Rheum . 1977;20:217-223. 5. Calabro JJ, Parrino R, Atchoo PD, Marchesano JM, Goldberg LS. Chronic iridocyclitis in juvenile rheumatoid arthritis . Arthritis Rheum . 1970;13:406-413.Crossref 6. Wolf MD, Lichter PR, Ragsdale CG. Prognostic factors in the uveitis of juvenile rheumatoid arthritis . Ophthalmology. 1987;94:1242-1248.Crossref 7. Schaller JG, Kupfer C, Wedgwood RJ. Iridocyclitis in juvenile rheumatoid arthritis . Pediatrics. 1969;44:92-100. 8. Schaller JG. Juvenile rheumatoid arthritis: series 1 . Arthritis Rheum . 1977;20:165-170.Crossref 9. Cassidy JT, Sullivan DB, Petty RE. Clinical patterns of chronic iridocyclitis in children with juvenile rheumatoid arthritis . Arthritis Rheum . 1977;20:224-226. 10. Fink CW. Patients with juvenile rheumatoid arthritis: a clinical study . Arthritis Rheum . 1977;20:183-184. 11. Brewer EJ, Bass J, Baum J, et al. Current proposed revision of JRA criteria . Arthritis Rheum . 1977;20:195-199. 12. Rosenberg AM, Oen KG. The relationship between ocular and articular disease activity in children with juvenile rheumatoid arthritis and associated uveitis . Arthritis Rheum . 1986;29:797-800.Crossref 13. Leak AM, Ansell BM. The relationship between ocular and articular disease activity in juvenile rheumatoid arthritis complicated by chronic anterior uveitis . Arthritis Rheum . 1987;30:1196-1197.Crossref 14. Olson NY, Lindsley CB, Godfrey WA. Nonsteroidal antiinflammatory drug therapy in chronic childhood iridocyclitis . AJDC. 1988;142:1289-1292. 15. McGill NW, Gow PJ. Juvenile rheumatoid arthritis in Auckland: a long term follow-up study with particular reference to uveitis . Aust N Z J Med . 1987;17:305-308.Crossref 16. Leak AM, Ansell BM, Burman SJ. Antinuclear antibody studies in juvenile chronic arthritis . Arch Dis Child . 1986;61:168-172.Crossref 17. Smiley WK. The eye in juvenile chronic polyarthritis . Clin Rheum Dis . 1976;2:413-428. 18. Petty RE, Hunt DWC, Rollins DF, Schroeder ML, Puterman ML. Immunity to soluble retinal antigen in patients with uveitis accompanying juvenile rheumatoid arthritis . Arthritis Rheum . 1987;30:287-293.Crossref 19. Uusitato RJ, Stjernschantz J, Mahlberg K, et al. Serum antibody level to S-antigen in children with chronic uveitis . Br J Ophthalmol . 1985;69:212-216.Crossref 20. Population Estimate . Office of Financial Management, State of Washington. 21. Markowitz M, Gordis A. Rheumatic Fever. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1972:1-13. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Decreasing Severity of Chronic Uveitis in Children With Pauciarticular Arthritis

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1991.02160090078028
Publisher site
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Abstract

Abstract • We compared the current prevalence and severity of chronic uveitis in children with pauciarticular juvenile rheumatoid arthritis in Seattle, Wash, with that of children with the same condition in the same area in 1975. The prevalence of eye disease decreased from 45% in 1975 to 13% in 1989, and the proportion of patients with severe visual loss decreased from 21% in 1975 to none in 1989. We could not attribute these findings to differences in known risk factors for iritis, such as age, sex, or presence of antinuclear antibodies. There was no difference in the duration of follow-up between the two groups. It is possible that the decline in prevalence of uveitis reflects a referral bias for eye disease in the 1975 population. However, the decrease in disease severity remains unexplained and may represent more effective treatment, earlier surveillance for ocular disease, or a change in the frequency of ocular manifestations of this disease in the 1989 group. (AJDC. 1991;145:1026-1028) References 1. Petty RE, Cassidy JT, Sullivan DB. Clinical correlates of antinuclear antibodies in juvenile rheumatoid arthritis . J Pediatr . 1973;83:386-389.Crossref 2. Schaller JG, Johnson GD, Hulborow EJ, Ansell BM, Smiley WK. The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease) . Arthritis Rheum . 1974;17:409-416.Crossref 3. Rosenberg AM. Uveitis associated with juvenile rheumatoid arthritis . Semin Arthritis Rheum . 1987;16:158-173.Crossref 4. Chylack LT Jr. The ocular manifestations of juvenile rheumatoid arthritis . Arthritis Rheum . 1977;20:217-223. 5. Calabro JJ, Parrino R, Atchoo PD, Marchesano JM, Goldberg LS. Chronic iridocyclitis in juvenile rheumatoid arthritis . Arthritis Rheum . 1970;13:406-413.Crossref 6. Wolf MD, Lichter PR, Ragsdale CG. Prognostic factors in the uveitis of juvenile rheumatoid arthritis . Ophthalmology. 1987;94:1242-1248.Crossref 7. Schaller JG, Kupfer C, Wedgwood RJ. Iridocyclitis in juvenile rheumatoid arthritis . Pediatrics. 1969;44:92-100. 8. Schaller JG. Juvenile rheumatoid arthritis: series 1 . Arthritis Rheum . 1977;20:165-170.Crossref 9. Cassidy JT, Sullivan DB, Petty RE. Clinical patterns of chronic iridocyclitis in children with juvenile rheumatoid arthritis . Arthritis Rheum . 1977;20:224-226. 10. Fink CW. Patients with juvenile rheumatoid arthritis: a clinical study . Arthritis Rheum . 1977;20:183-184. 11. Brewer EJ, Bass J, Baum J, et al. Current proposed revision of JRA criteria . Arthritis Rheum . 1977;20:195-199. 12. Rosenberg AM, Oen KG. The relationship between ocular and articular disease activity in children with juvenile rheumatoid arthritis and associated uveitis . Arthritis Rheum . 1986;29:797-800.Crossref 13. Leak AM, Ansell BM. The relationship between ocular and articular disease activity in juvenile rheumatoid arthritis complicated by chronic anterior uveitis . Arthritis Rheum . 1987;30:1196-1197.Crossref 14. Olson NY, Lindsley CB, Godfrey WA. Nonsteroidal antiinflammatory drug therapy in chronic childhood iridocyclitis . AJDC. 1988;142:1289-1292. 15. McGill NW, Gow PJ. Juvenile rheumatoid arthritis in Auckland: a long term follow-up study with particular reference to uveitis . Aust N Z J Med . 1987;17:305-308.Crossref 16. Leak AM, Ansell BM, Burman SJ. Antinuclear antibody studies in juvenile chronic arthritis . Arch Dis Child . 1986;61:168-172.Crossref 17. Smiley WK. The eye in juvenile chronic polyarthritis . Clin Rheum Dis . 1976;2:413-428. 18. Petty RE, Hunt DWC, Rollins DF, Schroeder ML, Puterman ML. Immunity to soluble retinal antigen in patients with uveitis accompanying juvenile rheumatoid arthritis . Arthritis Rheum . 1987;30:287-293.Crossref 19. Uusitato RJ, Stjernschantz J, Mahlberg K, et al. Serum antibody level to S-antigen in children with chronic uveitis . Br J Ophthalmol . 1985;69:212-216.Crossref 20. Population Estimate . Office of Financial Management, State of Washington. 21. Markowitz M, Gordis A. Rheumatic Fever. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1972:1-13.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Sep 1, 1991

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