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Penile Vasculitis With Impending Necrosis Treated With Prostaglandin E1 Infusion

Penile Vasculitis With Impending Necrosis Treated With Prostaglandin E1 Infusion Abstract Sir.—Prostaglandin E1 (PGE1) infusions have been used in the treatment of occlusive vascular diseases since 1973, when Carlson and Eriksson1 described subjective improvement in three of four patients with peripheral atherosclerotic vascular disease and ischemic rest pain given PGE1 by femoral artery infusion. Since that time, PGE1 has been reported to be effective in Raynaud's syndrome, peripheral vascular occlusive disease, and Kawasaki's disease.2-4 We report the dramatic clinical reversal of severe, apparently immune complex-mediated vasculitis of the penis following the use of intravenous PGE1 in an 8-year-old boy. Patient Report.—An 8-year-old black boy presented to the UCLA Medical Center in 1981 with a 1-day history of severe pain and swelling of his penile shaft. He had no other somatic complaints, gave no history of recent febrile illness, and was able to void without difficulty on admission. The patient had a complex References 1. Carlson LA, Eriksson I. Femoralartery infusion of prostaglandin E1 in severe peripheral vascular disease . Lancet . 1973;1:155-156.Crossref 2. Kyle V, Parr G, Salisbury R, Page TP, Hazleman B. Prostaglandin E1 vasospastic disease and thermography . Ann Rheum Dis. 1985;44:73-78.Crossref 3. Trubestein G, Diehm C, Gruss JD, Horsch S. Prostaglandin E1 in chronic arterial disease: a multicenter study . Vasa . 1987;17( (suppl) ):39-43. 4. Wilstphalen MA, McGrath A, Kelly W, Moore FJ, Ziegler JB. Kawasaki disease with severe peripheral ischemia: treatment with prostaglandin E1 infusion . J Pediatr. 1988;112:431-433.Crossref 5. Armitage JM, Hardesty RL, Griffith BP. Prostaglandin E1: an effective treatment of right heart failure after orthotopic heart transplantation . J Heart Transplant . 1987;6:348-351. 6. McLeish ER, Stelzer GT, Eades DS, Cohen R, Wallace JH. Serial changes in humoral and cellular immunity induced by prostaglandin E1 treatment of murine immune complex gromerulonephritis . J Lab Clin Med. 1985;106:517-523. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Penile Vasculitis With Impending Necrosis Treated With Prostaglandin E1 Infusion

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Penile Vasculitis With Impending Necrosis Treated With Prostaglandin E1 Infusion

Abstract

Abstract Sir.—Prostaglandin E1 (PGE1) infusions have been used in the treatment of occlusive vascular diseases since 1973, when Carlson and Eriksson1 described subjective improvement in three of four patients with peripheral atherosclerotic vascular disease and ischemic rest pain given PGE1 by femoral artery infusion. Since that time, PGE1 has been reported to be effective in Raynaud's syndrome, peripheral vascular occlusive disease, and Kawasaki's disease.2-4 We report the...
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1991.02160060020012
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—Prostaglandin E1 (PGE1) infusions have been used in the treatment of occlusive vascular diseases since 1973, when Carlson and Eriksson1 described subjective improvement in three of four patients with peripheral atherosclerotic vascular disease and ischemic rest pain given PGE1 by femoral artery infusion. Since that time, PGE1 has been reported to be effective in Raynaud's syndrome, peripheral vascular occlusive disease, and Kawasaki's disease.2-4 We report the dramatic clinical reversal of severe, apparently immune complex-mediated vasculitis of the penis following the use of intravenous PGE1 in an 8-year-old boy. Patient Report.—An 8-year-old black boy presented to the UCLA Medical Center in 1981 with a 1-day history of severe pain and swelling of his penile shaft. He had no other somatic complaints, gave no history of recent febrile illness, and was able to void without difficulty on admission. The patient had a complex References 1. Carlson LA, Eriksson I. Femoralartery infusion of prostaglandin E1 in severe peripheral vascular disease . Lancet . 1973;1:155-156.Crossref 2. Kyle V, Parr G, Salisbury R, Page TP, Hazleman B. Prostaglandin E1 vasospastic disease and thermography . Ann Rheum Dis. 1985;44:73-78.Crossref 3. Trubestein G, Diehm C, Gruss JD, Horsch S. Prostaglandin E1 in chronic arterial disease: a multicenter study . Vasa . 1987;17( (suppl) ):39-43. 4. Wilstphalen MA, McGrath A, Kelly W, Moore FJ, Ziegler JB. Kawasaki disease with severe peripheral ischemia: treatment with prostaglandin E1 infusion . J Pediatr. 1988;112:431-433.Crossref 5. Armitage JM, Hardesty RL, Griffith BP. Prostaglandin E1: an effective treatment of right heart failure after orthotopic heart transplantation . J Heart Transplant . 1987;6:348-351. 6. McLeish ER, Stelzer GT, Eades DS, Cohen R, Wallace JH. Serial changes in humoral and cellular immunity induced by prostaglandin E1 treatment of murine immune complex gromerulonephritis . J Lab Clin Med. 1985;106:517-523.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1991

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