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Growth Response of Growth Hormone-Deficient Patients to 0.06 mg/kg Compared With 0.10 mg/kg Three Times per Week of Biosynthetic Growth Hormone

Growth Response of Growth Hormone-Deficient Patients to 0.06 mg/kg Compared With 0.10 mg/kg Three... Abstract Sir.—The optimal dosage of growth hormone (GH) for the treatment of GH deficiency has not been determined. As little as 2.5 U given once weekly can result in catch-up growth.1 Raben2 established a dosage of 2 U three times per week regardless of body size as the standard that was used into the 1980s. In a series of reports the US Collaborative Study Group concluded that a dosage of 0.06 U/kg of body weight three times per week was appropriate. These and other studies were summarized by Frasier3 in a comprehensive review. He developed a log-dose response curve, based on the published data, that had a very shallow slope, indicating a decreasing cost benefit of increasing dosage. The purpose of this study was to compare what had been a relatively high dosage of pituitary extract GH (0.12 U or 0.06 mg/kg three times per week) recommended by one manufacturer References 1. Rosenbloom AL. Growth hormone replacement therapy . JAMA . 1966;198:364-368.Crossref 2. Raben MS. Growth hormone . N Engl J Med . 1962;266:82-86, 231-235.Crossref 3. Frasier SD. Human pituitary growth hormone (hGH) therapy in growth hormone deficiency . Endocr Rev . 1983;4:155-170.Crossref 4. Rosenbloom AL, Knuth C, Shulman D. Optimal dosage interval for biosynthetic GH replacement (Somatrem) in GH deficiency . Pediatr Res . 1988;23:285. Abstract. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Growth Response of Growth Hormone-Deficient Patients to 0.06 mg/kg Compared With 0.10 mg/kg Three Times per Week of Biosynthetic Growth Hormone

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1989.02150180020008
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—The optimal dosage of growth hormone (GH) for the treatment of GH deficiency has not been determined. As little as 2.5 U given once weekly can result in catch-up growth.1 Raben2 established a dosage of 2 U three times per week regardless of body size as the standard that was used into the 1980s. In a series of reports the US Collaborative Study Group concluded that a dosage of 0.06 U/kg of body weight three times per week was appropriate. These and other studies were summarized by Frasier3 in a comprehensive review. He developed a log-dose response curve, based on the published data, that had a very shallow slope, indicating a decreasing cost benefit of increasing dosage. The purpose of this study was to compare what had been a relatively high dosage of pituitary extract GH (0.12 U or 0.06 mg/kg three times per week) recommended by one manufacturer References 1. Rosenbloom AL. Growth hormone replacement therapy . JAMA . 1966;198:364-368.Crossref 2. Raben MS. Growth hormone . N Engl J Med . 1962;266:82-86, 231-235.Crossref 3. Frasier SD. Human pituitary growth hormone (hGH) therapy in growth hormone deficiency . Endocr Rev . 1983;4:155-170.Crossref 4. Rosenbloom AL, Knuth C, Shulman D. Optimal dosage interval for biosynthetic GH replacement (Somatrem) in GH deficiency . Pediatr Res . 1988;23:285. Abstract.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1989

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