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Phenobarbital Increases Aminophylline Requirement in Premature Infants

Phenobarbital Increases Aminophylline Requirement in Premature Infants Abstract Sir.—We read with interest the study by Yazdani et al1 on the increased theophylline requirements for the control of apnea in premature infants who are also receiving phenobarbital for seizure control. Unfortunately, their retrospective study did not include infants' serum theophylline levels before and after institution of phenobarbital therapy. Patient Report.—Starting on the second day of life, we administered aminophylline for the treatment of apnea to a 640-g (birth weight) infant who was of 24 weeks' gestation. Minimal ventilatory support was subsequently necessary. A therapeutic serum theophylline level of 9.4 mg/L (52 μmol/L) was achieved with a 5.5-mg/kg loading dose of aminophylline (theophylline ethylene diamine), followed by a maintenance dosage of 2.0 mg/kg/24 h, administered intravenously. On the fourth day of life, phenobarbital sodium, in a loading dose of 20 mg/kg, was administered intravenously following seizure activity. Cranial ultrasonography disclosed a grade 2 intracranial hemorrhage. The seizures References 1. Yazdani M, Kissling GE, Tran TH, et al: Phenobarbital increases the theophylline requirement of premature infants being treated for apnea . AJDC 1987;141:97-99. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Phenobarbital Increases Aminophylline Requirement in Premature Infants

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1988.02150020016006
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—We read with interest the study by Yazdani et al1 on the increased theophylline requirements for the control of apnea in premature infants who are also receiving phenobarbital for seizure control. Unfortunately, their retrospective study did not include infants' serum theophylline levels before and after institution of phenobarbital therapy. Patient Report.—Starting on the second day of life, we administered aminophylline for the treatment of apnea to a 640-g (birth weight) infant who was of 24 weeks' gestation. Minimal ventilatory support was subsequently necessary. A therapeutic serum theophylline level of 9.4 mg/L (52 μmol/L) was achieved with a 5.5-mg/kg loading dose of aminophylline (theophylline ethylene diamine), followed by a maintenance dosage of 2.0 mg/kg/24 h, administered intravenously. On the fourth day of life, phenobarbital sodium, in a loading dose of 20 mg/kg, was administered intravenously following seizure activity. Cranial ultrasonography disclosed a grade 2 intracranial hemorrhage. The seizures References 1. Yazdani M, Kissling GE, Tran TH, et al: Phenobarbital increases the theophylline requirement of premature infants being treated for apnea . AJDC 1987;141:97-99.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Feb 1, 1988

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