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Anaphylactic Shock due to Cytarabine in a Leukemic Child

Anaphylactic Shock due to Cytarabine in a Leukemic Child Abstract • In a young child with acute promyelocytic leukemia, treatment with a variety of chemotherapeutic agents produced an acute anaphylactic reaction. When cytarabine was removed from the chemotherapeutic regimen, no further anaphylaxis occurred. Employing an enzyme-linked Immunosorbent assay with cytarabine coated onto the wells in bovine serum albumin, specific IgE antibodies to this drug could be demonstrated. Similar antibodies could not be demonstrated in the serum of normal controls or of two other patients receiving cytarabine. We therefore document anaphylactic shock mediated by specific IgE antibodies to cytarabine. (AJDC 1987;141:1000-1001) References 1. Grier HE, Weinstein HJ: Acute nonlymphocytic leukemia . Pediatr Clin North Am 1985;32: 653-668. 2. Bleyer WA: Cancer chemotherapy in infants and children . Pediatr Clin North Am 1985;32: 557-574. 3. Rassiga AL, Schwartz HJ, Forman WB, et al: Cytarabine-induced anaphylaxis: Demonstration of antibody and successful desensitization . Arch Intern Med 1980;140:425-427.Crossref 4. Markman M, Howell SB, King M, et al: Anaphylactic reaction to cytarabine: In vitro evidence that the response is immunoglobulin E mediated . Med Pediatr Oncol 1984;12:201-203.Crossref 5. Jones GR, Ettinger LJ: Continuous infusion of high-dose cytosine arabinoside for treatment of childhood acute leukemia and non-Hodgkin's lymphoma in relapse . Semin Oncol 1985;12( (suppl 3) ):150-154. 6. Weiss RB: Hypersensitivity reactions to cancer chemotherapy . Semin Oncol 1982;9:5-13. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Anaphylactic Shock due to Cytarabine in a Leukemic Child

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460090077031
Publisher site
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Abstract

Abstract • In a young child with acute promyelocytic leukemia, treatment with a variety of chemotherapeutic agents produced an acute anaphylactic reaction. When cytarabine was removed from the chemotherapeutic regimen, no further anaphylaxis occurred. Employing an enzyme-linked Immunosorbent assay with cytarabine coated onto the wells in bovine serum albumin, specific IgE antibodies to this drug could be demonstrated. Similar antibodies could not be demonstrated in the serum of normal controls or of two other patients receiving cytarabine. We therefore document anaphylactic shock mediated by specific IgE antibodies to cytarabine. (AJDC 1987;141:1000-1001) References 1. Grier HE, Weinstein HJ: Acute nonlymphocytic leukemia . Pediatr Clin North Am 1985;32: 653-668. 2. Bleyer WA: Cancer chemotherapy in infants and children . Pediatr Clin North Am 1985;32: 557-574. 3. Rassiga AL, Schwartz HJ, Forman WB, et al: Cytarabine-induced anaphylaxis: Demonstration of antibody and successful desensitization . Arch Intern Med 1980;140:425-427.Crossref 4. Markman M, Howell SB, King M, et al: Anaphylactic reaction to cytarabine: In vitro evidence that the response is immunoglobulin E mediated . Med Pediatr Oncol 1984;12:201-203.Crossref 5. Jones GR, Ettinger LJ: Continuous infusion of high-dose cytosine arabinoside for treatment of childhood acute leukemia and non-Hodgkin's lymphoma in relapse . Semin Oncol 1985;12( (suppl 3) ):150-154. 6. Weiss RB: Hypersensitivity reactions to cancer chemotherapy . Semin Oncol 1982;9:5-13.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Sep 1, 1987

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