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Is Cardiac Transplantation in Children an Experimental Procedure?

Is Cardiac Transplantation in Children an Experimental Procedure? Abstract Since Dr Christiaan Barnard's first cardiac transplant in a human adult, cardiac transplantation has become an almost commonplace and accepted procedure with every expectation for long-term success, with a one-year survival rate of 80%,1 a three-year survival rate of 72%, and a five-year survival rate of 50%. These survival rates are expected to improve based on the three-year data collected since the use of cyclosporine began (actuarial data from Jack G. Copeland, MD, oral communication, July 1986). The most common indication for cardiac replacement in adults is congestive cardiomyopathy from myocarditis or end-stage coronary artery disease. The greatest management problem is immunologic rejection of the transplanted heart, which is now managed much more easily in conjunction with corticosteroids since the drug cyclosporine has become available.2 Translation of the adult experience to the pediatric patient has not been direct for many reasons. First, children have seldom been in a References 1. Griffith BP, Hardesty RL, Deeb GM, et al: Cardiac transplantation with cyclosporin A and prednisone . Ann Surg 1981;196:324-329.Crossref 2. Copeland JG, Emery RW, Levinson M, et al: Cyclosporine: An immunosuppressive panacea? J Thorac Cardiovasc Surg 1986;91:26-39. 3. Cutilletta AF, O'Connell JB, Nordin MR, et al: Myocardial growth after heart transplantation in children . Pediatr Res 1986;20:169A.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Is Cardiac Transplantation in Children an Experimental Procedure?

American Journal of Diseases of Children , Volume 140 (11) – Nov 1, 1986

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140250031028
Publisher site
See Article on Publisher Site

Abstract

Abstract Since Dr Christiaan Barnard's first cardiac transplant in a human adult, cardiac transplantation has become an almost commonplace and accepted procedure with every expectation for long-term success, with a one-year survival rate of 80%,1 a three-year survival rate of 72%, and a five-year survival rate of 50%. These survival rates are expected to improve based on the three-year data collected since the use of cyclosporine began (actuarial data from Jack G. Copeland, MD, oral communication, July 1986). The most common indication for cardiac replacement in adults is congestive cardiomyopathy from myocarditis or end-stage coronary artery disease. The greatest management problem is immunologic rejection of the transplanted heart, which is now managed much more easily in conjunction with corticosteroids since the drug cyclosporine has become available.2 Translation of the adult experience to the pediatric patient has not been direct for many reasons. First, children have seldom been in a References 1. Griffith BP, Hardesty RL, Deeb GM, et al: Cardiac transplantation with cyclosporin A and prednisone . Ann Surg 1981;196:324-329.Crossref 2. Copeland JG, Emery RW, Levinson M, et al: Cyclosporine: An immunosuppressive panacea? J Thorac Cardiovasc Surg 1986;91:26-39. 3. Cutilletta AF, O'Connell JB, Nordin MR, et al: Myocardial growth after heart transplantation in children . Pediatr Res 1986;20:169A.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1986

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