Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Vancomycin Pharmacokinetics in Neonates-Reply

Vancomycin Pharmacokinetics in Neonates-Reply Abstract In Reply.—We agree with Mr Spivey and Dr Gal regarding vancomycin pharmacokinetics in neonates who receive indomethacin therapy. The decline in glomerular filtration rate (GFR) that occurs with indomethacin administration has been found to be reversible in most cases,1 with diuresis over the one to two days immediately following discontinuation of the drug. This decline is followed by normalization of GFR and subsequent age-related increase in GFR over the next one to two weeks. Four patients in our study received indomethacin therapy that had been discontinued two to four weeks prior to the vancomycin pharmacokinetic study. Because of the time that had elapsed since the administration of indomethacin, we did not regard it as a significant variable in our patients. However, the observations of Spivey and Gal reemphasize the importance of individualized dosing schedules, particularly for complicated patients. References 1. Cifuentes RF, Olley PM, Balfe JW, et al: Indomethacin and renal function in premature infants with persistent patent ductus arteriosus . J Pediatr 1979;95:583-587.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Vancomycin Pharmacokinetics in Neonates-Reply

Download PDF
1 page

Vancomycin Pharmacokinetics in Neonates-Reply

Abstract

Abstract In Reply.—We agree with Mr Spivey and Dr Gal regarding vancomycin pharmacokinetics in neonates who receive indomethacin therapy. The decline in glomerular filtration rate (GFR) that occurs with indomethacin administration has been found to be reversible in most cases,1 with diuresis over the one to two days immediately following discontinuation of the drug. This decline is followed by normalization of GFR and subsequent age-related increase in GFR over the next one to two...
Loading next page...
 
/lp/american-medical-association/vancomycin-pharmacokinetics-in-neonates-reply-LDZZxsYWbb

References (1)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140230029021
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply.—We agree with Mr Spivey and Dr Gal regarding vancomycin pharmacokinetics in neonates who receive indomethacin therapy. The decline in glomerular filtration rate (GFR) that occurs with indomethacin administration has been found to be reversible in most cases,1 with diuresis over the one to two days immediately following discontinuation of the drug. This decline is followed by normalization of GFR and subsequent age-related increase in GFR over the next one to two weeks. Four patients in our study received indomethacin therapy that had been discontinued two to four weeks prior to the vancomycin pharmacokinetic study. Because of the time that had elapsed since the administration of indomethacin, we did not regard it as a significant variable in our patients. However, the observations of Spivey and Gal reemphasize the importance of individualized dosing schedules, particularly for complicated patients. References 1. Cifuentes RF, Olley PM, Balfe JW, et al: Indomethacin and renal function in premature infants with persistent patent ductus arteriosus . J Pediatr 1979;95:583-587.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Sep 1, 1986

There are no references for this article.