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Study of Thymic Hormone Therapy for Histiocytosis X

Study of Thymic Hormone Therapy for Histiocytosis X Abstract Sir.—The optimal treatment of patients with histiocytosis X remains uncertain. Preliminary clinical studies1-6 have demonstrated that a thymic hormone preparation may be a useful therapy for this disease. The Food and Drug Administration is sponsoring a clinical trial of Suppressin A, one such thymic hormone drug. The purpose of this prospective, randomized, double-blind, placebo-controlled study is to determine if Suppressin A is biologically active in histiocytosis X. I am the principal investigator of this study and am writing to you at this time to solicit patient referrals. The study includes both children and adults with histiocytosis X and patients can be either newly diagnosed or recently relapsed. Please write or call me collect ([617] 638-4182) for further information. Thank you very much for your cooperation in this regard. References 1. Osband ME, Lipton MD, Lavin P, et al: Demonstration of abnormal immunity, T-cell histamine H2-receptor deficiency, and successful treatment with thymic extract . N Engl J Med 1981;304:146-153.Crossref 2. Osband ME, Lipton JM: Histiocytosis-X , in Gellis SS, Kagan BM (eds): Current Pediatric Therapy . Philadelphia, WB Saunders Co, 1980, pp 704-705. 3. Osband ME, Cohen EB, Shipman DL: Treatment of histiocytosis-X with suppressin , in Byrom NA, Hobbs JR (eds): Thymic Factor Therapy . New York, Academic Press Inc, 1984, pp 391-398. 4. Davies EG, Levinsky RJ, Butler M, et al: Thymic hormone therapy for histiocytosis-X? N Engl J Med 1983;309:493-494. 5. Osband ME: Histiocytosis-X , in Current Therapy in Hematology-Oncology 1985-1986 . Philadelphia, BC Decker Inc, 1985, pp 94-98. 6. Eckstein R, Huhn D, Schneider B, et al: Influence on immune function parameters in histiocytosis-X of thymostimulin . Arzneimittelforsch 1985;35:155-162. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Study of Thymic Hormone Therapy for Histiocytosis X

Study of Thymic Hormone Therapy for Histiocytosis X

Abstract

Abstract Sir.—The optimal treatment of patients with histiocytosis X remains uncertain. Preliminary clinical studies1-6 have demonstrated that a thymic hormone preparation may be a useful therapy for this disease. The Food and Drug Administration is sponsoring a clinical trial of Suppressin A, one such thymic hormone drug. The purpose of this prospective, randomized, double-blind, placebo-controlled study is to determine if Suppressin A is biologically active in histiocytosis X. I am...
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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140170017014
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—The optimal treatment of patients with histiocytosis X remains uncertain. Preliminary clinical studies1-6 have demonstrated that a thymic hormone preparation may be a useful therapy for this disease. The Food and Drug Administration is sponsoring a clinical trial of Suppressin A, one such thymic hormone drug. The purpose of this prospective, randomized, double-blind, placebo-controlled study is to determine if Suppressin A is biologically active in histiocytosis X. I am the principal investigator of this study and am writing to you at this time to solicit patient referrals. The study includes both children and adults with histiocytosis X and patients can be either newly diagnosed or recently relapsed. Please write or call me collect ([617] 638-4182) for further information. Thank you very much for your cooperation in this regard. References 1. Osband ME, Lipton MD, Lavin P, et al: Demonstration of abnormal immunity, T-cell histamine H2-receptor deficiency, and successful treatment with thymic extract . N Engl J Med 1981;304:146-153.Crossref 2. Osband ME, Lipton JM: Histiocytosis-X , in Gellis SS, Kagan BM (eds): Current Pediatric Therapy . Philadelphia, WB Saunders Co, 1980, pp 704-705. 3. Osband ME, Cohen EB, Shipman DL: Treatment of histiocytosis-X with suppressin , in Byrom NA, Hobbs JR (eds): Thymic Factor Therapy . New York, Academic Press Inc, 1984, pp 391-398. 4. Davies EG, Levinsky RJ, Butler M, et al: Thymic hormone therapy for histiocytosis-X? N Engl J Med 1983;309:493-494. 5. Osband ME: Histiocytosis-X , in Current Therapy in Hematology-Oncology 1985-1986 . Philadelphia, BC Decker Inc, 1985, pp 94-98. 6. Eckstein R, Huhn D, Schneider B, et al: Influence on immune function parameters in histiocytosis-X of thymostimulin . Arzneimittelforsch 1985;35:155-162.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1986

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