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Hyperglycemia and Sepsis in a Newborn-Reply

Hyperglycemia and Sepsis in a Newborn-Reply Abstract Dr Kramer is correct in pointing out that hyperglycemia in neonates with sepsis may have multiple etiologic factors. We were unable to measure the possible contributing effects of human growth hormone, hydrocortisone, glucagon, or catecholamines. Cryer et al1 measured these hormones in baboons with Escherichia coli sepsis. They concluded that an inadequate insulin response was sufficient to account for hyperglycemia in sepsis.1 Our patient had serum levels of insulin of 11 μU/mL and 13 μU/mL when her serum concentrations of glucose were 314 mg/dL and 285 mg/dL, respectively. For these glucose levels one would anticipate a greater insulin response.2 Since our patient was apparently incapable of greater insulin production, I must assume that her response was inadequate. However, I do not have the data to indicate if this inadequate response were the result of sepsis or of the immaturity of a 1.3-kg, 1-month-old, preterm infant. References 1. Cryer PE, Herman CM, Sode J: Carbohydrate metabolism in the baboon subjected to Gram-negative (E coli) septicemia . Ann Surg 174:91-100, 1971.Crossref 2. Cornblath M, Schwartz R: Disorders of Carbohydrate Metabolism in Infancy , ed 2. Philadelphia, WB Saunders Co, 1976, pp 95-99. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Hyperglycemia and Sepsis in a Newborn-Reply

American Journal of Diseases of Children , Volume 134 (4) – Apr 1, 1980

Hyperglycemia and Sepsis in a Newborn-Reply

Abstract

Abstract Dr Kramer is correct in pointing out that hyperglycemia in neonates with sepsis may have multiple etiologic factors. We were unable to measure the possible contributing effects of human growth hormone, hydrocortisone, glucagon, or catecholamines. Cryer et al1 measured these hormones in baboons with Escherichia coli sepsis. They concluded that an inadequate insulin response was sufficient to account for hyperglycemia in sepsis.1 Our patient had serum levels of insulin of 11 μU/mL...
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.04490010077026
Publisher site
See Article on Publisher Site

Abstract

Abstract Dr Kramer is correct in pointing out that hyperglycemia in neonates with sepsis may have multiple etiologic factors. We were unable to measure the possible contributing effects of human growth hormone, hydrocortisone, glucagon, or catecholamines. Cryer et al1 measured these hormones in baboons with Escherichia coli sepsis. They concluded that an inadequate insulin response was sufficient to account for hyperglycemia in sepsis.1 Our patient had serum levels of insulin of 11 μU/mL and 13 μU/mL when her serum concentrations of glucose were 314 mg/dL and 285 mg/dL, respectively. For these glucose levels one would anticipate a greater insulin response.2 Since our patient was apparently incapable of greater insulin production, I must assume that her response was inadequate. However, I do not have the data to indicate if this inadequate response were the result of sepsis or of the immaturity of a 1.3-kg, 1-month-old, preterm infant. References 1. Cryer PE, Herman CM, Sode J: Carbohydrate metabolism in the baboon subjected to Gram-negative (E coli) septicemia . Ann Surg 174:91-100, 1971.Crossref 2. Cornblath M, Schwartz R: Disorders of Carbohydrate Metabolism in Infancy , ed 2. Philadelphia, WB Saunders Co, 1976, pp 95-99.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1980

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