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Asymptomatic Familial Elevation of Serum Alkaline Phosphatase Levels

Asymptomatic Familial Elevation of Serum Alkaline Phosphatase Levels Abstract Asymptomatic elevation of serum alkaline phosphatase levels has been reported recently in one family. An autosomal dominant inheritance was suggested by father-son transmission.1 Both liver and bone isoenzyme levels were elevated. We describe another family that had elevations of serum alkaline phosphatase levels without apparent disease. In this family, the heat labile fraction (representing the bone isoenzyme level) was greater than 90% in all affected individuals. Report of a Case.—An 11-year-old asymptomatic girl was found to have an elevated serum alkaline phoshatase level after the incidental discovery of an increased level in her mother. Extensive investigations failed to reveal a cause for the elevated level in the mother. Results of a physical examination of the daughter were entirely normal. Results of laboratory studies, including complete blood cell count, urinalysis, and serum chemistries, were normal except for a fasting serum alkaline phosphatase level of 664 IU/L (normal, 40 to 110 References 1. Wilson JW: Inherited elevation of alkaline phosphatase activity in the absence of disease . N Engl J Med 301:983-984, 1979.Crossref 2. Wolf PL: Clinical significance of an increased or decreased serum alkaline phosphatase level . Arch Pathol Lab Med 102:497-501, 1978. 3. Kaplan MK: Alkaline phosphatase . Gastroenterology 62:452-468, 1972. 4. Stolbach LL: Ectopic production on an alkaline phosphatase isoenzyme in patients with cancer . N Engl J Med 281:757-762, 1969.Crossref 5. Cleeve HJW: Origin of an elevated plasma alkaline phosphatase activity in non-jaundiced patients . Ann Clin Biochem 15:86-90, 1978.Crossref 6. Davidson FD: Use of the albumin/globulin ratio in differentiation between bone and liver isoenzymes of alkaline phosphatase . Clin Chem 24:2214-2215, 1978. 7. Hamilton DV, Potasman I: Thyroid disease and alkaline phosphatase . Ann Intern Med 90:440-441, 1979.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Asymptomatic Familial Elevation of Serum Alkaline Phosphatase Levels

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130230072022
Publisher site
See Article on Publisher Site

Abstract

Abstract Asymptomatic elevation of serum alkaline phosphatase levels has been reported recently in one family. An autosomal dominant inheritance was suggested by father-son transmission.1 Both liver and bone isoenzyme levels were elevated. We describe another family that had elevations of serum alkaline phosphatase levels without apparent disease. In this family, the heat labile fraction (representing the bone isoenzyme level) was greater than 90% in all affected individuals. Report of a Case.—An 11-year-old asymptomatic girl was found to have an elevated serum alkaline phoshatase level after the incidental discovery of an increased level in her mother. Extensive investigations failed to reveal a cause for the elevated level in the mother. Results of a physical examination of the daughter were entirely normal. Results of laboratory studies, including complete blood cell count, urinalysis, and serum chemistries, were normal except for a fasting serum alkaline phosphatase level of 664 IU/L (normal, 40 to 110 References 1. Wilson JW: Inherited elevation of alkaline phosphatase activity in the absence of disease . N Engl J Med 301:983-984, 1979.Crossref 2. Wolf PL: Clinical significance of an increased or decreased serum alkaline phosphatase level . Arch Pathol Lab Med 102:497-501, 1978. 3. Kaplan MK: Alkaline phosphatase . Gastroenterology 62:452-468, 1972. 4. Stolbach LL: Ectopic production on an alkaline phosphatase isoenzyme in patients with cancer . N Engl J Med 281:757-762, 1969.Crossref 5. Cleeve HJW: Origin of an elevated plasma alkaline phosphatase activity in non-jaundiced patients . Ann Clin Biochem 15:86-90, 1978.Crossref 6. Davidson FD: Use of the albumin/globulin ratio in differentiation between bone and liver isoenzymes of alkaline phosphatase . Clin Chem 24:2214-2215, 1978. 7. Hamilton DV, Potasman I: Thyroid disease and alkaline phosphatase . Ann Intern Med 90:440-441, 1979.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1980

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