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Local Immunity in Mumps Meningitis

Local Immunity in Mumps Meningitis Abstract • Titers of antibodies to mumps and measles virus and interferon activity were measured in sera and CSF obtained from 15 children with mumps meningitis. Antibody to mumps virus was found in 11 of 15 CSF samples. Evaluation of the CSF-serum ratio for antibodies to both viruses showed a substantially higher ratio for antibody to mumps virus. The ratio of IgG/IgM antibody activity to mumps virus was greater in CSF than in sera. These results could be attributed to antibody synthesis, particularly IgG, in the CNS. Titers of antibodies to mumps virus in CSF increased rapidly, reaching a peak four to ten days from onset of meningitis, and swiftly decreased thereafter. During the acute phase, interferon activity was found in almost all cases ranging from 16 to 128 IU/mL in sera, and 4 to 16 IU/mL in CSF. In cases of mumps meningitis that followed the usual clinical course, interferon disappeared within a week, whereas it persisted in the CSF in cases of persistent pleocytosis. (Am J Dis Child 134:1060-1064, 1980) References 1. Fenner FJ, White DO: Medical Virology , ed 2. New York, Academic Press Inc, 1976, pp 461-466. 2. Barkin RM: Measles mortality: A retrospective look at the vaccine era . Am J Epidemiol 102:341-349, 1975. 3. Lipton HL, Gonzalez-Scrano F: Central nervous system immunity infected with Theiler's virus: I. Local neutralizing antibody response . J Infect Dis 137:147-151, 1978.Crossref 4. Hapel A, Gardner I: Appearance of cytotoxic T cells in cerebrospinal fluid of mice with ectromelia virus-induced meningitis . Scand J Immunol 3:311-319, 1974.Crossref 5. Ogra PL, Ogra SS, Al-Nakeeb S, et al: Local antibody response to experimental poliovirus infection in the central nervous system of rhesus monkeys . Infect Immun 8:931-937, 1973. 6. Metha P, Kane A, Thormar H: Quantitation of measles virus-specific immunoglobulins in serum, CSF and brain extract from patients with subacute sclerosing panencephalitis . J Immunol 118:2254-2261, 1977. 7. Ogra PL: Distribution of echovirus antibody in serum, nasopharynx, rectum, and spinal fluid after natural infection with echovirus type 6 . Infect Immun 2:150-155, 1970. 8. Rosen L: Hemagglutination and hemagglutination-inhibition with measles virus . Virology 13:139-141, 1961.Crossref 9. Morishima T, Ichikawa T, Yamaguchi H, et al: Acute infantile gastroenteritis caused by rotavirus in Japan . Eur J Pediatr 129:259-265, 1978.Crossref 10. Fogh J, Lund R: Continuous cultivation of epithelial cell strain (FL) from human amniotic membrane . Proc Soc Exp Biol Med 94:532-537, 1957.Crossref 11. Havell EA, Vilček J: Production of high-titered interferon in cultures of human diploid cells . Antimicrob Agents Chemother 2:476-484, 1972.Crossref 12. Earle WR, Schilling EL, Stark TH, et al: Production of malignancy in vitro: IV. The mouse fibroblast cultures and changes seen in the living cells . J Natl Cancer Inst 4:165-212, 1943. 13. Whitley RJ, Soong SJ, Dolin R, et al: Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis . N Engl J Med 297:289-294, 1977.Crossref 14. Morishima T, Hayashi K: Meningeal exudate cells in vaccinia meningitis of mice: Role of local T cells . Infect Immun 20:752-759, 1978. 15. Gerhard W, Iwasaki Y, Koprowski H: Central nervous system-associated immune response to parainfluenza type 2 virus in mice . J Immunol 120:1256-1260, 1978. 16. Frydén A, Link H, Moller E: Demonstration of cerebrospinal fluid lymphocytes sensitized against virus antigens in mumps meningitis . Acta Neurol Scand 57:396-404, 1978.Crossref 17. Frydén A, Link H: Predominance of oligoclonal IgG type lambda in CSF in aseptic meningitis . Arch Neurol 36:478-480, 1979.Crossref 18. Gresser I, Naficy K: Recovery of an interferon-like substance from cerebrospinal fluid . Proc Soc Exp Biol Med 117:285-289, 1964.Crossref 19. Baron S, Dianzani F: General considerations of the interferon system . Tex Rep Biol Med 35:1-10, 1977. 20. Youngner JS, Salvin SB: Production and properties of migration inhibitory factors and interferon in the circulation of mice with delayed hypersensitivity . J Immunol 111:1914-1922, 1973. 21. Valle MJ, Jordan GW, Haahr S, et al: Characteristics of immune interferon produced by human lymphocyte cultures compared to other human interferons . J Immunol 115:230-233, 1975. 22. Fujibayashi T, Hooks JJ, Notkins AL: Production of interferon by immune lymphocytes exposed to herpes simplex virus-antibody complexes . J Immunol 115:1191-1193, 1975. 23. Hooks JJ, Moutsopoulos HM, Geis SA, et al: Immune interferon in the circulation of patients with autoimmune disease . N Engl J Med 301:5-8, 1979.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Local Immunity in Mumps Meningitis

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130230040012
Publisher site
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Abstract

Abstract • Titers of antibodies to mumps and measles virus and interferon activity were measured in sera and CSF obtained from 15 children with mumps meningitis. Antibody to mumps virus was found in 11 of 15 CSF samples. Evaluation of the CSF-serum ratio for antibodies to both viruses showed a substantially higher ratio for antibody to mumps virus. The ratio of IgG/IgM antibody activity to mumps virus was greater in CSF than in sera. These results could be attributed to antibody synthesis, particularly IgG, in the CNS. Titers of antibodies to mumps virus in CSF increased rapidly, reaching a peak four to ten days from onset of meningitis, and swiftly decreased thereafter. During the acute phase, interferon activity was found in almost all cases ranging from 16 to 128 IU/mL in sera, and 4 to 16 IU/mL in CSF. In cases of mumps meningitis that followed the usual clinical course, interferon disappeared within a week, whereas it persisted in the CSF in cases of persistent pleocytosis. (Am J Dis Child 134:1060-1064, 1980) References 1. Fenner FJ, White DO: Medical Virology , ed 2. New York, Academic Press Inc, 1976, pp 461-466. 2. Barkin RM: Measles mortality: A retrospective look at the vaccine era . Am J Epidemiol 102:341-349, 1975. 3. Lipton HL, Gonzalez-Scrano F: Central nervous system immunity infected with Theiler's virus: I. Local neutralizing antibody response . J Infect Dis 137:147-151, 1978.Crossref 4. Hapel A, Gardner I: Appearance of cytotoxic T cells in cerebrospinal fluid of mice with ectromelia virus-induced meningitis . Scand J Immunol 3:311-319, 1974.Crossref 5. Ogra PL, Ogra SS, Al-Nakeeb S, et al: Local antibody response to experimental poliovirus infection in the central nervous system of rhesus monkeys . Infect Immun 8:931-937, 1973. 6. Metha P, Kane A, Thormar H: Quantitation of measles virus-specific immunoglobulins in serum, CSF and brain extract from patients with subacute sclerosing panencephalitis . J Immunol 118:2254-2261, 1977. 7. Ogra PL: Distribution of echovirus antibody in serum, nasopharynx, rectum, and spinal fluid after natural infection with echovirus type 6 . Infect Immun 2:150-155, 1970. 8. Rosen L: Hemagglutination and hemagglutination-inhibition with measles virus . Virology 13:139-141, 1961.Crossref 9. Morishima T, Ichikawa T, Yamaguchi H, et al: Acute infantile gastroenteritis caused by rotavirus in Japan . Eur J Pediatr 129:259-265, 1978.Crossref 10. Fogh J, Lund R: Continuous cultivation of epithelial cell strain (FL) from human amniotic membrane . Proc Soc Exp Biol Med 94:532-537, 1957.Crossref 11. Havell EA, Vilček J: Production of high-titered interferon in cultures of human diploid cells . Antimicrob Agents Chemother 2:476-484, 1972.Crossref 12. Earle WR, Schilling EL, Stark TH, et al: Production of malignancy in vitro: IV. The mouse fibroblast cultures and changes seen in the living cells . J Natl Cancer Inst 4:165-212, 1943. 13. Whitley RJ, Soong SJ, Dolin R, et al: Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis . N Engl J Med 297:289-294, 1977.Crossref 14. Morishima T, Hayashi K: Meningeal exudate cells in vaccinia meningitis of mice: Role of local T cells . Infect Immun 20:752-759, 1978. 15. Gerhard W, Iwasaki Y, Koprowski H: Central nervous system-associated immune response to parainfluenza type 2 virus in mice . J Immunol 120:1256-1260, 1978. 16. Frydén A, Link H, Moller E: Demonstration of cerebrospinal fluid lymphocytes sensitized against virus antigens in mumps meningitis . Acta Neurol Scand 57:396-404, 1978.Crossref 17. Frydén A, Link H: Predominance of oligoclonal IgG type lambda in CSF in aseptic meningitis . Arch Neurol 36:478-480, 1979.Crossref 18. Gresser I, Naficy K: Recovery of an interferon-like substance from cerebrospinal fluid . Proc Soc Exp Biol Med 117:285-289, 1964.Crossref 19. Baron S, Dianzani F: General considerations of the interferon system . Tex Rep Biol Med 35:1-10, 1977. 20. Youngner JS, Salvin SB: Production and properties of migration inhibitory factors and interferon in the circulation of mice with delayed hypersensitivity . J Immunol 111:1914-1922, 1973. 21. Valle MJ, Jordan GW, Haahr S, et al: Characteristics of immune interferon produced by human lymphocyte cultures compared to other human interferons . J Immunol 115:230-233, 1975. 22. Fujibayashi T, Hooks JJ, Notkins AL: Production of interferon by immune lymphocytes exposed to herpes simplex virus-antibody complexes . J Immunol 115:1191-1193, 1975. 23. Hooks JJ, Moutsopoulos HM, Geis SA, et al: Immune interferon in the circulation of patients with autoimmune disease . N Engl J Med 301:5-8, 1979.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Nov 1, 1980

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