Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Doxepin Poisoning in a Child

Doxepin Poisoning in a Child Abstract Tricyclic antidepressant drug overdose is an increasingly frequent cause of serious poisoning.1 Imipramine and amitriptyline poisonings have been more commonly reported,2-4 whereas the toxicity of doxepin, a newer drug of this class, is less well described.5 We present a case of severe doxepin hydrochloride poisoning in a child who survived and in whom the diagnosis was made in an unusual and unexpected manner. To our knowledge, no case of doxepin poisoning in a child has been previously reported. Report of a Case.—A 4-year, 6-month-old, 13-kg girl collapsed for no apparent reason after a morning of normal activity and was taken comatose to her local physician. A grand mal seizure ensued that progressed to status epilepticus during her transfer to the University of Kansas Hospital, Kansas City. The history obtained from the parents was negative for metabolic or seizure disorders. The parents did not suspect any drug References 1. Manoguerra AS, Weaver LC: Poisoning with tricyclic antidepressant drugs . Clin Toxicol 10:149-158, 1977.Crossref 2. Goel KM, Shanks RA: Amitriptyline and imipramine poisoning in children . Br Med J 1:261-263, 1974.Crossref 3. Wright SP: Usefulness of physostigmine in imipramine poisoning: A dramatic response in a child resistant to other therapy . Clin Pediatr 15:1123-1128, 1976.Crossref 4. Biggs JT, Spiker DG, Petit JM, et al: Tricyclic antidepressant overdose: Incidence of symptoms . JAMA 238:135-138, 1977.Crossref 5. Janson PA, Watt JB, Hermos JA: Doxepin overdose: Success with physostigmine and failure with neostigmine in reversing toxicity . JAMA 237:2632-2633.Crossref 6. Rumack BH: Anticholinergic poisoning: Treatment with physostigmine . Pediatrics 52:449-451, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Doxepin Poisoning in a Child

Download PDF
2 pages

Loading next page...
 
/lp/american-medical-association/doxepin-poisoning-in-a-child-RceI69rHrG

References (7)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130140072020
Publisher site
See Article on Publisher Site

Abstract

Abstract Tricyclic antidepressant drug overdose is an increasingly frequent cause of serious poisoning.1 Imipramine and amitriptyline poisonings have been more commonly reported,2-4 whereas the toxicity of doxepin, a newer drug of this class, is less well described.5 We present a case of severe doxepin hydrochloride poisoning in a child who survived and in whom the diagnosis was made in an unusual and unexpected manner. To our knowledge, no case of doxepin poisoning in a child has been previously reported. Report of a Case.—A 4-year, 6-month-old, 13-kg girl collapsed for no apparent reason after a morning of normal activity and was taken comatose to her local physician. A grand mal seizure ensued that progressed to status epilepticus during her transfer to the University of Kansas Hospital, Kansas City. The history obtained from the parents was negative for metabolic or seizure disorders. The parents did not suspect any drug References 1. Manoguerra AS, Weaver LC: Poisoning with tricyclic antidepressant drugs . Clin Toxicol 10:149-158, 1977.Crossref 2. Goel KM, Shanks RA: Amitriptyline and imipramine poisoning in children . Br Med J 1:261-263, 1974.Crossref 3. Wright SP: Usefulness of physostigmine in imipramine poisoning: A dramatic response in a child resistant to other therapy . Clin Pediatr 15:1123-1128, 1976.Crossref 4. Biggs JT, Spiker DG, Petit JM, et al: Tricyclic antidepressant overdose: Incidence of symptoms . JAMA 238:135-138, 1977.Crossref 5. Janson PA, Watt JB, Hermos JA: Doxepin overdose: Success with physostigmine and failure with neostigmine in reversing toxicity . JAMA 237:2632-2633.Crossref 6. Rumack BH: Anticholinergic poisoning: Treatment with physostigmine . Pediatrics 52:449-451, 1973.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Feb 1, 1980

There are no references for this article.