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Sensitivity of Group A Streptococci to Antibiotics: Prevalence of Resistance to Erythromycin in Japan

Sensitivity of Group A Streptococci to Antibiotics: Prevalence of Resistance to Erythromycin in... Abstract • More than 60% of all strains of group A streptococci isolated during the period from 1974 to 1975 from children with streptococcal infections in Hokkaido district, Japan, were highly resistant to erythromycin. These strains were found to be multiply resistant to lincomycin hydrochloride monohydrate, chloramphenicol, and tetracycline, and were exclusively type 12 by T-protein typing. The clinical symptoms produced by these organisms were rather mild, responded to penicillin well, and were rarely complicated with glomerulonephritis. The high prevalence of resistant group A streptococci was nationwide, which may have been related to recent excessive use of erythromycin and other macrolide antibiotics. Erythromycin can no longer be considered the drug of choice in the management of streptococcal infections in Japan. This suggests that a periodic surveillance of antibiotic sensitivity of streptococcal isolates may be necessary in other countries in which macrolide antibiotics are frequently prescribed. (Am J Dis Child 133:1143-1145, 1979) References 1. Lowbury EJL: Symposium on epidemiological risks of antibiotics . Proc R Soc Med 51:807-810, 1958. 2. Sanders E, Foster MT, Scott D: Group A β-hemolytic streptococci resistant to erythromycin and lincomycin . N Engl J Med 278:538-540, 1968.Crossref 3. Lowbury EJL, Kidson A: Group A streptococci resistant to lincomycin . Br Med J 2:490-491, 1968.Crossref 4. Dixon JMS: Group A streptococcus resistant to erythromycin and lincomycin . Can Med Assoc J 99:1093-1094, 1968. 5. Drapkin MS, Karchmer AW, Moellering RC Jr: Bacteremic infections due to clindamycin-resistant streptococci . JAMA 236:263-265, 1976.Crossref 6. Vaughan VC, McKay RJ: Nelson Textbook of Pediatrics , ed 10. Philadelphia, WB Saunders Co, 1975, pp 569-573. 7. Krugman S, Ward R, Katz SL: Infectious Disease of Children , ed 6. St Louis, CV Mosby Co, 1977, pp 340-351. 8. Nakae M, Murai T, Kaneko T, et al: Drug resistance in streptococcus pyogenes isolated in Japan . Antimicrob Agents Chemother 12:427-428, 1977.Crossref 9. Miyamoto Y, Takizawa K, Matsushima A, et al: Stepwise acquisition of multiple drug resistance by β-hemolytic streptococci and difference in resistance pattern . Antimicrob Agents Chemother 13:399-404, 1978.Crossref 10. Dixon JMS, Lipinski AE: Resistance of group A β-hemolytic streptococci to lincomycin and erythromycin . Antimicrob Agents Chemother 1:333-339, 1972.Crossref 11. O'Brien TF, Acar JF, Medeiros AA, et al: International comparison of prevalence of resistance to antibiotics . JAMA 239:1518-1523, 1978.Crossref 12. Okubo N, Kashiwagi Y, Shibata M, et al (Scarlet Fever Study Group): Changes in drug resistance of group A streptococci in recent 6 years . Jpn J Infect Dis 47:506-509, 1973. 13. Miyamoto Y, Takizawa K, Asai Y, et al (Scarlet Fever Study Group): Transition of the distribution of types of group A streptococci (from April 1969 to March 1974) and annual change of the main predominant types for the past 10 years . Jpn J Infect Dis 49:86-93, 1975. 14. Shishido H, Sekiguchi H, Numazaki Y, et al: Antibiotic susceptibility in relation to serotype of Streptococcus pyogenes isolated from patients with acute infections at a pediatric outpatient clinic in Sendai . Jpn J Infect Dis 52:364-369, 1978. 15. Fujii R: Present state of antibiotic consumption in Japan . Saishin-igaku 32:1439-1445, 1977. 16. Fujii R: Consumption of antibiotics in Japan . Chemotherapy 25:418-423, 1977. 17. Miyamoto Y, Kodama T, Akiyama S, et al: Type distribution of A group streptococci in April 1968 to March 1969 . Jpn J Infect Dis 44:9-11, 1970. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Sensitivity of Group A Streptococci to Antibiotics: Prevalence of Resistance to Erythromycin in Japan

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References (20)

Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1979.02130110051007
Publisher site
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Abstract

Abstract • More than 60% of all strains of group A streptococci isolated during the period from 1974 to 1975 from children with streptococcal infections in Hokkaido district, Japan, were highly resistant to erythromycin. These strains were found to be multiply resistant to lincomycin hydrochloride monohydrate, chloramphenicol, and tetracycline, and were exclusively type 12 by T-protein typing. The clinical symptoms produced by these organisms were rather mild, responded to penicillin well, and were rarely complicated with glomerulonephritis. The high prevalence of resistant group A streptococci was nationwide, which may have been related to recent excessive use of erythromycin and other macrolide antibiotics. Erythromycin can no longer be considered the drug of choice in the management of streptococcal infections in Japan. This suggests that a periodic surveillance of antibiotic sensitivity of streptococcal isolates may be necessary in other countries in which macrolide antibiotics are frequently prescribed. (Am J Dis Child 133:1143-1145, 1979) References 1. Lowbury EJL: Symposium on epidemiological risks of antibiotics . Proc R Soc Med 51:807-810, 1958. 2. Sanders E, Foster MT, Scott D: Group A β-hemolytic streptococci resistant to erythromycin and lincomycin . N Engl J Med 278:538-540, 1968.Crossref 3. Lowbury EJL, Kidson A: Group A streptococci resistant to lincomycin . Br Med J 2:490-491, 1968.Crossref 4. Dixon JMS: Group A streptococcus resistant to erythromycin and lincomycin . Can Med Assoc J 99:1093-1094, 1968. 5. Drapkin MS, Karchmer AW, Moellering RC Jr: Bacteremic infections due to clindamycin-resistant streptococci . JAMA 236:263-265, 1976.Crossref 6. Vaughan VC, McKay RJ: Nelson Textbook of Pediatrics , ed 10. Philadelphia, WB Saunders Co, 1975, pp 569-573. 7. Krugman S, Ward R, Katz SL: Infectious Disease of Children , ed 6. St Louis, CV Mosby Co, 1977, pp 340-351. 8. Nakae M, Murai T, Kaneko T, et al: Drug resistance in streptococcus pyogenes isolated in Japan . Antimicrob Agents Chemother 12:427-428, 1977.Crossref 9. Miyamoto Y, Takizawa K, Matsushima A, et al: Stepwise acquisition of multiple drug resistance by β-hemolytic streptococci and difference in resistance pattern . Antimicrob Agents Chemother 13:399-404, 1978.Crossref 10. Dixon JMS, Lipinski AE: Resistance of group A β-hemolytic streptococci to lincomycin and erythromycin . Antimicrob Agents Chemother 1:333-339, 1972.Crossref 11. O'Brien TF, Acar JF, Medeiros AA, et al: International comparison of prevalence of resistance to antibiotics . JAMA 239:1518-1523, 1978.Crossref 12. Okubo N, Kashiwagi Y, Shibata M, et al (Scarlet Fever Study Group): Changes in drug resistance of group A streptococci in recent 6 years . Jpn J Infect Dis 47:506-509, 1973. 13. Miyamoto Y, Takizawa K, Asai Y, et al (Scarlet Fever Study Group): Transition of the distribution of types of group A streptococci (from April 1969 to March 1974) and annual change of the main predominant types for the past 10 years . Jpn J Infect Dis 49:86-93, 1975. 14. Shishido H, Sekiguchi H, Numazaki Y, et al: Antibiotic susceptibility in relation to serotype of Streptococcus pyogenes isolated from patients with acute infections at a pediatric outpatient clinic in Sendai . Jpn J Infect Dis 52:364-369, 1978. 15. Fujii R: Present state of antibiotic consumption in Japan . Saishin-igaku 32:1439-1445, 1977. 16. Fujii R: Consumption of antibiotics in Japan . Chemotherapy 25:418-423, 1977. 17. Miyamoto Y, Kodama T, Akiyama S, et al: Type distribution of A group streptococci in April 1968 to March 1969 . Jpn J Infect Dis 44:9-11, 1970.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Nov 1, 1979

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