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M. Lowes (1975)
CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA, PIGMENTARY RETINOPATHY, AND HEART BLOCK (KEARNS‐SAYRE SYNDROME)Acta Ophthalmologica, 53
Walsh FB (1969)
Progressive external opthalmoplegia (PEO): A brief reviewTrans Pa Acad Ophthalmol Otolaryngol, 22
A. Seigel, B. Shaywitz, T. Ciesielski (1977)
Kearns-Sayre syndrome: the importance of early recognition.American journal of diseases of children, 131 6
Michele Toppet, N. Telerman‐Toppet, H. Szliwowski, Marc Vainsel, C. Coërs (1977)
Oculocraniosomatic neuromuscular disease with hypoparathyroidism.American journal of diseases of children, 131 4
Tulgan H Shastri SD (1971)
Progressive ophthalmoplegia, retinitis pigmentosa, and complete heart blockNY State J Med, 71
L. Schneck, M. Adachi, P. Briet, A. Wolintz, B. Volk (1973)
Ophthalmoplegia plus with morphological and chemical studies of cerebellar and muscle tissue.Journal of the neurological sciences, 19 1
Lou HC Reske-Nielsen E (1976)
Progressive external ophthalmoplegiaActa Opthal, 54
J. Haas, P. Haller, U. Patzold (1976)
[Kearns' syndrome (author's transl)].Deutsche medizinische Wochenschrift, 101 42
A. Penn, D. McFarlin (1973)
Session on Neuromuscular DiseasesNeurology, 23
S. Shastri, H. Tulgan, J. Budnitz, J. Colker (1971)
Progressive ophthalmoplegia, retinitis pigmentosa, and complete heart block.New York state journal of medicine, 71 5
Daroff RB Cullen RF (1973)
Early onset external ophthalmoplegia and retinopathy: A distinct clinical and neuropathologic syndromeNeurology, 23
Haller P Haas J (1976)
Das Kearns-SyndromDtsch Med Wochenschr, 101
Abstract Sir.—In their report in the June 1977 issue of the Journal of a patient with Kearns-Sayre syndrome, Seigel et al1 mention diabetes mellitus as a previously undescribed accompaniment of this condition. We have seen three typical cases of Kearns-Sayre syndrome with progressive external ophthalmoplegia, retinal pigmentary degeneration, cardiac conduction defects, small stature, elevated CSF protein, and "ragged-red" fibers in a muscle biopsy specimen. In addition, two of these patients had ataxia, neurosensory hearing loss, and hypogonadism. In a girl, now 17 years old, diabetes mellitus was diagnosed at the age of 13 years. She was treated with diet and insulin. Fasting blood glucose values were also repeatedly elevated (135 to 150 mg/100 ml) in our second case, a young woman aged 21 years. We are aware of six patients2-7 with Kearns-Sayre syndrome and chemical diabetes mellitus (elevated fasting blood glucose or abnormal glucose tolerance test). In addition References 1. Seigel AM, Shaywitz BA, Ciesielski T: Kearns-Sayre syndrome: The importance of early recognition . Am J Dis Child 131:711-712, 1977. 2. Shastri SD, Tulgan H, Colker JL: Progressive ophthalmoplegia, retinitis pigmentosa, and complete heart block . NY State J Med 71:587-590, 1971. 3. Schneck L, Adachi M, Briet P, et al: Ophthalmoplegia plus with morphological and chemical studies of cerebellar and muscle tissue . J Neural Sci 19:37-44, 1973.Crossref 4. Lowes M: Chronic progressive external ophthalmoplegia, pigmentary retinopathy, and heart block (Kearns-Sayre syndrome) . Acta Ophthal 53:610-619, 1975.Crossref 5. Reske-Nielsen E, Lou HC, Lowes H: Progressive external ophthalmoplegia . Acta Opthal 54:553-573, 1976.Crossref 6. Haas J, Haller P, Patzold U: Das Kearns-Syndrom . Dtsch Med Wochenschr 101:1523-1528, 1976.Crossref 7. Toppet M, Telerman-Toppet N, Sliwowski HB, et al: Oculocraniosomatic neuromuscular disease with hypoparathyroidism . Am J Dis Child 131:437-441, 1977. 8. Cullen RF, Daroff RB, Popoff N: Early onset external ophthalmoplegia and retinopathy: A distinct clinical and neuropathologic syndrome . Neurology 23:406, 1973.Crossref 9. Walsh FB: Progressive external opthalmoplegia (PEO): A brief review . Trans Pa Acad Ophthalmol Otolaryngol 22:88-96, 1969.
American Journal of Diseases of Children – American Medical Association
Published: Mar 1, 1978
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