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A Fatal Case of Peliosis of the Liver and Spleen

A Fatal Case of Peliosis of the Liver and Spleen Abstract The condition of diffuse angiomatoid change in the liver known as peliosis hepatis is uncommon, with only eight cases reported in infancy and childhood.1 While the etiology remains obscure, anabolic steroids have recently been implicated in certain instances.2-4 We report a further and most unusual case, in a child with aplastic anemia treated with oxymetholone, in which the peliotic process involved both the liver and spleen. Death was due to the rupture of a peliotic lesion on the surface of the spleen. Of additional interest was the presence of chronic persistent hepatitis demonstrated to be due to hepatitis B antigen. Report of a Case.—This male patient developed idiopathic aplastic anemia at the age of 9 years (June 1970). His initial corticosteroid therapy (prednisone 10 to 60 mg/day) was supplemented with oxymetholone (25 to 100 mg/day) and he received a total of 80 grams over the next five-years. References 1. Nuernberger SP, Ramos CV: Peliosis hepatis in an infant . J Pediatr 87:424-426, 1975.Crossref 2. Naeim F, Cooper PH, Semion AA: Peliosis hepatis, possible etiologic role of anabolic steroids . Arch Pathol 95:284-285, 1973. 3. Groos G, Arnold OM, Brittenger G: Peliosis hepatis after long term administration of oxymetholone . Lancet 1:874, 1974.Crossref 4. Bernstein MS, Hunger RL, Yachuin S: Hepatoma and peliosis hepatis developing in a patient with Fanconi's syndrome . N Engl J Med 284:1135-1136, 1971.Crossref 5. Hamilton FT, Lubitz JM: Peliosis hepatis: Report of three cases with discussion of pathogenesis . Arch Pathol 54:564-572, 1952. 6. Bergs VV, Scotti TM: Virus induced peliosis hepatis in rats . Science 158:377-378, 1967.Crossref 7. Gordon BS, Wolf J, Kranse T, et al: Peliosis hepatis and cholestasis following administration of norethandrolone . Am J Clin Pathol 33:156-165, 1960. 8. Yanoff M, Rawson AJ: Peliosis hepatis: An anatomic study with demonstration of two varieties . Arch Pathol 77:159-165, 1964. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

A Fatal Case of Peliosis of the Liver and Spleen

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120270105023
Publisher site
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Abstract

Abstract The condition of diffuse angiomatoid change in the liver known as peliosis hepatis is uncommon, with only eight cases reported in infancy and childhood.1 While the etiology remains obscure, anabolic steroids have recently been implicated in certain instances.2-4 We report a further and most unusual case, in a child with aplastic anemia treated with oxymetholone, in which the peliotic process involved both the liver and spleen. Death was due to the rupture of a peliotic lesion on the surface of the spleen. Of additional interest was the presence of chronic persistent hepatitis demonstrated to be due to hepatitis B antigen. Report of a Case.—This male patient developed idiopathic aplastic anemia at the age of 9 years (June 1970). His initial corticosteroid therapy (prednisone 10 to 60 mg/day) was supplemented with oxymetholone (25 to 100 mg/day) and he received a total of 80 grams over the next five-years. References 1. Nuernberger SP, Ramos CV: Peliosis hepatis in an infant . J Pediatr 87:424-426, 1975.Crossref 2. Naeim F, Cooper PH, Semion AA: Peliosis hepatis, possible etiologic role of anabolic steroids . Arch Pathol 95:284-285, 1973. 3. Groos G, Arnold OM, Brittenger G: Peliosis hepatis after long term administration of oxymetholone . Lancet 1:874, 1974.Crossref 4. Bernstein MS, Hunger RL, Yachuin S: Hepatoma and peliosis hepatis developing in a patient with Fanconi's syndrome . N Engl J Med 284:1135-1136, 1971.Crossref 5. Hamilton FT, Lubitz JM: Peliosis hepatis: Report of three cases with discussion of pathogenesis . Arch Pathol 54:564-572, 1952. 6. Bergs VV, Scotti TM: Virus induced peliosis hepatis in rats . Science 158:377-378, 1967.Crossref 7. Gordon BS, Wolf J, Kranse T, et al: Peliosis hepatis and cholestasis following administration of norethandrolone . Am J Clin Pathol 33:156-165, 1960. 8. Yanoff M, Rawson AJ: Peliosis hepatis: An anatomic study with demonstration of two varieties . Arch Pathol 77:159-165, 1964.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Feb 1, 1978

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