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Oxolinic Acid Therapy for Urinary Tract Infections in Children

Oxolinic Acid Therapy for Urinary Tract Infections in Children Abstract • Thirty hospitalized children with Gram-negative bacillary urinary tract infections were treated with oxolinic acid for 14 to 21 days. Fifteen of 17 patients with uncomplicated and 11 of 13 with complicated urinary infections had favorable bacteriologic responses. Resistant organisms developed in four treatment failures. Oxolinic acid urine concentrations were well above the minimal inhibitory concentration for most strains of Escherichia coli, Klebsiella, Enterobacter, Proteus mirabilis, P vulgaris, P morganii, and P rettgeri. Approximately half of these patients experienced mild symptoms possibly related to oxolinic acid therapy; in no instance did they require cessation of therapy. Our experience indicates that if the urine is not sterile by the end of five days of treatment, bacterial resistance to oxolinic acid is likely to have developed, and therapy with another agent should be considered and antibiotic susceptibility tests repeated. (Am J Dis Child 131:34-37, 1977) References 1. Edwards PR, Ewing WH: Identification of Enterobacteriaceae , ed 3. Minneapolis, Burgess Publishing Co, 1972. 2. Adler JL, Burke JP, Martin DF, et al: Proteus infections in a general hospital: I Biochemical characterization and antibiotic susceptibility of the organisms . Ann Intern Med 75:517-530, 1971.Crossref 3. Bennett JV, Brodie JL, Brenner EJ, et al: Simplified accurate method for antibiotic assay of clinical specimens . Appl Microbiol 14:170-177, 1966. 4. Turck M, Ronald AR, Petersdorf RG: Relapse and reinfection in chronic bacteruria: II The correlation between site of infection and pattern of recurrence in chronic bacteruria . N Engl J Med 278:422-427, 1969.Crossref 5. Ronald AR, Turck M, Petersdorf RG: A critical evaluation of nalidixic acid in urinary tract infections . N Engl J Med 275:1081-1089, 1966.Crossref 6. Ringel SM, Turner FJ, Lindo FL, et al: Oxolinic acid: A new synthetic antimicrobial agent . Antimicrob Agents Chemother 7:480-485, 1967. 7. Atlas E, Clark H, Silverblatt F, et al: Nalidixic acid and oxolinic acid in the treatment of chronic bacteruria . Ann Intern Med 70:713-721, 1969.Crossref 8. Harrison LH, Cox CE: Bacteriologic and pharmacodynamic aspects of nalidixic acid . J Urol 104:908-913, 1970. 9. Clark H, Brown NK, Wallace JF, et al: Emergence of resistant organisms as a function of oxolinic acid therapy . Am J Med Sci 261:145-148, 1971.Crossref 10. Cox CE: Oxolinic acid therapy of recurrent urinary tract infections . Del Med J 42:327-332, 337, 1970. 11. Blazevic DJ, Stemper JE, Matsen JM: Organisms encountered in urine cultures over a ten-year period . Appl Microbiol 23:421-422, 1972. 12. Madsen PO, Rhodes PR: Oxolinic acid: A new chemotherapeutic agent in the treatment of urinary tract infection . J Invest Urol 105:870-872, 1971. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Oxolinic Acid Therapy for Urinary Tract Infections in Children

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1977.02120140036004
Publisher site
See Article on Publisher Site

Abstract

Abstract • Thirty hospitalized children with Gram-negative bacillary urinary tract infections were treated with oxolinic acid for 14 to 21 days. Fifteen of 17 patients with uncomplicated and 11 of 13 with complicated urinary infections had favorable bacteriologic responses. Resistant organisms developed in four treatment failures. Oxolinic acid urine concentrations were well above the minimal inhibitory concentration for most strains of Escherichia coli, Klebsiella, Enterobacter, Proteus mirabilis, P vulgaris, P morganii, and P rettgeri. Approximately half of these patients experienced mild symptoms possibly related to oxolinic acid therapy; in no instance did they require cessation of therapy. Our experience indicates that if the urine is not sterile by the end of five days of treatment, bacterial resistance to oxolinic acid is likely to have developed, and therapy with another agent should be considered and antibiotic susceptibility tests repeated. (Am J Dis Child 131:34-37, 1977) References 1. Edwards PR, Ewing WH: Identification of Enterobacteriaceae , ed 3. Minneapolis, Burgess Publishing Co, 1972. 2. Adler JL, Burke JP, Martin DF, et al: Proteus infections in a general hospital: I Biochemical characterization and antibiotic susceptibility of the organisms . Ann Intern Med 75:517-530, 1971.Crossref 3. Bennett JV, Brodie JL, Brenner EJ, et al: Simplified accurate method for antibiotic assay of clinical specimens . Appl Microbiol 14:170-177, 1966. 4. Turck M, Ronald AR, Petersdorf RG: Relapse and reinfection in chronic bacteruria: II The correlation between site of infection and pattern of recurrence in chronic bacteruria . N Engl J Med 278:422-427, 1969.Crossref 5. Ronald AR, Turck M, Petersdorf RG: A critical evaluation of nalidixic acid in urinary tract infections . N Engl J Med 275:1081-1089, 1966.Crossref 6. Ringel SM, Turner FJ, Lindo FL, et al: Oxolinic acid: A new synthetic antimicrobial agent . Antimicrob Agents Chemother 7:480-485, 1967. 7. Atlas E, Clark H, Silverblatt F, et al: Nalidixic acid and oxolinic acid in the treatment of chronic bacteruria . Ann Intern Med 70:713-721, 1969.Crossref 8. Harrison LH, Cox CE: Bacteriologic and pharmacodynamic aspects of nalidixic acid . J Urol 104:908-913, 1970. 9. Clark H, Brown NK, Wallace JF, et al: Emergence of resistant organisms as a function of oxolinic acid therapy . Am J Med Sci 261:145-148, 1971.Crossref 10. Cox CE: Oxolinic acid therapy of recurrent urinary tract infections . Del Med J 42:327-332, 337, 1970. 11. Blazevic DJ, Stemper JE, Matsen JM: Organisms encountered in urine cultures over a ten-year period . Appl Microbiol 23:421-422, 1972. 12. Madsen PO, Rhodes PR: Oxolinic acid: A new chemotherapeutic agent in the treatment of urinary tract infection . J Invest Urol 105:870-872, 1971.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1977

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