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Pseudomembranous Colitis Associated With Ampicillin Therapy

Pseudomembranous Colitis Associated With Ampicillin Therapy Abstract Pseudomembranous colitis occurred in a 6½-year-old boy in association with antibiotic therapy. Presumptive diagnosis, based on the characteristic appearance of the rectal mucosa during endoscopy, was supported by pathological examination and negative bacteriologic studies. The illness in this case was self-limited. While the association of this distinctive syndrome with antibiotic therapy has been established, the pathophysiology remains obscure. Clinical recognition of this rare form of colitis is essential to rational management of the illness and future improvement of our understanding of the process. References 1. Goulston SJM, McGovern VJ: Pseudomembranous colitis . GUT 6:207-212, 1965.Crossref 2. Ecker JA, et al: Pseudomembranous enterocolitis—An unwelcome gastrointestinal complication of antibiotic therapy . Am J Gastroenterol 54:214-227, 1970. 3. Schapiro RL, Newman A: Acute enterocolitis: A complication of antibiotic therapy . Radiology 108:263-268, 1973. 4. Bass JW, et al: Ampicillin trihydrate in the treatment of acute otitis media in children . Ann NY Acad Sci 145:379-389, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Pseudomembranous Colitis Associated With Ampicillin Therapy

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1974.02110280099014
Publisher site
See Article on Publisher Site

Abstract

Abstract Pseudomembranous colitis occurred in a 6½-year-old boy in association with antibiotic therapy. Presumptive diagnosis, based on the characteristic appearance of the rectal mucosa during endoscopy, was supported by pathological examination and negative bacteriologic studies. The illness in this case was self-limited. While the association of this distinctive syndrome with antibiotic therapy has been established, the pathophysiology remains obscure. Clinical recognition of this rare form of colitis is essential to rational management of the illness and future improvement of our understanding of the process. References 1. Goulston SJM, McGovern VJ: Pseudomembranous colitis . GUT 6:207-212, 1965.Crossref 2. Ecker JA, et al: Pseudomembranous enterocolitis—An unwelcome gastrointestinal complication of antibiotic therapy . Am J Gastroenterol 54:214-227, 1970. 3. Schapiro RL, Newman A: Acute enterocolitis: A complication of antibiotic therapy . Radiology 108:263-268, 1973. 4. Bass JW, et al: Ampicillin trihydrate in the treatment of acute otitis media in children . Ann NY Acad Sci 145:379-389, 1967.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1974

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