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Carbonic Anhydrase Isoenzymes in Infants With Respiratory Distress Syndrome

Carbonic Anhydrase Isoenzymes in Infants With Respiratory Distress Syndrome Abstract Blood obtained from umbilical cords of 106 preterm infants was analyzed for carbonic anhydrase (CA) activity. Carbonic anhydrase isoenzymes were measured in red blood cells from five adults, eight full-term newborn infants, and 16 premature infants. Carbonic anhydrase activity increased progressively with gestation. Infants with respiratory distress syndrome (RDS) had lower cord blood CA activity than infants without RDS. Carbonic anhydrase B (CA-B), carbonic anhydrase C (CA-C), and total carbonic anhydrase protein (CA-B + CA-C) were highest in adults, then full-term newborns, premature newborns without RDS, and infants with RDS. The ratio of CA-B/CA-C was the same for all newborn groups and lower than the adult ratio. All enzyme activity in newborns could be accounted for by CA-B and CA-C. No inhibitors or abnormal enzymes were present. Importance of findings to RDS pathogenesis is discussed. References 1. Maren TH: Carbonic anhydrase: Chemistry, physiology and inhibition . Physiol Rev 47:595-781, 1967. 2. Stevenson SS: Carbonic anhydrase in newborn infants . J Clin Invest 22:403-409, 1943.Crossref 3. Altschule MD, Smith CA: Blood carbonic anhydrase activity in newborn infants and their mothers . Pediatrics 6:717-720, 1950. 4. Berfenstam R: Studies on carbonic anhydrase activity in children . Acta Paediat Scand 41:32-52, 1952.Crossref 5. Mazzeo G: L'attività carbo-anidrasica nell' immaturo, nel bambino a varie età e suo comportamento in corso di ossigenoterapia . Lattante 30:310-332, 1959. 6. Kleinman LI, Petering HG, Sutherland JM: Blood carbonic anhydrase activity and zinc concentration in infants with respiratory distress syndrome . N Engl J Med 277:1157-1161, 1967.Crossref 7. Tashian RE, Shreffler DC, Shows TB: Genetic and phylogenetic variation in the different molecular forms of mammalian erythrocyte carbonic anhydrases . Ann NY Acad Sci 151:64-77, 1968.Crossref 8. Sell JE: A Biochemical Study of Erythrocyte Carbonic Anhydrase in Neonatal Infants, dissertation submitted to the Division of Graduate Studies, University of Cincinnati, 1971, to be published. 9. Liljestrand G: Chemical control of distribution of pulmonary blood flow . Acta Physiol Scand 44:216-240, 1958.Crossref 10. Chu J, Clements JA, Cotton EK, et al: Neonatal pulmonary ischemia: I. Clinical and physiological studies . Pediatrics 40( (suppl) ):704-782, 1967. 11. Gluck L, Sribney M, Kulovich MV: The biochemical development of surface activity in mammalian lung: II. The biosynthesis of phospholipids in the lung of the developing rabbit fetus and newborn . Pediatr Res 1:247-265, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Carbonic Anhydrase Isoenzymes in Infants With Respiratory Distress Syndrome

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1972.02110170074010
Publisher site
See Article on Publisher Site

Abstract

Abstract Blood obtained from umbilical cords of 106 preterm infants was analyzed for carbonic anhydrase (CA) activity. Carbonic anhydrase isoenzymes were measured in red blood cells from five adults, eight full-term newborn infants, and 16 premature infants. Carbonic anhydrase activity increased progressively with gestation. Infants with respiratory distress syndrome (RDS) had lower cord blood CA activity than infants without RDS. Carbonic anhydrase B (CA-B), carbonic anhydrase C (CA-C), and total carbonic anhydrase protein (CA-B + CA-C) were highest in adults, then full-term newborns, premature newborns without RDS, and infants with RDS. The ratio of CA-B/CA-C was the same for all newborn groups and lower than the adult ratio. All enzyme activity in newborns could be accounted for by CA-B and CA-C. No inhibitors or abnormal enzymes were present. Importance of findings to RDS pathogenesis is discussed. References 1. Maren TH: Carbonic anhydrase: Chemistry, physiology and inhibition . Physiol Rev 47:595-781, 1967. 2. Stevenson SS: Carbonic anhydrase in newborn infants . J Clin Invest 22:403-409, 1943.Crossref 3. Altschule MD, Smith CA: Blood carbonic anhydrase activity in newborn infants and their mothers . Pediatrics 6:717-720, 1950. 4. Berfenstam R: Studies on carbonic anhydrase activity in children . Acta Paediat Scand 41:32-52, 1952.Crossref 5. Mazzeo G: L'attività carbo-anidrasica nell' immaturo, nel bambino a varie età e suo comportamento in corso di ossigenoterapia . Lattante 30:310-332, 1959. 6. Kleinman LI, Petering HG, Sutherland JM: Blood carbonic anhydrase activity and zinc concentration in infants with respiratory distress syndrome . N Engl J Med 277:1157-1161, 1967.Crossref 7. Tashian RE, Shreffler DC, Shows TB: Genetic and phylogenetic variation in the different molecular forms of mammalian erythrocyte carbonic anhydrases . Ann NY Acad Sci 151:64-77, 1968.Crossref 8. Sell JE: A Biochemical Study of Erythrocyte Carbonic Anhydrase in Neonatal Infants, dissertation submitted to the Division of Graduate Studies, University of Cincinnati, 1971, to be published. 9. Liljestrand G: Chemical control of distribution of pulmonary blood flow . Acta Physiol Scand 44:216-240, 1958.Crossref 10. Chu J, Clements JA, Cotton EK, et al: Neonatal pulmonary ischemia: I. Clinical and physiological studies . Pediatrics 40( (suppl) ):704-782, 1967. 11. Gluck L, Sribney M, Kulovich MV: The biochemical development of surface activity in mammalian lung: II. The biosynthesis of phospholipids in the lung of the developing rabbit fetus and newborn . Pediatr Res 1:247-265, 1967.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1972

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