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PNEUMOCOCCAL INFECTIONS IN SICKLE CELL ANEMIA

PNEUMOCOCCAL INFECTIONS IN SICKLE CELL ANEMIA Abstract To the Editor.—This letter is prompted by the article of Seeler et al (Amer J Dis Child 123:8-10, 1972) and by the editorial of Lukens (123:6-7, 1972), both of which express a pessimistic outlook regarding the potential utility of pneumococcal vaccines for the prevention of pneumococcal infections in children with sickle cell anemia. A more optimistic view of prophylactic vaccination seems warranted, perhaps, although extrapolations based upon the small sample reported by Seeler et al must be guarded. Study of pneumococcal infection in large numbers of both children and adults demonstrates clearly that the preponderance of such infections is caused by a limited number of the 82 pneumococcal capsular types, although there are some clear-cut differences in the types afflicting these two segments of the population. Among more than 2,000 pneumococcal bacteremias occurring in adults in the United States in the past five years, over half were caused by pneumococcal References 1. MacLeod CM, Hodges RG, Heidelberger M, et al: Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides . J Exp Med 82:445-465, 1945.Crossref 2. Kaufman P: Pneumonia in old age . Arch Intern Med 79:518-531, 1947.Crossref 3. Heidelberger M, MacLeod CM, Di-Lapi M: The human antibody response to the simultaneous injection of six specific polysaccharides of pneumococcus . J Exp Med 88:369-372, 1948.Crossref 4. Heidelberger M: Persistence of anti bodies in man after immunization , in Pappenheimer AM Jr. (ed): The Nature and Significance of the Antibody Response . New York, Columbia University Press, 1953, pp 90-101. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

PNEUMOCOCCAL INFECTIONS IN SICKLE CELL ANEMIA

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1972.02110120138031
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.—This letter is prompted by the article of Seeler et al (Amer J Dis Child 123:8-10, 1972) and by the editorial of Lukens (123:6-7, 1972), both of which express a pessimistic outlook regarding the potential utility of pneumococcal vaccines for the prevention of pneumococcal infections in children with sickle cell anemia. A more optimistic view of prophylactic vaccination seems warranted, perhaps, although extrapolations based upon the small sample reported by Seeler et al must be guarded. Study of pneumococcal infection in large numbers of both children and adults demonstrates clearly that the preponderance of such infections is caused by a limited number of the 82 pneumococcal capsular types, although there are some clear-cut differences in the types afflicting these two segments of the population. Among more than 2,000 pneumococcal bacteremias occurring in adults in the United States in the past five years, over half were caused by pneumococcal References 1. MacLeod CM, Hodges RG, Heidelberger M, et al: Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides . J Exp Med 82:445-465, 1945.Crossref 2. Kaufman P: Pneumonia in old age . Arch Intern Med 79:518-531, 1947.Crossref 3. Heidelberger M, MacLeod CM, Di-Lapi M: The human antibody response to the simultaneous injection of six specific polysaccharides of pneumococcus . J Exp Med 88:369-372, 1948.Crossref 4. Heidelberger M: Persistence of anti bodies in man after immunization , in Pappenheimer AM Jr. (ed): The Nature and Significance of the Antibody Response . New York, Columbia University Press, 1953, pp 90-101.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1972

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