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Observations on Cystic Fibrosis of the Pancreas: The Apocrine Gland

Observations on Cystic Fibrosis of the Pancreas: The Apocrine Gland Abstract Dilatation of apocrine glands with retained secretions was found in nearly one third of autopsied patients with cystic fibrosis. The changes were most severe and frequent (eight of 13) in children over 7 years of age. Less marked alterations were found to be significantly less common in a control group of unaffected infants and children. Histochemical techniques were used to demonstrate the presence of neutral and acid mucopolysaccharides, including both sulfomucins and carboxymucins. No qualitative difference in staining reactions was detected between patients with cystic fibrosis and control cases. In spite of the similarity to other lesions in cystic fibrosis, the significance of the apocrine changes in these affected children is unknown because of their frequency in normal adults. References 1. Farber S: Pancreatic function and disease in early life: V. Pathologic changes associated with pancreatic insufficiency in early life . Arch Path 37:238-250, 1944. 2. Winkelmann RK, Hultin JR: Mucinous metaplasia in normal apocrine glands . Arch Derm 78:309-313, 1958.Crossref 3. Montagna W: Histology and cytochemistry of human skin: XIX. Development and fate of the axillary organ . J Invest Derm 33:151-161, 1959.Crossref 4. Hurley HH, Shelley WB: The Apocrine Sweat Gland in Health and Disease . Springfield, Ill, Charles C Thomas Publisher, 1960, pp 97-129. 5. Spicer SS: Diamine methods for differentiating mucosubstances histochemically . J Histochem Cytochem 13:211-234, 1965.Crossref 6. Pearse AGE: Histochemistry: Theoretical and Applied . Boston, Little Brown & Co, 1968, p 670. 7. Munger BL, Brusilow SW, Cooke RE: An electron microscopic study of eccrine sweat glands in patients with cystic fibrosis of the pancreas . J Pediat 59:497-511, 1961.Crossref 8. Bartman J, Landing BH: Morphology of the sweat apparatus in cystic fibrosis . Amer J Clin Path 45:455-459, 1966. 9. Lev R, Spicer SS: A histochemical comparison of human epithelial mucins in normal and hypersecretory states including pancreatic cystic fibrosis . Amer J Path 46:23-47, 1965. 10. Esterly JR, Spicer SS: Mucin histochemistry of human gall bladder: Changes in adenocarcinoma, cystic fibrosis, and cholecystitis . J Nat Cancer Inst 40:1-10, 1968. 11. Oppenheimer EH, Esterly JR: Observations on cystic fibrosis of the pancreas: VI. The uterine cervix . J Pediat 77:991-995, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Observations on Cystic Fibrosis of the Pancreas: The Apocrine Gland

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1972.02110090070005
Publisher site
See Article on Publisher Site

Abstract

Abstract Dilatation of apocrine glands with retained secretions was found in nearly one third of autopsied patients with cystic fibrosis. The changes were most severe and frequent (eight of 13) in children over 7 years of age. Less marked alterations were found to be significantly less common in a control group of unaffected infants and children. Histochemical techniques were used to demonstrate the presence of neutral and acid mucopolysaccharides, including both sulfomucins and carboxymucins. No qualitative difference in staining reactions was detected between patients with cystic fibrosis and control cases. In spite of the similarity to other lesions in cystic fibrosis, the significance of the apocrine changes in these affected children is unknown because of their frequency in normal adults. References 1. Farber S: Pancreatic function and disease in early life: V. Pathologic changes associated with pancreatic insufficiency in early life . Arch Path 37:238-250, 1944. 2. Winkelmann RK, Hultin JR: Mucinous metaplasia in normal apocrine glands . Arch Derm 78:309-313, 1958.Crossref 3. Montagna W: Histology and cytochemistry of human skin: XIX. Development and fate of the axillary organ . J Invest Derm 33:151-161, 1959.Crossref 4. Hurley HH, Shelley WB: The Apocrine Sweat Gland in Health and Disease . Springfield, Ill, Charles C Thomas Publisher, 1960, pp 97-129. 5. Spicer SS: Diamine methods for differentiating mucosubstances histochemically . J Histochem Cytochem 13:211-234, 1965.Crossref 6. Pearse AGE: Histochemistry: Theoretical and Applied . Boston, Little Brown & Co, 1968, p 670. 7. Munger BL, Brusilow SW, Cooke RE: An electron microscopic study of eccrine sweat glands in patients with cystic fibrosis of the pancreas . J Pediat 59:497-511, 1961.Crossref 8. Bartman J, Landing BH: Morphology of the sweat apparatus in cystic fibrosis . Amer J Clin Path 45:455-459, 1966. 9. Lev R, Spicer SS: A histochemical comparison of human epithelial mucins in normal and hypersecretory states including pancreatic cystic fibrosis . Amer J Path 46:23-47, 1965. 10. Esterly JR, Spicer SS: Mucin histochemistry of human gall bladder: Changes in adenocarcinoma, cystic fibrosis, and cholecystitis . J Nat Cancer Inst 40:1-10, 1968. 11. Oppenheimer EH, Esterly JR: Observations on cystic fibrosis of the pancreas: VI. The uterine cervix . J Pediat 77:991-995, 1970.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1972

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