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BENIGNITY OF NEONATAL TUMORS

BENIGNITY OF NEONATAL TUMORS Abstract To the Editor.—Bolande1 has drawn attention to the benign nature of neonatal tumors and discussed the concept of cancer repression in early life. There are two other tumors that could be added to his list. The yolk sac tumor of the testes has a much better prognosis in younger patients. More important, in over 700 cases of Burkitt's lymphoma reported from Africa, there were no patients under one year old. I have already suggested an alternative reason for these findings.2 The improved prognosis could be related to passive immunity inherited from the mother. Passive immunological defenses are maximal at birth and decay slowly thereafter until active immunologic defense mechanisms take over. There is some experimental evidence to support this theory. Mothers and close relatives of children with neuroblastoma are immune to neuroblastoma antigens. Moreover, it has been shown that at least the mothers have cytotoxic antibodies References 1. Bolande RP: Benignity of neonatal tumors and concept of cancer repression in early life . Amer J Dis Child 122:12-14, 1971. 2. Lowry WS: Passive immunotherapy for neuroblastoma . Lancet 2:1366, 1970.Crossref 3. Hellstrom I, Hellstrom KE, Bill AH: Studies on cellular immunity to human neuroblastoma cells . Int J Cancer 6:172-188, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

BENIGNITY OF NEONATAL TUMORS

LOWRY, W. S.
American Journal of Diseases of Children , Volume 123 (1) – Jan 1, 1972
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BENIGNITY OF NEONATAL TUMORS

Abstract

Abstract To the Editor.—Bolande1 has drawn attention to the benign nature of neonatal tumors and discussed the concept of cancer repression in early life. There are two other tumors that could be added to his list. The yolk sac tumor of the testes has a much better prognosis in younger patients. More important, in over 700 cases of Burkitt's lymphoma reported from Africa, there were no patients under one year old. I have already suggested an alternative reason for these findings.2...
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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1972.02110070135028
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.—Bolande1 has drawn attention to the benign nature of neonatal tumors and discussed the concept of cancer repression in early life. There are two other tumors that could be added to his list. The yolk sac tumor of the testes has a much better prognosis in younger patients. More important, in over 700 cases of Burkitt's lymphoma reported from Africa, there were no patients under one year old. I have already suggested an alternative reason for these findings.2 The improved prognosis could be related to passive immunity inherited from the mother. Passive immunological defenses are maximal at birth and decay slowly thereafter until active immunologic defense mechanisms take over. There is some experimental evidence to support this theory. Mothers and close relatives of children with neuroblastoma are immune to neuroblastoma antigens. Moreover, it has been shown that at least the mothers have cytotoxic antibodies References 1. Bolande RP: Benignity of neonatal tumors and concept of cancer repression in early life . Amer J Dis Child 122:12-14, 1971. 2. Lowry WS: Passive immunotherapy for neuroblastoma . Lancet 2:1366, 1970.Crossref 3. Hellstrom I, Hellstrom KE, Bill AH: Studies on cellular immunity to human neuroblastoma cells . Int J Cancer 6:172-188, 1970.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jan 1, 1972

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