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Echovirus 14 Infection Associated With Fatal Neonatal Hepatic Necrosis

Echovirus 14 Infection Associated With Fatal Neonatal Hepatic Necrosis Abstract Echovirus 14 was isolated from the liver of a newborn infant with fatal hepatic necrosis. It appeared likely that the infection was acquired in utero. Ultrastructurally, the findings in the liver cells were consistent with a viral infection. In cell cultures the viral isolate was found to produce crystalline inclusions in the nucleus and cytoplasm. Negative stained virions measured approximately 30.3 mμ in diameter. To our knowledge, the electron microscopy of echovirus 14 has not been previously reported. References 1. Ryter A, Kellenberger E: L'inclusion au polyester pour l'ultramicrotomie . J Ultrastruct Res 2:200-214, 1958.Crossref 2. Hoyos-Guevara E de: Vestopal W embedding of cell culture monolayers for electron microscopy . Patologia 9:143-149, 1971. 3. Ruebner BH, Bhagaran BS, Greenfield AJ, et al: Neonatal hepatic necrosos . Pediatrics 43:963-970, 1969. 4. Godman GC, Rifkind RA, Howe C, et al: A description of echo-9 virus infection in cultured cells: I. The cytopathic effect . Amer J Path 44:1-27, 1964. 5. Margolis G, Kilham L, Ruffolo PR: Rat virus disease, an experimental model of neonatal hepatitis . Exp Molec Path 8:1-20, 1968.Crossref 6. Goodman GC, Rifkind RA, Page RB, et al: A description of echo-9 virus infection in cultured cells: II. Cytochemical observations . Amer J Path 44:215-245, 1964. 7. Svoboda D, Higginson J: A comparison of ultrastructural changes in the rat liver due to chemcial carcinogens . Cancer Res 28:1703-1733, 1968. 8. Enders JF, McCarthy K, Mitus A, et al: Isolation of measles virus at autopsy in association of giant cell pneumonia without rash . New Eng J Med 261:875-881, 1959.Crossref 9. Rabin ER, Jenson AB: Electron microscopic studies of animal viruses with emphasis on in vivo infections . Progr Med Virol 9:392-450, 1967. 10. Jézéquel A-M, Steiner JW: Some ultrastructural and histochemical aspects of coxsackievirus-cell interactions . Lab Invest 15:1055-1083, 1966. 11. Kibrick S. Benirschke K: Severe generalized disease (encephalohepatomyocarditis) occurring in the newborn period and due to infection with coxsackievirus, group B: Evidence of intrauterine infection with this agent . Pediatrics 22:857-875, 1958. 12. Nogen AG, Lepow ML: Enteroviral meningitis in very young infants . Pediatrics 40:617-626, 1967. 13. Berkovich S, Pangan J: Recovery of virus from premature infants during outbreaks of respiratory disease: The relation of echovirus type 22 to disease of upper- and lower- respiratory tract in the premature infant . Bull NY Acad Med 44:377-387, 1968. 14. Sanders DY, Cramblett HG: Viral infections in hospitalized neonates . Amer J Dis Child 116:251-258, 1968. 15. Hersey DF, Shaw ED: Viral agents in hepatitis: A review . Lab Invest 19:558-572, 1968. 16. Drouhet V: Infections à virus entériques chez les enfants et syndromes cliniques associés . Ann Inst Pasteur 98:562-568, 1960. 17. Melnick JL: Echo viruses: Symposium on cellular biology, nucleic acids and viruses . NY Acad Sci (special publications) 5:367-381, 1957. 18. Ormsbee RA, Bell EJ: Echoviruses from Idaho and Montana . Amer J Puclic Health 47:1405-1413, 1957.Crossref 19. Ramos-Alvarez M, Sabin AB: Enteropathogenic viruses and bacteria: Role in summer diarrheal diseases of infancy and early childhood . JAMA 167:147-156, 1958.Crossref 20. Lépine P, Samaille J, Maurin J, et al: Isolement du virus echo 14 au cours d'une épidémie de crèche de gastroentérites . Ann Inst Pasteur 99:161-166, 1960. 21. Lepow ML, Carver DH, Wright HT Jr, et al: A clinical, epidemiologic and laboratory investigation of aseptic meningitis during the four-year period, 1955-1958: I. Observations concerning etiology and epidemiology . New Eng J Med 266:1181-1187, 1962.Crossref 22. Kelen AE, Delbin D, Lesiak JM, et al: Isolation of enteric viruses in Ontario, during 1960-1962 . Canad Med Assoc J 89:921-926, 1963. 23. Hinuma Y, Marai Y: Two outbreaks of echovirus 14 infection: A possible interference with oral poliovirus vaccine and a probable association with aseptic meningitis . J Hyg 63:277-284, 1965.Crossref 24. Monaldi T de S, Benedetto A, Formato GF: Epidémie de maladie entérique aiguë associée à l'infection à virus echo 14 . Helv Paediat Acta 3:239-249, 1966. 25. Bell EJ, Grist NR: Echoviruses, carditis and acute pleurodynia . Lancet 1:326-328, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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References (26)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1972.02110070111017
Publisher site
See Article on Publisher Site

Abstract

Abstract Echovirus 14 was isolated from the liver of a newborn infant with fatal hepatic necrosis. It appeared likely that the infection was acquired in utero. Ultrastructurally, the findings in the liver cells were consistent with a viral infection. In cell cultures the viral isolate was found to produce crystalline inclusions in the nucleus and cytoplasm. Negative stained virions measured approximately 30.3 mμ in diameter. To our knowledge, the electron microscopy of echovirus 14 has not been previously reported. References 1. Ryter A, Kellenberger E: L'inclusion au polyester pour l'ultramicrotomie . J Ultrastruct Res 2:200-214, 1958.Crossref 2. Hoyos-Guevara E de: Vestopal W embedding of cell culture monolayers for electron microscopy . Patologia 9:143-149, 1971. 3. Ruebner BH, Bhagaran BS, Greenfield AJ, et al: Neonatal hepatic necrosos . Pediatrics 43:963-970, 1969. 4. Godman GC, Rifkind RA, Howe C, et al: A description of echo-9 virus infection in cultured cells: I. The cytopathic effect . Amer J Path 44:1-27, 1964. 5. Margolis G, Kilham L, Ruffolo PR: Rat virus disease, an experimental model of neonatal hepatitis . Exp Molec Path 8:1-20, 1968.Crossref 6. Goodman GC, Rifkind RA, Page RB, et al: A description of echo-9 virus infection in cultured cells: II. Cytochemical observations . Amer J Path 44:215-245, 1964. 7. Svoboda D, Higginson J: A comparison of ultrastructural changes in the rat liver due to chemcial carcinogens . Cancer Res 28:1703-1733, 1968. 8. Enders JF, McCarthy K, Mitus A, et al: Isolation of measles virus at autopsy in association of giant cell pneumonia without rash . New Eng J Med 261:875-881, 1959.Crossref 9. Rabin ER, Jenson AB: Electron microscopic studies of animal viruses with emphasis on in vivo infections . Progr Med Virol 9:392-450, 1967. 10. Jézéquel A-M, Steiner JW: Some ultrastructural and histochemical aspects of coxsackievirus-cell interactions . Lab Invest 15:1055-1083, 1966. 11. Kibrick S. Benirschke K: Severe generalized disease (encephalohepatomyocarditis) occurring in the newborn period and due to infection with coxsackievirus, group B: Evidence of intrauterine infection with this agent . Pediatrics 22:857-875, 1958. 12. Nogen AG, Lepow ML: Enteroviral meningitis in very young infants . Pediatrics 40:617-626, 1967. 13. Berkovich S, Pangan J: Recovery of virus from premature infants during outbreaks of respiratory disease: The relation of echovirus type 22 to disease of upper- and lower- respiratory tract in the premature infant . Bull NY Acad Med 44:377-387, 1968. 14. Sanders DY, Cramblett HG: Viral infections in hospitalized neonates . Amer J Dis Child 116:251-258, 1968. 15. Hersey DF, Shaw ED: Viral agents in hepatitis: A review . Lab Invest 19:558-572, 1968. 16. Drouhet V: Infections à virus entériques chez les enfants et syndromes cliniques associés . Ann Inst Pasteur 98:562-568, 1960. 17. Melnick JL: Echo viruses: Symposium on cellular biology, nucleic acids and viruses . NY Acad Sci (special publications) 5:367-381, 1957. 18. Ormsbee RA, Bell EJ: Echoviruses from Idaho and Montana . Amer J Puclic Health 47:1405-1413, 1957.Crossref 19. Ramos-Alvarez M, Sabin AB: Enteropathogenic viruses and bacteria: Role in summer diarrheal diseases of infancy and early childhood . JAMA 167:147-156, 1958.Crossref 20. Lépine P, Samaille J, Maurin J, et al: Isolement du virus echo 14 au cours d'une épidémie de crèche de gastroentérites . Ann Inst Pasteur 99:161-166, 1960. 21. Lepow ML, Carver DH, Wright HT Jr, et al: A clinical, epidemiologic and laboratory investigation of aseptic meningitis during the four-year period, 1955-1958: I. Observations concerning etiology and epidemiology . New Eng J Med 266:1181-1187, 1962.Crossref 22. Kelen AE, Delbin D, Lesiak JM, et al: Isolation of enteric viruses in Ontario, during 1960-1962 . Canad Med Assoc J 89:921-926, 1963. 23. Hinuma Y, Marai Y: Two outbreaks of echovirus 14 infection: A possible interference with oral poliovirus vaccine and a probable association with aseptic meningitis . J Hyg 63:277-284, 1965.Crossref 24. Monaldi T de S, Benedetto A, Formato GF: Epidémie de maladie entérique aiguë associée à l'infection à virus echo 14 . Helv Paediat Acta 3:239-249, 1966. 25. Bell EJ, Grist NR: Echoviruses, carditis and acute pleurodynia . Lancet 1:326-328, 1970.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1972

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