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Adult Women Vaccinated With Rubella Vaccine: A Preliminary Report on Controlled Studies With Cendehill Strain

Adult Women Vaccinated With Rubella Vaccine: A Preliminary Report on Controlled Studies With... Abstract IN JUNE 1968, Cooper and Krugman1 observed transient arthritis in women receiving the dog kidney-adapted derivative of HPV-77. Subsequently, Stokes et al2 reported 15 cases of arthralgia and arthritis reactions in 35 susceptible adult women vaccinated with HPV-77 rubella vaccine passed five times in duck embryo (DE) cell culture. These reactions were rated as mild to severe and included one case in which rubella virus was isolated from an affected knee joint. Extending these observations, Cooper et al3 reported 14 cases of arthralgia and arthritis manifestations, ranging from mild to severe, in 25 seronegative adult women vaccinated with HPV-77 DK12 rubella vaccine, and four mild arthralgic reactions in 13 adult women vaccinated with Cendehill rubella vaccine. In a comparative study by Horstmann et al,4 utilizing HPV-77 DE5 plus γ-globulin and Cendehill vaccine alone in seronegative adult women, arthritic manifestations were noted in four of 12 References 1. Cooper, L.Z., and Krugman, S.: Report to the Division of Biologics Standards and the Vaccine Development Board, National Institutes of Health, Bethesda, Md, May 1968. 2. Stokes, J., et al: "Vaccination of Adult Females With HPV-77 Rubella Vaccine," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, November 1968, Basel, Switzerland: S. Karger, 1969, pp 415-422. 3. Cooper, L.Z., et al: "Arthritis Following Immunization With Rubella Vaccines," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969, pp 435-442. 4. Horstmann, D.M., et al: "Comparison of HPV 77-D5 and Cendehill Strain Vaccines in Adult Women," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969, pp 429-434. 5. Marshall, W.C.; Dudgeon, J.A.; and Peckham, C.F.: "Clinical Studies of Rubella Vaccines in Adults," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969, pp 423-428. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Adult Women Vaccinated With Rubella Vaccine: A Preliminary Report on Controlled Studies With Cendehill Strain

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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040266022
Publisher site
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Abstract

Abstract IN JUNE 1968, Cooper and Krugman1 observed transient arthritis in women receiving the dog kidney-adapted derivative of HPV-77. Subsequently, Stokes et al2 reported 15 cases of arthralgia and arthritis reactions in 35 susceptible adult women vaccinated with HPV-77 rubella vaccine passed five times in duck embryo (DE) cell culture. These reactions were rated as mild to severe and included one case in which rubella virus was isolated from an affected knee joint. Extending these observations, Cooper et al3 reported 14 cases of arthralgia and arthritis manifestations, ranging from mild to severe, in 25 seronegative adult women vaccinated with HPV-77 DK12 rubella vaccine, and four mild arthralgic reactions in 13 adult women vaccinated with Cendehill rubella vaccine. In a comparative study by Horstmann et al,4 utilizing HPV-77 DE5 plus γ-globulin and Cendehill vaccine alone in seronegative adult women, arthritic manifestations were noted in four of 12 References 1. Cooper, L.Z., and Krugman, S.: Report to the Division of Biologics Standards and the Vaccine Development Board, National Institutes of Health, Bethesda, Md, May 1968. 2. Stokes, J., et al: "Vaccination of Adult Females With HPV-77 Rubella Vaccine," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, November 1968, Basel, Switzerland: S. Karger, 1969, pp 415-422. 3. Cooper, L.Z., et al: "Arthritis Following Immunization With Rubella Vaccines," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969, pp 435-442. 4. Horstmann, D.M., et al: "Comparison of HPV 77-D5 and Cendehill Strain Vaccines in Adult Women," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969, pp 429-434. 5. Marshall, W.C.; Dudgeon, J.A.; and Peckham, C.F.: "Clinical Studies of Rubella Vaccines in Adults," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969, pp 423-428.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Aug 1, 1969

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